Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. by Grote, V, Kaaks, R, Nieters, A, Tjønneland, A, Halkjær, J, Overvad, K, Skjelbo Nielsen, MR, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodríguez, L, Duell, E, Sánchez, M

“…METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. …”

KIM-1 as a blood-based marker for early detection of kidney cancer: a prospective nested case–control study by Scelo, G, Muller, DC, Riboli, E, Johansson, M, Cross, AJ, Vineis, P, Tsilidis, KK, Brennan, P, Boeing, H, Peeters, PHM, Vermeulen, RCH, Overvad, K, Bueno-De-Mesquita, HB, Severi, G, Perduca, V, Kvaskoff, M, Trichopoulou, A, La Vecchia, C, Karakatsani, A, Palli, D, Sieri, S, Panico, S, Weiderpass, E, Sandanger, TM, Nøst, TH, Agudo, A, Quirós, JR, Rodríguez-Barranco, M, Chirlaque, M-D, Key, TJ, Khanna, P, Bonventre, JV, Sabbisetti, VS, Bhatt, RS

“…</p> <p><strong>Experimental Design:</strong> KIM-1 concentrations were measured in prediagnostic plasma from 190 RCC cases and 190 controls nested within a population-based prospective cohort study. …”

Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Travis, R, Crowe, F, Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Olsen, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Dilis, V, Trichopoulos, D, Vineis, P, Palli, D, Tumino, R, Sieri, S, Bueno-de-Mesquita, H, van Duijnhoven, F, Chirlaque, MD, Barricarte, A, Larrañaga, N, González, C, Argüelles, M, Sánchez, M, Stattin, P, Hallmans, G, Khaw, K, Bingham, S, Rinaldi, S, Slimani, N, Jenab, M, Riboli, E, Key, T

“…The authors examined whether vitamin D concentrations were associated with prostate cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (1994-2000). …”

Primary brain tumours and specific serum immunoglobulin E: A case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-De-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…Methods: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort. by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-de-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…METHODS: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

Serum vitamin d and risk of prostate cancer in a case-control analysis nested within the european prospective investigation into cancer and nutrition (EPIC) by Travis, R, Crowe, F, Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Olsen, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Dilis, V, Trichopoulos, D, Vineis, P, Palli, D, Tumino, R, Sieri, S, Bueno-De-Mesquita, H, Van Duijnhoven, F, Chirlaque, M, Barricarte, A, Larrañaga, N, González, C, Argüelles, M

“…The authors examined whether vitamin D concentrations were associated with prostate cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (1994-2000). …”

Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. by Leufkens, A, van Duijnhoven, F, Woudt, S, Siersema, P, Jenab, M, Jansen, E, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V

“…This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study by Chambers, JC, Loh, M, Lehne, B, Drong, A, Kriebel, J, Motta, V, Wahl, S, Elliott, HR, Rota, F, Scott, WR, Zhang, W, Tan, S-T, Campanella, G, Chadeau-Hyam, M, Yengo, L, Richmond, RC, Adamowicz-Brice, M, Afzal, U, Bozaoglu, K, Mok, ZY, Ng, HK, Pattou, F, Prokisch, H, Rozario, MA, Tarantini, L, Abbott, J, Ala-Korpela, M, Albetti, B, Ammerpohl, O, Bertazzi, PA, Blancher, C, Caiazzo, R, Danesh, J, Gaunt, TR, De Lusignan, S, Gieger, C, Illig, T, Jha, S, Jones, S, Jowett, J, Kangas, AJ, Kasturiratne, A, Kato, N, Kotea, N, Kowlessur, S, Pitkäniemi, J, Punjabi, P, Saleheen, D, Schafmayer, C, Soininen, P, Tai, ES, Thorand, B, Tuomilehto, J, Wickremasinghe, AR, Kyrtopoulos, SA, Aitman, TJ, Herder, C, Hampe, J, Cauchi, S, Relton, CL, Froguel, P, Soong, R, Vineis, P, Jarvelin, MR, Scott, J, Grallert, H, Bollati, V, Elliott, P, McCarthy, MI, Kooner, JS

