Palladium-catalyzed aminosulfonylation of aryl halides. by Nguyen, B, Emmett, E, Willis, M

Palladium-catalysed addition of aryl halides to N-sulfinylamines for the synthesis of sulfinamides by Wei, M-K, Moseley, D, Bär, R, Sempere, Y, Willis, M

“…Herein, we report the synthesis of sulfinamides from aryl and alkenyl (pseudo) halides and N-sulfinylamines, enabled by palladium catalysis. …”

Palladium- and Copper-Catalyzed Aryl Halide Amination, Etherification and Thioetherification Reactions in the Synthesis of Aromatic Heterocycles by Sadig, J, Willis, M

“…This article reviews the use of palladium- and copper-catalyzed aryl halide amination, etherification and thioetherification processes in the synthesis of heteroaromatic molecules. …”

One-pot three-component sulfone synthesis exploiting palladium-catalysed aryl halide aminosulfonylation by Richards-Taylor, C, Blakemore, D, Willis, M

“…The sulfinate is combined, in situ, with an electrophilic coupling partner, such as a benzylic, allylic or alkyl halide, an electron-poor arene, or a cyclic epoxide, to provide the corresponding sulfone products in good to excellent yields. …”

Palladium-catalyzed coupling of ammonia and hydroxide with aryl halides: the direct synthesis of primary anilines and phenols. by Willis, M

“…The use of specific sterically demanding electron-rich phosphine ligands makes it possible for ammonia and potassium hydroxide to act as coupling partners in palladium-catalyzed coupling with aryl halides. © 2007 Wiley-VCH Verlag GmbH and. Co. KGaA.…”

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides by Markovic, T, Rocke, B, Blakemore, D, Mascitti, V, Willis, M

Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides. by Emmett, E, Richards-Taylor, C, Nguyen, B, Garcia-Rubia, A, Hayter, B, Willis, M

“…By using DABCO·(SO(2))(2), DABSO, as a solid bench-stable SO(2)-equivalent, the palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides has been achieved. N,N-Dialkylhydrazines are employed as the N-nucleophiles and provide N-aminosulfonamides as the products in good to excellent yields. …”

Palladium-catalyzed aryl halide carbonylation-intramolecular O-enolate acylation: efficient isocoumarin synthesis, including the synthesis of thunberginol A. by Tadd, A, Fielding, MR, Willis, M

Palladium-catalyzed synthesis of ammonium sulfinates from aryl halides and a sulfur dioxide surrogate: a gas- and reductant-free process. by Emmett, E, Hayter, B, Willis, M

“…Described herein is a simple reaction system consisting of the sulfur dioxide surrogate DABSO, triethylamine, and a palladium(0) catalyst for effective convertion of a broad range of aryl and heteroaryl halides into the corresponding ammonium sulfinates. …”

2-(2-haloalkenyl)-aryl halides as substrates for palladium-catalysed tandem C-N bond formation: Efficient synthesis of 1-substituted indoles by Willis, M, Brace, G, Findlay, T, Holmes, I

“…2-(2-Haloalkenyl)-aryl halides, conveniently prepared in a single step from the corresponding o-halobenzaldehydes, are combined with amines under Pd catalysis to provide 1-substituted indoles. …”

Palladium- and copper-catalysed heterocycle synthesis by Ball, C

“…<p>A number of privileged starting materials based on aryl halide frameworks have emerged that allow access to a variety of different heterocyclic scaffolds through judicious choice of reaction conditions. …”

Reductant-free cross-electrophile synthesis of di(hetero)arylmethanes by palladium-catalyzed desulfinative C–C coupling by McKnight, J, Shavnya, A, Sach, NW, Blakemore, DC, Moses, IB, Willis, M

“…The method is reductant-free, and involves a sulfinate transfer reagent and a Pd-catalyst mediating the union of two electrophilic coupling partners; a (hetero)aryl halide and a benzyl halide. We establish for the first time that benzyl sulfinates, generated in situ, undergo efficient Pd-catalyzed desulfinative cross-coupling with (hetero)aryl halides to generate di(hetero)arylmethanes. …”

Development of catalytic methods to exploit sulfur dioxide in organic synthesis by Emmett, EJ

“…This <em>in situ</em> derived sulfinate is coupled with an (hetero)aryl or alkenyl (pseudo)halide using palladium catalysis to form the desired sulfone. …”

Tandem copper-catalysed aryl and alkenyl amination reactions: the synthesis of N-functionalised indoles. by Hodgkinson, R, Schulz, J, Willis, M

“…A Cu-diamine complex effectively catalyses tandem C-N bond formation on 2-(2-haloalkenyl)-aryl halide substrates, to deliver a series of N-functionalised indoles. …”

Palladium-catalyzed alpha-arylation of oxindoles. by Durbin, M, Willis, M

“…Significant variation of the substitution pattern on both the oxindole and aryl halide is possible.…”

Cascade palladium-catalyzed alkenyl aminocarbonylation/ intramolecular aryl amidation: an annulative synthesis of 2-quinolones. by Tadd, A, Matsuno, A, Fielding, MR, Willis, M

“…Palladium-catalyzed intermolecular aminocarbonylation/intramolecular amidation cascade sequences can be used to convert a range of 2-(2-haloalkenyl)aryl halide substrates efficiently and selectively to the corresponding 2-quinolones. …”

Heterocyclic allylsulfones as latent heteroaryl nucleophiles in palladium-catalyzed cross-coupling reactions by Markovic, T, Murray, P, Rocke, B, Shavnya, A, Blakemore, D, Willis, M

“…Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. …”

Chelating phosphane-boranes as hemilabile ligands - Synthesis of [Mn(CO)3(eta(2)-H3B center dot dppm)][BAr4F] and [Mn(CO)(4)(eta(1)-H3B center dot dppm)][BAr4F] by Merle, N, Frost, C, Kociok-Koehn, G, Willis, M, Weller, A

“…Addition of H3B·dppm to Mn(CO)5Br using Na[BArF4] as a halide-abstracting reagent affords [Mn(CO)3(η2-H3B·dppm)][BAr F4] (1). …”

Novel S-based chemotypes of tunable reactivity for applications in chemical biology by Bell, C

“…These approaches include the development of sulfonimidoyl halides as chiral intermediates, bifunctional reagents and electrophilic warheads, and the application of alternative S(IV) nucleophiles in cross-coupling transformations.…”

DABSO-based, three-component, one-pot sulfone synthesis. by Deeming, A, Russell, C, Hennessy, A, Willis, M

“…The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums.…”