Interaction analyses of 14-3-3ζ, Dok1, and phosphorylated integrin β cytoplasmic tails reveal a bi-molecular switch in integrin regulation by Chatterjee, Deepak, D'Souza, Areetha, Zhang, Yaming, Bin, Wu, Tan, Suet-Mien, Bhattacharjya, Surajit

Subjects: Get full text

Molecular condensation and mechanoregulation of plant class I formin, an integrin-like actin nucleator by Ma, Zhiming, Zhu, Kexin, Gao, Yong-Gui, Tan, Suet-Mien, Miao, Yansong

“…Plant class I formins are structurally integrated within the plant cell wall-plasma membrane-actin cytoskeleton (CW-PM-AC) continuum, sharing similar biophysical properties to mammalian integrins that are embedded within the extracellular matrix-PM-AC continuum. …”
Get full text

An alternative phosphorylation switch in integrin β2 (CD18) tail for Dok1 binding by Gupta, Sebanti, Chit, Joel Chia-Yeong, Feng, Chen, Bhunia, Anirban, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Integrins are involved in cell migration and adhesion. …”
Get full text
Get full text

Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells by Qu, Jing, Ero, Rya, Feng, Chen, Ong, Li-Teng, Tan, Hui-Foon, Lee, Hui-Shan, Ismail, Muhammad HB, Bu, Wen-Ting, Nama, Srikanth, Sampath, Prabha, Gao, Yong-Gui, Tan, Suet-Mien

Subjects: “…Extracellular matrix; Integrins…”
Get full text
Get full text

The systemic lupus erythematosus–associated single nucleotide polymorphism rs1143678 in integrin αM cytoplasmic tail generates a 14-3-3ζ binding site that is proinflammatory by Ong, Li-Teng, Tan, Hui-Foon, Feng, Chen, Qu, Jing, Loh, Shuzk-Cheng, Bhattacharyya, Surajit, Tan, Suet-Mien

“…The leukocyte integrin αMβ2 (CR3 or Mac-1) has both proinflammatory and immune regulatory functions. …”
Get full text
Get full text
Get full text

Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state by Bu, Wenting, Levitskaya, Zarina, Loh, Zhi Yang, Jin, Shengyang, Basu, Shibom, Ero, Rya, Yan, Xinfu, Wang, Meitian, Ngan, So Fong Cam, Sze, Siu Kwan, Tan, Suet-Mien, Gao, Yong-Gui

“…Kindlin-1, -2, and -3, directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. …”
Get full text

Emerging evidence for kindlin oligomerization and its role in regulating kindlin function by Bu, Wenting, Levitskaya, Zarina, Tan, Suet-Mien, Gao, Yong-Gui

“…Integrin-mediated cell-extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. …”
Get full text

NMR characterization and membrane interactions of the loop region of kindlin-3 F1 subdomain by Chua, Geok-Lin, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Kindlins-1,2 and 3 are FERM domain-containing cytosolic proteins involved in the activation and regulation of integrin-mediated cell adhesion. Apart from binding to integrin β cytosolic tails, kindlins and the well characterized integrin-activator talin bind membrane phospholipids. …”
Get full text
Get full text

The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation by Tan, Hui-Foon, Tan, Suet-Mien

“…Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. …”
Get full text