“…</p> <p><strong>Methods</strong> We did a nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population (LOLIPOP) study. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Dossus, L, McKay, J, Canzian, F, Wilkening, S, Rinaldi, S, Biessy, C, Olsen, A, Tjønneland, A, Jakobsen, M, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fournier, A, Linseisen, J, Lukanova, A, Boeing, H, Fisher, E, Trichopoulou, A, Georgila, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Quirós, JR

“…We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. …”

Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). by Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, V, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, H, Peeters, P

“…Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. …”

Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Key, T, Allen, N, Appleby, P, Roddam, A, Rinaldi, S, Egevad, L, Gann, P, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Sieri, S, Vineis, P, Palli, D, Quirós, JR, Ardanaz, E

“…We examined the hypothesis that serum concentrations of circulating androgens and sex hormone binding globulin (SHBG) are associated with risk for prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

A1.5 Smoking is a risk factor for ACPA prior to onset of symptoms of rheumatoid arthritis in a cohort from southern europe. by Cartwright, A, Quirke, A, de Pablo, P, Romaguera, D, Panico, S, Mattiello, A, Gavrila, D, Navarro, C, Sacerdote, C, Vineis, P, Tumino, R, Michaud, D, Riboli, E, Fisher, B, Venables, P

“…In this study we examined the immune response to citrullinated antigens and a detailed smoking history, in a nested case-control study of subjects enrolled in the European Prospective Investigation into Cancer (EPIC) project who later developed RA.…”

Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). by Nagel, G, Linseisen, J, Boshuizen, H, Pera, G, Del Giudice, G, Westert, G, Bueno-de-Mesquita, H, Allen, N, Key, T, Numans, M, Peeters, P, Sieri, S, Siman, H, Berglund, G, Hallmans, G, Stenling, R, Martinez, C, Arriola, L, Barricarte, A, Chirlaque, MD, Quiros, JR, Vineis, P, Masala, G, Palli, D, Panico, S

“…We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. …”

Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC Cohort by Carayol, M, Leitzmann, MF, Ferrari, P, Zamora-Ros, R, Achaintre, D, Stepien, M, Schmidt, JA, Travis, RC, Overvad, K, Tjønneland, A, Hansen, L, Kaaks, R, Kühn, T, Boeing, H, Bachlechner, U, Trichopoulou, A, Bamia, C, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Quirós, JR, Sánchez-Cantalejo, E, Huerta, JM, Ardanaz, E, Arriola, L, Agudo, A, Nilsson, J, Melander, O, Bueno-de-Mesquita, B, Peeters, PH, Wareham, N, Khaw, KT, Jenab, M, Key, TJ, Scalbert, A, Rinaldi, S

“…Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). …”

Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition by Perez-Cornago, A, Appleby, P, Tipper, S, Key, T, Allen, N, Nieters, A, Vermeulen, R, Roulland, S, Casabonne, D, Kaaks, R, Fortner, R, Boeing, H, Trichopoulou, A, La Vecchia, C, Klinaki, E, Hansen, L, Tjønneland, A, Bonnet, F, Fagherazzi, G, Boutron-Ruault, M, Pala, V, Masala, G, Sacerdote, C, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Dorronsoro, M, Quirós, J, Barricarte, A, Gavrila, D, Agudo, A, Borgquist, S, Rosendahl, A, Melin, B, Wareham, N, Khaw, K, Gunter, M, Riboli, E, Vineis, P, Travis, R

“…IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1072 cases of lymphoid malignancies and 1072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. …”

Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. by Vineis, P, Veglia, F, Garte, S, Malaveille, C, Matullo, G, Dunning, A, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Kaaks, R, Boeing, H, Trichopoulou, A, Palli, D, Crosignani, P, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Gonzalez, C, Martinez, C, Dorronsoro, M

“…PATIENTS AND METHODS: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). …”

European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. by Riboli, E, Hunt, K, Slimani, N, Ferrari, P, Norat, T, Fahey, M, Charrondière, U, Hémon, B, Casagrande, C, Vignat, J, Overvad, K, Tjønneland, A, Clavel-Chapelon, F, Thiébaut, A, Wahrendorf, J, Boeing, H, Trichopoulos, D, Trichopoulou, A, Vineis, P, Palli, D, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Engeset, D, González, C

“…First results of case-control studies nested within the cohort are expected early in 2003. …”