Development of an Ingestible Fluid Wicking Gastric Electrical Stimulation Platform for Hormone Modulation by McRae, James

“…Thus far, these methods have utilized invasive implant procedures in order to stimulate the outer muscle layers of the stomach. The development of non-invasive stimulation approaches requires that these systems be in an ingestible form factor that instead stimulate the inner mucosal layer of the stomach. …”
Get full text

Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics by Coffey, Jacob William, Gaiha, Gaurav Das, Traverso, Carlo Giovanni

“…The gastrointestinal (GI) tract presents a number of prospective mucosal inductive sites for vaccine targeting, including the oral cavity, stomach, and small intestine. However, currently available oral vaccines are effectively limited to live-attenuated and inactivated vaccines against enteric diseases. …”
Get full text

A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices by Zhu, Jiahua, Nash, Landon D., Maitland, Duncan J., Zhang, Shiyi, Bellinger, Andrew, Glettig, Dean, Barman, Ross, Lee, Young-Ah, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Langer, Robert S, Traverso, Carlo Giovanni

“…Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. …”
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text

Intragastric Mechanical Systems for Dysmotility Diagnosis and Obesity Treatment by Jia, Zixun

“…To address this, I have developed a motility mapping platform capable of 3D pressure distribution mapping within the stomach. This incorporates the development of new materials for sensors which can operate within the dynamic range of forces experienced in the GI tract, the mechanical framework to support engagement with gastric wall and the electronics to support sensing and recording of the contractile forces. …”
Get full text

Ingestible Electronics for High Quality Gastric Neural Recordings by Gierlach, Adam Matthew

“…The custom device and electrodes are designed to conform to the stomach wall, wirelessly transmit high quality signals, all while fitting in an ingestible form capable of being easily delivered into the GI tract. …”
Get full text

Ingestible hydrogel device by Liu, Xinyue, Steiger, Christoph Winfried Johannes, Lin, Shaoting, Parada Hernandez, German Alberto, Liu, Ji, Chan, Hon Fai, Yuk, Hyunwoo, Phan, Nhi V, Collins, Joy E, Tamang, Siddartha M, Traverso, Carlo Giovanni, Zhao, Xuanhe

“…Here, we introduce a hydrogel device that can be ingested as a standard-sized pill, swell rapidly into a large soft sphere, and maintain robustness under repeated mechanical loads in the stomach for up to one month. Large animal tests support the exceptional performance of the ingestible hydrogel device for long-term gastric retention and physiological monitoring.…”
Get full text

Prolonged energy harvesting for ingestible devices by Nadeau, Phillip, El-Damak, Dina Reda, Glettig, Dean, Kong, Yong Lin, Mo, Stacy H., Cleveland, Cody, Booth, Lucas, Roxhed, Niclas, Langer, Robert S, Chandrakasan, Anantha P, Traverso, Carlo Giovanni

“…Although previous biocompatible power-harvesting systems for in vivo use have demonstrated short (minute-long) bursts of power from the stomach, little is known about the potential for powering electronics in the longer term and throughout the gastrointestinal tract. …”
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text

Temperature-responsive biometamaterials for gastrointestinal applications by Babaee, Sahab, Pajovic, Simo, Kirtane, Ameya, Shi, Jiuyun, Caffarel Salvador, Ester, Hess, Kaitlyn, Collins, Joy E, Tamang, Siddartha M, Wahane, Aniket Vijay, Hayward, Alison M, Mazdiyasni, Hormoz, Langer, Robert S, Traverso, Carlo Giovanni

“…For the extra-esophageal compartment, we developed a highly flexible macrostructure (mechanical metamaterial) that deforms into a cylindrical shape to safely pass through the esophagus and deploys into a fenestrated spherical shape in the stomach, capable of residing safely in the gastric cavity for weeks. …”
Get full text

Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals by Bellinger, Andrew, Jafari, Mousa, Grant, Tyler M, Zhang, Shiyi, Slater, Hannah C., Wenger, Edward A., Mo, Stacy H., Lee, Young-Ah, Mazdiyasni, Hormoz, Barman, Ross, Kogan, Lawrence, Cleveland, Cody, Booth, Lucas, Bensel, Taylor A, Minahan Jr, Daniel J, Hurowitz, Haley M., Tai, Tammy, Daily, Johanna, Nikolic, Boris, Wood, Lowell, Eckhoff, Philip A., Langer, Robert S, Traverso, Carlo Giovanni

“…We have developed an oral, ultra-long-acting capsule that dissolves in the stomach and deploys a star-shaped dosage form that releases drug while assuming a geometry that prevents passage through the pylorus yet allows passage of food, enabling prolonged gastric residence. …”
Get full text

Real-Time Radiation Detection within the Gastrointestinal Tract by McLymore, Crystan

“…An in vivo study was then performed in which the encapsulated diode was placed in a swine’s stomach, and 110 kVp X-ray images were captured of the swine’s abdominal region. …”
Get full text

Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine by Verma, Malvika, Chu, Jacqueline N, Salama, John Ashraf Fou, Faiz, Mohammed T., Eweje, Feyisope, Gwynne, Declan A, Lopes, Aaron C, Hess, Kaitlyn, Soares, Vance, Steiger, Christoph Winfried Johannes, McManus, Rebecca S, Koeppen, Ryan P., Hua, Tiffany P, Hayward, Alison M, Collins, Joy E, Tamang, Siddartha M, Ishida, Keiko, Miller, Jonathan B., Katz, Stephanie, Slocum, Alexander H, Sulkowski, Mark S., Thomas, David L., Langer, Robert S, Traverso, Carlo Giovanni

“…We designed a retrievable coil-shaped LA-DAAS compatible with nasogastric tube administration and the capacity to encapsulate and release gram levels of drugs while resident in the stomach. We formulated DAAs in drug-polymer pills and studied the release kinetics for 1 mo in vitro and in vivo in a swine model. …”
Get full text

Scalable Gastric Resident Systems for Veterinary Application by Hayward, Alison M, Bensel, Taylor A, Mazdiyasni, Hormoz, Rogner, Jaimie L, Kirtane, Ameya, Lee, Young-Ah, Hua, Tiffany P, Bajpayee, Ambika Goel, Collins, Joy E, McDonnell, Shane, Cleveland, Cody, Lopes, Aaron C, Wahane, Aniket Vijay, Langer, Robert S, Traverso, Carlo Giovanni

“…We investigate prototypes in dimensions consistent with administration and retention in the stomachs of two species (rabbit and pig). We investigate sustained gastric retention of our scalable dosage form platform, and in pigs show the capacity to modulate drug release kinetics of a model drug in veterinary practice, meloxicam, with our dosage form. …”
Get full text
Get full text
Get full text
Get full text