Combination Strategy of Genetic Dereplication and Manipulation of Epigenetic Regulators Reveals a Novel Compound from Plant Endophytic Fungus by Lu Yang, Guangwei Wu, Fanyue Meng, Huomiao Ran, Wenbing Yin, Wei Li, Xiaoqing Liu

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Nucleosome Dynamics Derived at the Single-Molecule Level Bridges Its Structures and Functions by Ping Chen, Guohong Li, Wei Li

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Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation by Jiayu Liu, Chuanrong Zhao, Xue Xiao, Aohan Li, Yueqi Liu, Jianan Zhao, Linwei Fan, Zhenhui Liang, Wei Pang, Weijuan Yao, Wei Li, Jing Zhou

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The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury by Xinzhou Yan, Yuqi Xia, Bojun Li, Zehua Ye, Lei Li, Tianhui Yuan, Baofeng Song, Weimin Yu, Ting Rao, Jinzhuo Ning, Fangyou Lin, Shuqin Mei, Zhiguo Mao, Xiangjun Zhou, Wei Li, Fan Cheng

“…However, the role of epigenetic regulation in calcium oxalate (CaOx) crystal deposition-induced kidney injury remains unclear. …”
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Multiple functions of m6A RNA methylation in cancer by Yutian Pan, Pei Ma, Yu Liu, Wei Li, Yongqian Shu

“…Modifications of m6A are dynamic and reversible in mammalian cells, which have been proposed as another layer of epigenetic regulation similar to DNA and histone modifications. m6A RNA methylation is involved in all stages in the life cycle of RNA, ranging from RNA processing, through nuclear export, translation modulation to RNA degradation, which suggests its potential of influencing a plurality of aspects of RNA metabolism. …”
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Regulatory Mechanisms of lncRNAs and Their Target Gene Signaling Pathways in Laryngeal Squamous Cell Carcinoma by Wei Li, Yu Chen, Xuqiang Nie, Xuqiang Nie

“…Previous researches have demonstrated that long noncoding RNAs (lncRNAs) can be used as oncogenes or tumor suppressor genes in the occurrence and development of cancer and regulate cancer through various ways including epigenetic regulation and post-transcriptional regulation. …”
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Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis by Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang

“…Th17 cells produce a range of characteristic Th17 type cytokines and express transcription factors governed by epigenetic regulation to engage the Th17 programme. Here the authors implicate the RNA 5- methylcytosine (m5C) methyltransferase Nsun2 in Th17 cells and the promotion of colitis in a murine model.…”
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H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development by Xiaolong Chen, Youqiong Ye, Liang Gu, Jin Sun, Yanhua Du, Wen-Ju Liu, Wei Li, Xiaobai Zhang, Cizhong Jiang

“…Drosophila neural development undergoes extensive chromatin remodeling and precise epigenetic regulation. However, the roles of chromatin remodeling in establishment and maintenance of cell identity during cell fate transition remain enigmatic. …”
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Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer by Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li, Lanlan Shen

“…We tested whether anti-PD-L1 immunotherapy affects overall survival of tumor-bearing mice and whether inhibition of both epigenetic regulation and immune checkpoint is more efficacious. …”
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