Pre-operative inflammation and post-operative atrial fibrillation in coronary artery bypass surgery. by Paschalis, A, Tousoulis, D, Demosthenous, M, Antonopoulos, A, Papaioannou, S, Miliou, A, Koumallos, N, Antoniades, C, Stefanadis, C

Adiponectin As A Link Between Type 2 Diabetes Mellitus And Vascular NADPH-Oxidase Activity In The Human Arterial Wall: The Regulatory Role Of Perivascular Adipose Tissue. by Antonopoulos, A, Margaritis, M, Coutinho, P, Shirodaria, C, Psarros, C, Herdman, L, Sanna, F, De Silva, R, Petrou, M, Sayeed, R, Krasopoulos, G, Lee, R, Digby, J, Reilly, S, Bakogiannis, C, Tousoulis, D, Kessler, B, Casadei, B, Channon, K, Antoniades, C

“…Segments of internal mammary arteries (IMA) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue (Th-AT) were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH-oxidase-derived O2∙(-). …”

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition by Akoumianakis, I, Badi, I, Douglas, G, Chuaiphichai, S, Herdman, L, Akawi, N, Margaritis, M, Antonopoulos, A, Oikonomou, EK, Psarros, C, Galiatsatos, N, Tousoulis, D, Kardos, A, Sayeed, R, Krasopoulos, G, Petrou, M, Schwahn, U, Wohlfart, P, Tennagels, N, Channon, K, Antoniades, C

“…We studied 580 patients with coronary atherosclerosis undergoing coronary artery bypass surgery (CABG), finding that high endogenous insulin was associated with reduced nitric oxide (NO) bioavailability ex vivo in vessels obtained during surgery. …”

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”

Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. by Antoniades, C, Van-Assche, T, Shirodaria, C, Diesch, J, Antonopoulos, A, Lee, J, Cunnington, C, Tousoulis, D, Stefanadis, C, Casadei, B, Taggart, D, Channon, K, Leeson, P

“…BACKGROUND: The risk of atrial fibrillation (AF) after coronary bypass surgery has been related to redox state, inflammation, and ischemia. …”

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endotheli... by Antoniades, C, Shirodaria, C, Leeson, P, Antonopoulos, A, Warrick, N, Van-Assche, T, Cunnington, C, Tousoulis, D, Pillai, R, Ratnatunga, C, Stefanadis, C, Channon, K

“…METHODS AND RESULTS: Paired samples of saphenous veins (SVs) and internal mammary arteries (IMAs) were collected from 201 patients undergoing coronary bypass surgery, and serum ADMA was measured pre-operatively. …”