Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice by Ho K. Lee, Jinhong Park, Bo-Rahm Kim, Ikhyun Jun, Tae-im Kim, Wan Namkung

“…Isorhamnetin did not alter intracellular cAMP levels and the activity of other ion channels, including ANO1, ENaC, and hERG. Notably, application of isorhamnetin on mouse ocular surface induced CFTR activation and increased tear volume. …”
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Novel CFTR Activator Cact-3 Ameliorates Ocular Surface Dysfunctions in Scopolamine-Induced Dry Eye Mice by Dongkyu Jeon, Ikhyun Jun, Ho K. Lee, Jinhong Park, Bo-Rahm Kim, Kunhi Ryu, Hongchul Yoon, Tae-im Kim, Wan Namkung

“…Among them, the most potent CFTR activator, Cact-3 (7-(3,4-dimethoxyphenyl)-N-(4-ethoxyphenyl)pyrazolo [1,5-α]pyrimidine-2-carboxamide), produced large and sustained Cl⁻ currents in WT-CFTR-expressing FRT cells with no alterations of ANO1 and hERG channel activity. The application of Cact-3 strongly activated CFTR in the ocular epithelia of mice and it also significantly increased CFTR-mediated Cl⁻ transport in a primary cultured human conjunctival epithelium. …”
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Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential by Yohan Seo, Sion Lee, Minuk Kim, Dongguk Kim, Sung Baek Jeong, Raju Das, Armin Sultana, SeonJu Park, Nguyen Xuan Nhiem, Phan Thi Thanh Huong, Oh-Bin Kwon, Wan Namkung, Joohan Woo, Joohan Woo

“…Moreover, it exhibited minimal toxicity to liver cells and did not affect hERG channel activity, making it a promising candidate for further development as an anticancer drug.Conclusion: Vitekwangin B may offer a new direction for cancer therapy by targeting ANO1 protein, potentially improving treatment outcomes in patients with prostate cancer and NSCLC. …”
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VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1 by Dongkyu Jeon, Kunhi Ryu, Sungwoo Jo, Ikyon Kim, Wan Namkung

“…In addition, VI-116 showed minimal effect on hERG K⁺ channel activity up to 10 μM. …”
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Anticancer effect of verteporfin on non-small cell lung cancer via downregulation of ANO1 by Sung Baek Jeong, Raju Das, Dong-Hyun Kim, Sion Lee, Hye In Oh, Sungwoo Jo, Yechan Lee, Jeongdong Kim, SeonJu Park, Dong Kyu Choi, Uk Yeol Moon, Oh-bin Kwon, Wan Namkung, Sungwoo Lee, Byoung Chul Cho, Joohan Woo, Yohan Seo

“…However, it did not affect hERG channel activity. These results show that the anticancer mechanism of verteporfin is caused via the down-regulation of ANO1.…”
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