MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain. by Mohseni, H, Smith, P, Parsons, C, Young, K, Hyam, J, Stein, J, Stein, A, Green, A, Aziz, T, Kringelbach, M

“…Using this beamforming method, we examined changes in whole-brain activity comparing pain relief achieved with deep brain stimulation (DBS ON) and compared with pain experienced with no stimulation (DBS OFF). …”

Thalamic field potentials in chronic central pain treated by periventricular gray stimulation -- a series of eight cases. by Nandi, D, Aziz, T, Carter, H, Stein, J

“…In addition, local field potentials (FPs) were recorded from the sensory thalamus during PVG stimulation. Maximum pain relief was obtained with 5-35 Hz stimulation while 50-100 Hz made the pain worse. …”

Phantom limb pain relieved with different modalities of central nervous system stimulation: a clinical and functional imaging case report of two patients. by Nandi, D, Yianni, J, Humphreys, J, Wang, S, O'sullivan, V, Shepstone, B, Stein, J, Aziz, T

“…We describe two cases of PLP that have been satisfactorily treated with CNS stimulation (motor cortex and then periventricular gray in one and spinal cord in the other) and have been subjected to single photon emission computed tomography (SPECT) studies when in pain and then during stimulation with recorded pain relief. We found that regardless of the site of stimulation in the CNS, pain relief is associated with blood flow changes in similar areas of the brain, mainly the parietal and cingulate cortex and also in the thalamic nuclei and the central gray matter. …”

Thalamic field potentials during deep brain stimulation of periventricular gray in chronic pain. by Nandi, D, Liu, X, Joint, C, Stein, J, Aziz, T

“…In addition, local field potentials (FPs) were recorded from the sensory thalamus during PVG stimulation. Maximum pain relief was obtained with 5-25 Hz stimulation while 50-100 Hz made the pain worse. …”

Deep brain stimulation: a new treatment for hypertension? by Green, A, Wang, S, Bittar, R, Owen, S, Paterson, D, Stein, J, Bain, P, Shlugman, D, Aziz, T

“…We report a 61-year-old hypertensive man who underwent deep brain stimulation of the periventricular/periaqueductal grey area for the relief of chronic neuropathic pain affecting his oral cavity and soft palate. …”

Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain. by Owen, S, Heath, J, Kringelbach, M, Green, A, Pereira, E, Jenkinson, E, Jegan, T, Stein, J, Aziz, T

“…A pre-operative DTI was obtained for each patient, who was then implanted with deep brain stimulation electrodes in the periventricular/periaqueductal grey area with good pain relief. Using seeds from the postoperative MRI scan, probabilistic tractography was performed from the pre-operative DTI.…”

Deep brain stimulation for chronic pain investigated with magnetoencephalography. by Kringelbach, M, Jenkinson, N, Green, A, Owen, S, Hansen, P, Cornelissen, P, Holliday, I, Stein, J, Aziz, T

“…Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.…”

Preoperative DTI and probabilistic tractography in an amputee with deep brain stimulation for lower limb stump pain. by Owen, S, Heath, J, Kringelbach, M, Stein, J, Aziz, T

“…A preoperative DTI was obtained from the patient, who then received DBS surgery in the PAG/PVG area with good pain relief. The postoperative MRI scan showing electrode placement was used to calculate four seed areas to represent the contacts on the Medtronic 3387 electrode. …”

Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. by Mohseni, H, Kringelbach, M, Probert Smith, P, Green, A, Parsons, C, Young, K, Brittain, J, Hyam, J, Schweder, P, Stein, J, Aziz, T

“…We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief.…”

Application of a Null-Beamformer to Source Localisation in MEG Data of Deep Brain Stimulation by Mohseni, H, Kringelbach, M, Smith, P, Green, A, Parsons, C, Young, K, Brittain, J, Hyam, J, Schweder, P, Stein, J, Aziz, T, IEEE

“…We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief. © 2010 IEEE.…”

Regional cerebral perfusion differences between periventricular grey, thalamic and dual target deep brain stimulation for chronic neuropathic pain. by Pereira, E, Green, A, Bradley, K, Soper, N, Moir, L, Stein, J, Aziz, T

“…Three patients with intractable neuropathic pain were assessed; one had stimulating electrodes in the ventroposterolateral thalamic nucleus (VPL), one in the periventricular grey (PVG) area, and one had electrodes in both targets. Pain relief was achieved in all patients. Cerebral perfusion was measured by single-photon emission computed tomography to determine the effects of DBS. …”

Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. by Mohseni, H, Kringelbach, M, Probert Smith, P, Green, A, Parsons, C, Young, K, Brittain, J, Hyam, J, Schweder, P, Stein, J, Aziz, T

“…We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief.…”

Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases. by Carroll, D, Joint, C, Maartens, N, Shlugman, D, Stein, J, Aziz, T

“…Ten patients suffering from phantom limb pain (n=3), post stroke pain (n=5), post traumatic neuralgia secondary to gunshot injury to the brain stem (n=1) and brachyalgia secondary to neuro-fibromatosis (n=150% pain relief) and long-term benefit in 4/5 of patients who initially responded to intermittent cortical stimulation (longest follow up 31 months after implantation). …”