Identification of novel serodiagnostic signatures of typhoid fever using a salmonella proteome array by Darton, T, Baker, S, Randall, A, Dongol, S, Karkey, A, Voysey, M, Carter, M, Jones, C, Trappl, K, Pablo, J, Hung, C, Teng, A, Shandling, A, Le, T, Walker, C, Molina, D, Andrews, J, Arjyal, A, Basnyat, B, Pollard, A, Blohmke, C

“…Current diagnostic tests for typhoid fever, the disease caused by Salmonella Typhi, are poor. …”

A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data by Phillips, MT, Meiring, JE, Voysey, M, Warren, JL, Baker, S, Basnyat, B, Clemens, JD, Dolecek, C, Dunstan, SJ, Dougan, G, Gordon, MA, Thindwa, D, Heyderman, RS, Holt, KE, Qadri, F, Pollard, AJ, Pitzer, VE

“…Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. …”

Assessment of vaccine herd protection in a cluster-randomised trial of Vi conjugate vaccine against typhoid fever: results of further analysis by Khanam, F, Kim, DR, Liu, X, Voysey, M, Pitzer, VE, Zaman, K, Pollard, AJ, Qadri, F, Clemens, JD

“…Vi-TT protection against typhoid fever, detected at 8 treatment centres serving the study population, was compared in the original clusters for the trial, and for progressively more central subclusters (“yolks” of the “fried egg”) of the cluster residents. …”

Protection by vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh: a cluster-randomised trial by Qadri, F, Khanam, F, Liu, X, Theiss-Nyland, K, Biswas, PK, Bhuiyan, AI, Ahmmed, F, Colin-Jones, R, Smith, N, Tonks, S, Voysey, M, Mujadidi, YF, Mazur, O, Rajib, NH, Hossen, MI, Ahmed, SU, Khan, A, Rahman, N, Babu, G, Greenland, M, Kelly, S, Ireen, M, Islam, K, O'Reilly, P, Scherrer, KS, Pitzer, VE, Neuzil, KM, Zaman, K, Pollard, AJ, Clemens, JD

“…<p><strong>Background</strong></p> Typhoid fever remains a major cause of morbidity and mortality in low-income and middle-income countries. …”

The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) Population-based Enteric Fever Studies: a review of methodological similarities and differences by Carey, ME, MacWright, WR, Im, J, Meiring, JE, Gibani, MM, Park, SE, Longley, A, Jeon, HJ, Hemlock, C, Yu, AT, Soura, A, Aiemjoy, K, Owusu-Dabo, E, Terferi, M, Islam, S, Lunguya, O, Jacobs, J, Gordon, M, Dolecek, C, Baker, S, Pitzer, VE, Yousafzai, MT, Tonks, S, Clemens, JD, Date, K, Qadri, F, Heyderman, RS, Saha, SK, Basnyat, B, Okeke, IN, Qamar, FN, Voysey, M, Luby, S, Kang, G, Andrews, J, Pollard, AJ, John, J, Garrett, D, Marks, F

Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial by Shakya, M, Voysey, M, Theiss-Nyland, K, Colin-Jones, R, Pant, D, Adhikari, A, Tonks, S, Mujadidi, YF, O'Reilly, P, Mazur, O, Kelly, S, Liu, X, Maharjan, A, Dahal, A, Haque, N, Pradhan, A, Shrestha, S, Joshi, M, Smith, N, Hill, J, Clarke, J, Stockdale, L, Jones, E, Lubinda, T, Bajracharya, B, Dongol, S, Karkey, A, Baker, S, Dougan, G, Pitzer, VE, Neuzil, KM, Shrestha, S, Basnyat, B, Pollard, AJ

“…<br><strong>Background<br></strong> Typhoid fever is a major public health problem in low-resource settings. …”

Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal by Shakya, M, Colin-Jones, R, Theiss-Nyland, K, Voysey, M, Pant, D, Smith, N, Liu, X, Tonks, S, Mazur, O, Farooq, YG, Clarke, J, Hill, J, Adhikari, A, Dongol, S, Karkey, A, Bajracharya, B, Kelly, S, Gurung, M, Baker, S, Neuzil, K, Shretha, S, Basnyat, B, Pollard, AJ

“…The primary outcome was typhoid fever confirmed by blood culture. We present the prespecified analysis of the primary and main secondary outcomes (including an immunogenicity subgroup); the 2-year trial follow-up is ongoing.…”

Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal by Shakya, M, Colin-Jones, R, Theiss-Nyland, K, Voysey, M, Pant, D, Smith, N, Liu, X, Tonks, S, Mazur, O, Farooq, YG, Clarke, J, Hill, J, Adhikari, A, Dongol, S, Karkey, A, Bajracharya, B, Kelly, S, Gurung, M, Baker, S, Neuzil, KM, Shrestha, S, Basnyat, B, Pollard, AJ, Tyvac Nepal Study Team

“…The primary outcome was typhoid fever confirmed by blood culture. We present the prespecified analysis of the primary and main secondary outcomes (including an immunogenicity subgroup); the 2-year trial follow-up is ongoing.…”

Logistics of implementing a large-scale typhoid vaccine trial in Kathmandu, Nepal by Colin-Jones, R, Shakya, M, Voysey, M, Theiss-Nyland, K, Smith, N, Pant, D, Liu, X, Tonks, S, Mazur, O, Farooq, Y, Kelly, S, Adhikari, A, Dongol, S, Karkey, A, Shrestha, S, Basnyat, B, Pollard, A

“…Typhoid fever is estimated to affect over 20 million people per year worldwide, with infants, children, and adolescents in south-central and southeast Asia experiencing the greatest burden of disease. …”

Association of antibody-dependent neutrophil phagocytosis with distinct antibody glycosylation profiles following typhoid vaccination by Johnson, M, Stockdale, LK, de Haan, N, Wuhrer, M, Nouta, J, Koeleman, CAM, Clarke, J, Marinou, S, Shakya, M, Colin-Jones, R, Theiss-Nyland, K, Voysey, M, Jin, C, Pant, D, Jones, E, Kelly, S, Dongol, S, Karkey, A, Shrestha, S, Basnyat, B, Hill, J, Pollard, AJ

“…Typhoid Vi-conjugate vaccines (Vi-TCV) have been developed to control typhoid fever in children in endemic regions. Previously, in a human challenge model of typhoid, Vi-TCV was administered prior to deliberate ingestion of Salmonella Typhi by healthy adult volunteers in the UK. …”

Assessing the impact of a Vi-polysaccharide conjugate vaccine in preventing typhoid infection among Bangladeshi children: A protocol for a phase IIIb trial by Theiss-Nyland, K, Qadri, F, Colin-Jones, R, Zaman, K, Khanam, F, Liu, X, Voysey, M, Khan, A, Hasan, N, Ashher, F, Farooq, Y, Pollard, A, Clemens, J

“…Typhoid fever illnesses are responsible for more than 100 000 deaths worldwide each year. …”

Under-detection of blood culture-positive enteric fever cases: The impact of missing data and methods for adjusting incidence estimates by Voysey, M, Pant, D, Shakya, M, Liu, X, Colin-Jones, R, Theiss-Nyland, K, Smith, N, Shrestha, S, Basnyat, B, Pollard, A, Pitzer, V

“…<p><strong>Background:</strong>In surveillance for typhoid fever, under-detection of cases occurs when patients with fever do not seek medical care, or seek medical care but do not receive a blood test. …”

The design and analysis of seroefficacy studies for typhoid conjugate vaccines by Liu, X, Pitzer, V, Pollard, A, Voysey, M

“…<br/><br/> <strong>Conclusion</strong> Seroefficacy trials can establish the efficacy of new conjugate vaccines using small trials enrolling hundreds rather than thousands of participants, and without the need for resource-intensive typhoid fever surveillance programmes.…”