Infant excitation/inhibition balance interacts with executive attention to predict autistic traits in childhood by Virginia Carter Leno, Jannath Begum-Ali, Amy Goodwin, Luke Mason, Greg Pasco, Andrew Pickles, Shruti Garg, Jonathan Green, Tony Charman, Mark H. Johnson, Emily J. H. Jones, the EDEN, STAARS Teams

“…However, most studies have examined E/I alterations in older autistic individuals, meaning that findings could in part reflect homeostatic compensation. …”
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Facial expression recognition is linked to clinical and neurofunctional differences in autism by Hannah Meyer-Lindenberg, Carolin Moessnang, Bethany Oakley, Jumana Ahmad, Luke Mason, Emily J. H. Jones, Hannah L. Hayward, Jennifer Cooke, Daisy Crawley, Rosemary Holt, Julian Tillmann, Tony Charman, Simon Baron-Cohen, Tobias Banaschewski, Christian Beckmann, Heike Tost, Andreas Meyer-Lindenberg, Jan K. Buitelaar, Declan G. Murphy, Michael J. Brammer, Eva Loth

“…However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. …”
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Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure by Viola Hollestein, Geert Poelmans, Natalie J. Forde, Christian F. Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell’Acqua, Declan G. M. Murphy, Nicolaas A. Puts, Julian Tillmann, Tony Charman, Emily J. H. Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K. Buitelaar, Jilly Naaijen

“…The glutamate gene-set was associated with all autism symptom severity scores on the Autism Diagnostic Observation Schedule-2 (ADOS-2) and the Autism Diagnostic Interview-Revised (ADI-R) within the autistic group. In adolescents and adults, brain regions with greater gene-expression of glutamate and GABA genes showed greater differences in CT between autistic and neurotypical control participants although in opposing directions. …”
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Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study by Lennart M. Oblong, Alberto Llera, Ting Mei, Koen Haak, Christina Isakoglou, Dorothea L. Floris, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Simon Baron-Cohen, Eva Loth, Flavio Dell’Acqua, Tony Charman, Declan G. M. Murphy, Christine Ecker, Jan K. Buitelaar, Christian F. Beckmann, The EU-AIMS LEAP Group, Natalie J. Forde

“…We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n = 206) and non-autistic (n = 196) participants. …”
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The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings by Lisa M. Berg, Caroline Gurr, Johanna Leyhausen, Hanna Seelemeyer, Anke Bletsch, Tim Schaefer, Charlotte M. Pretzsch, Bethany Oakley, Eva Loth, Dorothea L. Floris, Jan K. Buitelaar, Christian F. Beckmann, Tobias Banaschewski, Tony Charman, Emily J. H. Jones, Julian Tillmann, Chris H. Chatham, Thomas Bourgeron, The EU-AIMS LEAP Group, Declan G. Murphy, Christine Ecker

“…This study aimed to (1) investigate between-group differences in autistic individuals with and without co-occurring ADHD, and to (2) link these variances to putative genomic underpinnings. …”
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Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers by Oliver Gale-Grant, Andrew Chew, Shona Falconer, Lucas G. S. França, Sunniva Fenn-Moltu, Laila Hadaya, Nicholas Harper, Judit Ciarrusta, Tony Charman, Declan Murphy, Tomoki Arichi, Grainne McAlonan, Chiara Nosarti, A. David Edwards, Dafnis Batalle

“…In this study we assess whether factors increasing the likelihood of childhood autism are related to early autistic trait emergence, or if other exposures are more important. …”
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Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project by Tristan Looden, Dorothea L. Floris, Alberto Llera, Roselyne J. Chauvin, Tony Charman, Tobias Banaschewski, Declan Murphy, Andre. F. Marquand, Jan K. Buitelaar, Christian F. Beckmann, the AIMS-2-TRIALS group

“…The similarity across individuals of the deviation pattern was significantly increased in autistic relative to TD individuals (p < 0.002). The CCA identified significant and robust brain-behavior covariation between functional connectivity atypicality and autism-related behavioral features. …”
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Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits by Christina Isakoglou, Koen V. Haak, Thomas Wolfers, Dorothea L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. Buitelaar, Andre F. Marquand, Christian F. Beckmann

“…We applied a data-driven approach to map the fine-grained variations in functional connectivity of the primary somatosensory cortex (S1) to the rest of the brain in 240 autistic and 164 neurotypical individuals from the EU-AIMS LEAP dataset, aged between 7 and 30. …”
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