Chikungunya and Zika virus cases detected against a backdrop of endemic dengue transmission in Vietnam by Quyen, N, Kien, D, Rabaa, M, Tuan, N, Vi, T, Van Tan, L, Hung, N, Tuan, H, Van Tram, T, Le Da Ha, N, Quang, H, Doanh, N, Van Vinh Chau, N, Wills, B, Simmons, C

“…Against a backdrop of endemic dengue transmission, chikungunya and Zika present an additional arboviral disease burden in Vietnam.…”

Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission. by Raghwani, J, Rambaut, A, Holmes, E, Hang, V, Hien, T, Farrar, J, Wills, B, Lennon, N, Birren, B, Henn, MR, Simmons, C

“…Despite this widespread dispersal, the determinants of dengue transmission in endemic populations are not well understood, although essential for virus control. …”

Dengue virus in sub-tropical northern and central Viet Nam: population immunity and climate shape patterns of viral invasion and maintenance by Rabaa, M, Simmons, C, Fox, A, Le, M, Nguyen, T, Le, H, Gibbons, R, Nguyen, X, Holmes, E, Aaskov, J

“…Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world. …”

Dengue human infection models supporting drug development by Whitehorn, J, Van, V, Simmons, C

“…A DHIM could allow experimentally controlled studies of candidate therapeutics in preselected susceptible volunteers, potentially using smaller sample sizes than trials that recruited patients with dengue in an endemic country. In addition, the DHIM would assist the conduct of intensive pharmacokinetic and basic research investigations and aid in determining optimal drug dosage. …”

Comparative susceptibility of Aedes albopictus and Aedes aegypti to dengue virus infection after feeding on blood of viremic humans: Implications for public health by Whitehorn, J, Kien, D, Nguyen, N, Nguyen, H, Kyrylos, P, Carrington, L, Tran, C, Quyen, N, Thi, L, Le Thi, D, Truong, N, Luong, T, Nguyen, C, Wills, B, Wolbers, M, Simmons, C

“…Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. …”

Clinical and virological features of Dengue in Vietnamese infants. by Chau, T, Anders, K, Lien, L, Hung, N, Hieu, LT, Tuan, N, Thuy, T, Phuong, LT, Tham, N, Lanh, M, Farrar, J, Whitehead, S, Simmons, C

“… BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. …”

Within-host viral dynamics of dengue serotype 1 infection by Clapham, H, Tricou, V, Van Vinh Chau, N, Simmons, C, Ferguson, N

“…Dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical Asia and is increasing in its geographical range. …”

Synchrony of Dengue Incidence in Ho Chi Minh City and Bangkok. by Hoang Quoc, C, Henrik, S, Isabel, R, In-Kyu, Y, Chau, N, Hung, N, Tuan, H, Lan, P, Willis, B, Nisalak, A, Kalayanarooj, S, Cummings, D, Simmons, C

“…BACKGROUND: Ho Chi Minh City and Bangkok are highly dengue endemic. The extent to which disease patterns are attributable to local versus regional dynamics remains unclear. …”

Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. by Vu, T, Holmes, E, Duong, V, Nguyen, T, Tran, T, Quail, M, Churcher, C, Parkhill, J, Cardosa, J, Farrar, J, Wills, B, Lennon, N, Birren, B, Buchy, P, Henn, MR, Simmons, C

“…A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. …”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, M, Deubel, V, Frutos, R, Buchy, P

“… <p style="text-align:justify;"> In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. …”

Dengue in Vietnamese infants--results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity... by Chau, T, Quyen, N, Thuy, T, Tuan, N, Hoang, D, Dung, N, Lien, L, Quy, N, Hieu, N, Hieu, LT, Hien, T, Hung, N, Farrar, J, Simmons, C

“…These results also highlight potential risks in the use of live attenuated dengue vaccines in infants in countries where dengue is endemic.…”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, MR, Deubel, V, Frutos, R, Buchy, P

“…In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. …”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, MR, Deubel, V, Frutos, R, Buchy, P

“…In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. …”

Emergence of the Asian 1 genotype of dengue Virus serotype 2 in viet Nam: in vivo fitness advantage and lineage replacement in South-East Asia by Hang, V, Holmes, E, Veasna, D, Quy, N, Hien, T, Quail, M, Churcher, C, Parkhill, J, Cardosa, J, Farrar, J, Wills, B, Lennon, N, Birren, B, Buchy, P, Henn, MR, Simmons, C

“…A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. …”

Assessing dengue vaccination impact: Model challenges and future directions. by Recker, M, Vannice, K, Hombach, J, Jit, M, Simmons, C

“…The WHO has provided guidance on the use of CYDTDV in endemic countries, for which there are a variety of considerations beyond the risk–benefit evaluation done by regulatory authorities, including public health impact and cost-effectiveness. …”

Clinical features of dengue in a large Vietnamese cohort: intrinsically lower platelet counts and greater risk for bleeding in adults than children. by Trung, D, Thao, T, Dung, N, Ngoc, T, Hien, T, Chau, N, Wolbers, M, Tam, D, Farrar, J, Simmons, C, Wills, B

“…As dengue spreads to new geographical regions and the force of infection changes in existing endemic areas, a greater breadth of clinical presentations is being recognised. …”

A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome by Lam, P, Tam, D, Dung, N, Tien, N, Kieu, N, Simmons, C, Farrar, J, Wills, B, Wolbers, M

“…The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.…”

Phylogeography of recently emerged DENV-2 in southern Viet Nam by Rabaa, M, Ty Hang, V, Wills, B, Farrar, J, Simmons, C, Holmes, E

“…Herein, we investigated trends in the spatial dynamics of DENV-2 transmission in the highly endemic setting of southern Viet Nam. Through a phylogeographic analysis of 168 full-length DENV-2 genome sequences obtained from hospitalized dengue cases from 10 provinces in southern Viet Nam, we reveal substantial genetic diversity in both urban and rural areas, with multiple lineages identified in individual provinces within a single season, and indicative of frequent viral migration among communities. …”

An evidence-based algorithm for early prognosis of severe dengue in the outpatient setting. by Nguyen, M, Ho, T, Nguyen, V, Nguyen, T, Ha, M, Ta, V, Nguyen, L, Phan, L, Han, K, Duong, T, Tran, N, Wills, B, Wolbers, M, Simmons, C

“…A score-chart, for routine clinical use, was derived from the prognostic model and could improve triage and management of children presenting with fever in dengue endemic areas.…”

Clinical features of dengue in a large Vietnamese cohort: intrinsically lower platelet counts and greater risk for bleeding in adults than children. by Trung, D, Thao, L, Dung, N, Ngoc, T, Hien, T, Chau, N, Wolbers, M, Tam, D, Farrar, J, Simmons, C, Wills, B

“… BACKGROUND: As dengue spreads to new geographical regions and the force of infection changes in existing endemic areas, a greater breadth of clinical presentations is being recognised. …”