Oxidative Stress and Neurodegeneration in Animal Models of Seizures and Epilepsy by Krzysztof Łukawski, Stanisław J. Czuczwar

“…The present review is devoted to the generation of free radicals in some animal models of seizures and epilepsy and the consequences of oxidative stress, such as DNA or mitochondrial damage leading to neurodegeneration. Additionally, antioxidant properties of antiepileptic (antiseizure) drugs and a possible use of antioxidant drugs or compounds in patients with epilepsy are reviewed. …”
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Neuroinflammation in Post-Ischemic Neurodegeneration of the Brain: Friend, Foe, or Both? by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

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Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

“…Thus, the knowledge of new neurodegenerative mechanisms that cause neurodegeneration of the hippocampus after ischemia, resembling Alzheimer’s disease proteinopathy, will provide the most important therapeutic development goals to date.…”
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Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia by Marzena Ułamek-Kozioł, Stanisław J. Czuczwar, Sławomir Januszewski, Ryszard Pluta

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Myricetin as a Promising Molecule for the Treatment of Post-Ischemic Brain Neurodegeneration by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

“…The available drug therapy for post-ischemic neurodegeneration of the brain is symptomatic. This review provides an evaluation of possible dietary therapy for post-ischemic neurodegeneration with myricetin. …”
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Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia by Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J. Czuczwar

“…We present the latest data that Alzheimer’s disease-related proteins and their genes play a crucial role in postischemic neurodegeneration. Understanding the underlying processes of linking Alzheimer’s disease-related proteins and their genes in development of postischemic neurodegeneration will provide the most significant goals to date for therapeutic development.…”
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The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type by Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski, Mirosław Jabłoński

“…Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology. …”
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Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Possible Therapeutic Role of Curcumin by Ryszard Pluta, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Stanisław J. Czuczwar

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Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease by Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J. Czuczwar

“…In this review, we summarize protein alterations associated with Alzheimer's disease and their gene expression (<i>amyloid protein precursor</i> and <i>tau protein</i>) after cerebral ischemia, as well as their roles in post-ischemic hippocampus neurodegeneration. In recent years, multiple studies aimed to elucidate the post-ischemic processes in the development of hippocampus neurodegeneration. …”
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Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids by Ryszard Pluta, Barbara Miziak, Stanisław J. Czuczwar

“…Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. …”
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Ischemia-Reperfusion Programming of Alzheimer’s Disease-Related Genes—A New Perspective on Brain Neurodegeneration after Cardiac Arrest by Ryszard Pluta, Stanisław J. Czuczwar

“…Finally, the results clearly indicate that changes in the expression of the presented genes play an important role in acute and secondary brain damage and the development of post-ischemic brain neurodegeneration with the Alzheimer’s disease phenotype. …”
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Post-Ischemic Permeability of the Blood–Brain Barrier to Amyloid and Platelets as a Factor in the Maturation of Alzheimer’s Disease-Type Brain Neurodegeneration by Ryszard Pluta, Barbara Miziak, Stanisław J. Czuczwar

“…The aim of this review is to present evidence of the impact of ischemic changes in the blood–brain barrier on the maturation of post-ischemic brain neurodegeneration with features of Alzheimer’s disease. …”
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Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy by Ryszard Pluta, Jacek Kiś, Sławomir Januszewski, Mirosław Jabłoński, Stanisław J. Czuczwar

“…Finally, we hypothesize that modified amyloid and the tau protein, along with the oxidative stress generated, are new key elements in the vicious circle important in the development of post-ischemic neurodegeneration in a type of Alzheimer’s disease proteinopathy.…”
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Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality? by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

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Second Generation of Antiepileptic Drugs and Oxidative Stress by Kamil Kośmider, Maciej Kamieniak, Stanisław J. Czuczwar, Barbara Miziak

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<i>Trans</i>- and <i>Cis</i>-Phosphorylated Tau Protein: New Pieces of the Puzzle in the Development of Neurofibrillary Tangles in Post-Ischemic Brain Neurodegeneration of the Alzheimer’s Disease-like Type by Ryszard Pluta, Stanisław J. Czuczwar

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Anti-Epileptogenic Effects of Antiepileptic Drugs by Barbara Miziak, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, Stanisław J. Czuczwar

“…Two questions thus arise: (1) Are AEDs able to inhibit SE-induced neurodegeneration? and (2) if so, can a probable neuroprotective potential of particular AEDs stop epileptogenesis? …”
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Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease by Barbara Miziak, Barbara Błaszczyk, Stanisław J. Czuczwar

“…Considering a close relationship between brain ischemia and AD, they may also reduce post-brain ischemia neurodegeneration. An investigational compound, CN-105 (a lipoprotein E agonist), has a very good profile in AD preclinical studies, and its clinical trial for postoperative dementia is starting soon.…”
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<i>LRP1</i> and <i>RAGE</i> Genes Transporting Amyloid and Tau Protein in the Hippocampal CA3 Area in an Ischemic Model of Alzheimer’s Disease with 2-Year Survival by Ryszard Pluta, Janusz Kocki, Jacek Bogucki, Anna Bogucka-Kocka, Stanisław J. Czuczwar

“…Explaining changes at the gene level that occur during neurodegeneration in the CA3 area is crucial from the point of view of memory impairment and the development of post-ischemic dementia. …”
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