Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa by Dass, S, Cochlin, L, Suttie, J, Holloway, C, Rodgers, C, Tyler, D, Karamitsos, T, Clarke, K, Watkins, H, Neubauer, S

“…The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal models and in patients with HCM.Hypothesis: Our hypothesis is that the high incidence of exercise-related death in HCM may be explained by an acute impairment of myocardial energetics. …”

The development and application of new hyperpolarized magnetic resonance spectroscopy techniques for the non-invasive assessment of metabolism in the rodent heart by Dodd, MS

“…This requires the study of genetically modified animals, namely transgenic mouse models. …”