Amnesia, cerebral atrophy, and autoimmunity. by Schott, J, Harkness, K, Barnes, J, della Rocchetta, A, Vincent, A, Rossor, M

RETROGRADE AMNESIA FOLLOWING AUTOIMMUNE LIMBIC ENCEPHALITIS by Miller, T, Gowland, P, Johnson, M, Irani, S, Davies, A, Jacob, S, Maddison, P, Husain, M, Butler, C, Kennard, C, Vincent, A, Rosenthal, C

Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex. by Butler, C, Miller, T, Kaur, MS, Baker, I, Boothroyd, G, Illman, N, Rosenthal, C, Vincent, A, Buckley, C

“…CONCLUSIONS: The results show that, despite broad cognitive dysfunction in the acute phase, patients with VGKC-LE often make a substantial recovery with immunotherapy but may be left with permanent anterograde amnesia.…”

Temporal lobe seizures, amnesia and autoantibodies - identifying a potentially reversible form of non-paraneoplastic limbic encephalitis. by Vincent, A, Bien, C

Hypothermia in VGKC antibody-associated limbic encephalitis. by Jacob, S, Irani, SR, Rajabally, Y, Grubneac, A, Walters, R, Yazaki, M, Clover, L, Vincent, A

“…Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures.…”

Non-paraneoplastic limbic encephalitis characterized by mesio-temporal seizures and extratemporal lesions: a case report. by Cianci, V, Labate, A, Lanza, P, Vincent, A, Gambardella, A, Branca, D, Arcudi, L, Aguglia, U

“…Here we describe a 27-year-old woman whose idiopathic autoimmune (glutamic acid decarboxylase-antibody positive) LE debuted with multiple daily mesio-temporal seizures, amnesia and multifocal extratemporal cortical MRI abnormalities. …”

FDG-PET and MRI in potassium channel antibody-associated non-paraneoplastic limbic encephalitis: correlation with clinical course and neuropsychology. by Fauser, S, Talazko, J, Wagner, K, Ziyeh, S, Jarius, S, Vincent, A, Schulze-Bonhage, A

“…CASE SUMMARY: A 32-year-old woman suffered from prolonged global amnesia after two generalized tonic-clonic seizures due to NPLE. …”

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. by Irani, SR, Michell, A, Lang, B, Pettingill, P, Waters, P, Johnson, MR, Schott, J, Armstrong, R, S Zagami, A, Bleasel, A, Somerville, E, Smith, S, Vincent, A

“…Whereas 3 patients never developed LE, 20 of the remaining 26 (77%) experienced FBDS prior to the development of the amnesia and confusion that characterize LE. During the prodrome of FBDS alone, patients had normal sodium and brain MRIs, but electroencephalography demonstrated ictal epileptiform activity in 7 patients (24%). …”

Antibodies to voltage-gated potassium and calcium channels in epilepsy. by Majoie, H, de Baets, M, Renier, W, Lang, B, Vincent, A

“…BACKGROUND: Although the CNS is thought to be protected from circulating antibodies by the blood brain barrier, glutamate receptor antibodies have been reported in Rasmussen's encephalitis, glutamic acid decarboxylase (GAD) antibodies have been found in a few patients with epilepsy, and antibodies to voltage-gated potassium channels (VGKC) have been found in a non-paraneoplastic form of limbic encephalitis (with amnesia and seizures) that responds to immunosuppressive therapy. …”

Autoantibodies in Alzheimer disease;. by Nilforooshan, R, Vincent, A, Eccles, J, Pettingill, R, Pettingill, P, Ali, L, Tabet, N

“…CONCLUSION: It is still unclear for how long these antibodies are being identified in acute onset of many neurological diseases including amnesia or psychosis. We know that pathophysiology of AD starts many years before the clinical presentations. …”

Morvan syndrome: clinical and serological observations in 29 cases. by Irani, SR, Pettingill, P, Kleopa, K, Schiza, N, Waters, P, Mazia, C, Zuliani, L, Watanabe, O, Lang, B, Buckley, C, Vincent, A

“…RESULTS: Neuromyotonia (100%), neuropsychiatric features (insomnia 89.7%, confusion 65.5%, amnesia 55.6%, hallucinations 51.9%), dysautonomia (hyperhidrosis 86.2%, cardiovascular 48.3%), and neuropathic pain (62.1%) were the most common manifestations. …”

Potassium channel antibody-associated encephalopathy: A potentially immunotherapy-responsive form of limbic encephalitis by Vincent, A, Buckley, C, Schott, J, Baker, I, Dewar, B, Detert, N, Clover, L, Parkinson, A, Bien, C, Omer, S, Lang, B, Rossor, M, Palace, J

“…Patients presenting with subacute amnesia are frequently seen in acute neurological practice. …”

Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. by Vincent, A, Buckley, C, Schott, J, Baker, I, Dewar, B, Detert, N, Clover, L, Parkinson, A, Bien, C, Omer, S, Lang, B, Rossor, M, Palace, J

“…Patients presenting with subacute amnesia are frequently seen in acute neurological practice. …”