Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis. by Appel, H, Kuon, W, Kuhne, M, Wu, P, Kuhlmann, S, Kollnberger, S, Thiel, A, Bowness, P, Sieper, J

“…The application of HLA-B27 tetramers in HLA-B27-related diseases was performed with nine recently described Chlamydia-derived peptides in synovial fluid and peripheral blood, to examine the CD8+ T cell response against Chlamydia trachomatis antigens in nine patients with Chlamydia-triggered reactive arthritis (Ct-ReA). Four of six HLA-B27+ Ct-ReA patients had specific synovial T cell binding to at least one HLA-B27/Chlamydia peptide tetramer. …”

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis. by Appel, H, Kuon, W, Kuhne, M, Wu, P, Kuhlmann, S, Kollnberger, S, Thiel, A, Bowness, P, Sieper, J

“…The application of HLA-B27 tetramers in HLA-B27-related diseases was performed with nine recently described Chlamydia-derived peptides in synovial fluid and peripheral blood, to examine the CD8+ T cell response against Chlamydia trachomatis antigens in nine patients with Chlamydia-triggered reactive arthritis (Ct-ReA). Four of six HLA-B27+ Ct-ReA patients had specific synovial T cell binding to at least one HLA-B27/Chlamydia peptide tetramer. …”

Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases. by Kuon, W, Holzhütter, H, Appel, H, Grolms, M, Kollnberger, S, Traeder, A, Henklein, P, Weiss, E, Thiel, A, Lauster, R, Bowness, P, Radbruch, A, Kloetzel, P, Sieper, J

“…The association of HLA-B27 with ankylosing spondylitis and reactive arthritis is the strongest one known between an MHC class I Ag and a disease. …”