Single dose oral gabapentin for established acute postoperative pain in adults. by Straube, S, Derry, S, Moore, R, Wiffen, P, McQuay, H

“…SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE, and the Oxford Pain Relief Database. Additional studies were sought from reference lists of retrieved articles and reviews. …”

Relative efficacy of oral analgesics after third molar extraction--a 2011 update. by Derry, S, Wiffen, P, Moore, R

“…It will help clinicians and patients make informed choices about analgesia based on pain relief, duration of action, and adverse events, which can then be put into context for the individual patient, depending on local availability. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Transdermal fentanyl for cancer pain. by Hadley, G, Derry, S, Moore, R, Wiffen, P

“…OBJECTIVES: To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain. …”

Pregabalin for acute and chronic pain in adults. by Moore, R, Straube, S, Wiffen, P, Derry, S, McQuay, H

“…Efficacy was demonstrated for dichotomous outcomes equating to moderate or substantial pain relief, alongside lower rates for lack of efficacy discontinuations with increasing dose. …”

Pregabalin for acute and chronic pain in adults. by Moore, R, Straube, S, Wiffen, P, Derry, S, McQuay, H

“…Efficacy was demonstrated for dichotomous outcomes equating to moderate or substantial pain relief, alongside lower rates for lack of efficacy discontinuations with increasing dose. …”

Oral morphine for cancer pain. by Wiffen, P, Wee, B, Moore, R

“…Eighteen studies achieved this level of pain relief on average, and no study reported that good levels of pain relief were not attained. …”

Lamotrigine for acute and chronic pain. by Wiffen, P, Derry, S, Moore, R

“…Assessment of pain intensity or pain relief, or both, using validated scales. Participants were adults aged 18 and over. …”

Gabapentin for chronic neuropathic pain and fibromyalgia in adults. by Moore, R, Wiffen, P, Derry, S, McQuay, H

“…AUTHORS' CONCLUSIONS: Gabapentin provides pain relief of a high level in about a third of people who take if for painful neuropathic pain. …”

Lamotrigine for chronic neuropathic pain and fibromyalgia in adults. by Wiffen, P, Derry, S, Moore, R

“…Assessment of pain intensity or pain relief, or both, using validated scales. Participants were adults aged 18 and over. …”

Challenges in design and interpretation of chronic pain trials. by Moore, R, Derry, S, Wiffen, P

“…Patients want outcomes of low pain scores, large reductions in pain and relief from associated symptoms, with improvements in ability to function and in quality of life. …”

Amitriptyline for neuropathic pain and fibromyalgia in adults. by Moore, R, Derry, S, Aldington, D, Cole, P, Wiffen, P

“…Amitriptyline should continue to be used as part of the treatment of neuropathic pain or fibromyalgia, but only a minority of patients will achieve satisfactory pain relief. Limited information suggests that failure with one antidepressant does not mean failure with all.It is unlikely that any large randomised trials of amitriptyline will be conducted in specific neuropathic pain conditions or in fibromyalgia to prove efficacy.…”

Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. by Moore, R, Derry, S, Straube, S, Ireson-Paine, J, Wiffen, P

“…Individual patient data analysis in dental pain demonstrated a strong correlation between more rapid reduction of pain intensity over 0-60 min and better pain relief over 0-6h. Rapid initial reduction of pain intensity was also linked with reduced need for remedication. …”

Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults. by Gill, D, Derry, S, Wiffen, P, Moore, R

“…No studies were found in fibromyalgia.Only one study reported one of our primary outcomes (≥ 50% pain relief), while all three reported group means for pain reduction from baseline to endpoint. …”

Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews. by Wiffen, P, Derry, S, Moore, R, Aldington, D, Cole, P, Rice, A, Lunn, M, Hamunen, K, Haanpaa, M, Kalso, E

“…Only a minority of people achieved acceptably good pain relief with either drug, but it is known that quality of life and function improved markedly with the outcome of at least 50% pain intensity reduction. …”

Opioids for cancer pain - an overview of Cochrane reviews. by Wiffen, P, Wee, B, Derry, S, Bell, R, Moore, R

“…Typically the reviews titrated dose to effect, a balance between pain relief and adverse events. Various routes of administration of opioids were considered in the reviews; oral with most opioids, but transdermal administration with fentanyl, and buprenorphine. …”