Showing 1 - 20 results of 20 for search '"lymphoma"', query time: 0.10s Refine Results
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    Chimeric antigen receptor‐T cell therapy shows similar efficacy and toxicity in patients with diffuse large B‐cell lymphoma aged 70 and older compared to younger patients: A multicenter cohort study by Philipp Berning, Evgenii Shumilov, Markus Maulhardt, Hristo Boyadzhiev, Andrea Kerkhoff, Simon Call, Christian Reicherts, Anna O. Saidy, Enver Aydilek, Michèle Hoffmann, Urban Novak, Michael Daskalakis, Norbert Schmitz, Matthias Stelljes, Gerald Wulf, Ulrike Bacher, Georg Lenz, Thomas Pabst

    Published 2024-03-01
    “…Abstract CD19‐directed chimeric antigen receptor (CAR)‐T cell therapy has become a standard treatment for relapsed/refractory diffuse large B‐cell lymphoma (r/r DLBCL). While the benefits of CAR‐T cell treatment are clear in the general patient population, there remains a relative scarcity of real‐world evidence regarding its efficacy and toxicity in patients (pts) aged ≥70 years with DLBCL. …”
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    The Evolving Treatment Landscape of AML by Sabine Blum, Ulrike Bacher, Thomas Pabst

    Published 2022-03-01
    “…Over the last years, B-cell lymphoma-2 (BCL-2), a key regulator of the intrinsic apoptotic pathway, has also emerged as a relevant target for therapy for many diseases including AML, and promising results were reported with the use of BCL-2 inhibitors. …”
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    CAR-T Cell Therapy Shows Similar Efficacy and Toxicity in Patients With DLBCL Regardless of CNS Involvement by Evgenii Shumilov, Hristo Boyadzhiev, Paolo Mazzeo, Dilara Akhoundova, Michael Daskalakis, Urban Novak, Georg Lenz, Ulrike Bacher, Thomas Pabst

    Published 2023-12-01
    “…Efficacy and toxicity of chimeric antigen receptor T (CAR-T) cell therapy in relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) involvement remain understudied. …”
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    Clinical Impact of Single Nucleotide Polymorphism in CD-19 on Treatment Outcome in FMC63-CAR-T Cell Therapy by Katja Seipel, Mariesol Abbühl, Ulrike Bacher, Henning Nilius, Michael Daskalakis, Thomas Pabst

    Published 2023-06-01
    “…Chimeric antigen receptor (CAR)-T cell therapy is effective in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) with response rates of 63–84% and complete response observed in 43–54%. …”
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    BeEAM High-Dose Chemotherapy with Polatuzumab (Pola-BeEAM) before ASCT in Patients with DLBCL—A Pilot Study by Tanja Stoffel, Ulrike Bacher, Yara Banz, Michael Daskalakis, Urban Novak, Thomas Pabst

    Published 2022-06-01
    “…(1) Introduction: BEAM is a high-dose chemotherapy (HDCT) frequently administered before autologous stem cell transplantation (ASCT) in diffuse large B-cell lymphoma (DLBCL). Bendamustine replacing BCNU (BeEAM) is similarly effective at lower toxicities. …”
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    Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia by Katja Seipel, Karin Schmitter, Ulrike Bacher, Thomas Pabst

    Published 2019-11-01
    “…Here, we assessed the MCL1-antagonist S63845, the MDM2-inhibitor HDM201, and the MEK1/2-inhibitor trametinib as single agents and in combination in a variety of AML cell lines and mononuclear cells isolated from patients with hematological malignancies centered on myeloid leukemia, some lymphatic leukemia, as well as some lymphomas, for their ability to induce apoptosis and cell death. …”
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