Brain responses in infants by Hartley, C, Slater, R

“…We cannot know whether another person is experiencing pain unless they tell us, making reliable pain assessment difficult in nonverbal infants. Consequently, the treatment of infant pain is reliant on inferences based on observations. …”

Measuring pain in the newborn infant by Green, G

“…<p>Hospitalised infants require multiple painful procedures a day as part of their essential medical care. …”

Improving the treatment of infant pain by Moultrie, F, Slater, R, Hartley, C

“…Here we review recent advances in the measurement of infant pain and discuss clinical trials that assess the efficacy of pharmacological analgesia in infants. …”

Improving the measurement and treatment of infant pain by Gursul, D

Subjects:

Multi-modal pain measurements in infants by Worley, A, Fabrizi, L, Boyd, S, Slater, R

Electrophysiological Measurements and Analysis of Nociception in Human Infants by Fabrizi, L, Worley, A, Patten, D, Holdridge, S, Cornelissen, L, Meek, J, Boyd, S, Slater, R

Premature infants display increased noxious-evoked neuronal activity in the brain compared to healthy age-matched term-born infants. by Slater, R, Fabrizi, L, Worley, A, Meek, J, Boyd, S, Fitzgerald, M

“…We have measured evoked potentials generated by noxious clinically-essential heel lances in infants born at term (8 infants; born 37-40weeks) and in infants born prematurely (7 infants; born 24-32weeks) who had reached the same postmenstrual age (mean age at time of heel lance 39.2+/-1.2weeks). …”

Predicting severity of adverse cardiorespiratory effects of morphine in premature infants: a post hoc analysis of Procedural Pain in Premature Infants trial data by Hartley, C, Baxter, L, Moultrie, F, Purdy, R, Bhatt, A, Rogers, R, Patel, C, Adams, E, Slater, R

Investigating pain in the developing human brain by Moultrie, FA

Subjects:

Birth experience in newborn infants is associated with changes in nociceptive sensitivity by Kasser, S, Hartley, C, Rickenbacher, H, Klarer, N, Depoorter, A, Datta, A, Cobo, M, Goksan, S, Hoskin, A, Magerl, W, Huhn, E, Green, G, Slater, R, Wellmann, S

“…It confers respiratory, cardiovascular and homeostatic advantages to the newborn infant compared with elective cesarean section, and is reported to provide neonatal analgesia. …”

Nociceptive brain activity as a measure of analgesic efficacy in infants by Hartley, C, Duff, E, Green, G, Schmidt Mellado, G, Worley, A, Rogers, R, Slater, R

“…Pain in infants is under-treated and poorly understood, representing a significant clinical problem. …”

Sugaring the Pill Ethics and Uncertainties in the Use of Sucrose for Newborn Infants by Wilkinson, D, Savulescu, J, Slater, R

“…Sucrose is widely used for the management of procedural pain in newborn infants, including capillary blood sampling, venepuncture, and vascular cannulation. …”

Stroking modulates noxious-evoked brain activity in human infants by Gursul, D, Goksan, S, Hartley, C, Shmidt Mellado, G, Moultrie, F, Hoskin, A, Adams, E, Hathway, G, Walker, S, McGlone, F, Slater, R

Sugaring the pill: ethics and uncertainties in the use of sucrose for newborn infants. by Wilkinson, D, Savulescu, J, Slater, R

“…Sucrose is widely used for the management of procedural pain in newborn infants, including capillary blood sampling, venepuncture, and vascular cannulation. …”

Multimodal characterisation of the infant response to retinopathy of prematurity screening and treatment by Buckle, M

“…<p>Retinopathy of prematurity (ROP) is a condition which affects premature infants and is a cause of childhood blindness. Screening is performed repeatedly during the preterm period, using binocular indirect ophthalmoscopy (BIO), to identify disease at a treatable stage; unfortunately screening and treatment are considered to be painful and stressful for infants. …”

Behavioural discrimination of noxious stimuli in infants is dependent on brain maturation by Green, G, Hartley, C, Hoskin, A, Duff, E, Shriver, A, Wilkinson, D, Adams, E, Rogers, R, Moultrie, F, Slater, R

“…Changes in facial expression are an essential form of social communication and in nonverbal infants are often used to alert care providers to pain-related distress. …”

Evoked potentials generated by noxious stimulation in the human infant brain by Slater, R, Worley, A, Fabrizi, L, Roberts, S, Meek, J, Boyd, S, Fitzgerald, M

Using only behaviours to assess infant pain: a painful compromise? by Pillai Riddell, R, Fitzgerald, M, Slater, R, Stevens, B, Johnston, C, Campbell-Yeo, M

Sensory event-related potential morphology predicts age in premature infants by Zandvoort, CS, van der Vaart, M, Robinson, S, Usman, F, Schmidt Mellado, G, Evans Fry, R, Worley, A, Adams, E, Slater, R, Baxter, L, de Vos, M, Hartley, C

“…<p><strong>Objective:</strong>&nbsp;We investigated whether sensory-evoked cortical potentials could be used to estimate the age of an infant. Such a model could be used to identify infants who deviate from normal neurodevelopment.…”

New method to measure interbreath intervals in infants for the assessment of apnoea and respiration by Adjei, T, Purdy, R, Jorge, J, Adams, E, Buckle, M, Evans Fry, R, Green, G, Patel, C, Rogers, R, Slater, R, Tarassenko, L, Villarroel, M, Hartley, C

“…<strong>Background</strong> Respiratory disorders, including apnoea, are common in preterm infants due to their immature respiratory control compared with term-born infants. …”