SYNTHESIS AND EFFECTS ON HUMAN LIVER GLYCOSIDASES OF 6-DEOXY-DMDP by Hughes, D, Fleet, G, Molyneaux, R, Winchester, B

SYNTHESIS AND EFFECTS ON HUMAN LIVER GLYCOSIDASES OF SOME 6-DEOXYDMDP ANALOGS by Beacham, A, Fleet, G, Biggadike, K, Winchester, B

Effect on human liver glycosidases and short syntheses of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine from D-glycero-D-gulo-heptono-1,4-lactone. by Collin, W, Fleet, G, Haraldsson, M, Cenci di Bello, I, Winchester, B

“…The effects of 1 on the inhibition of 15 human liver glycosidases are described.…”

Inhibition of alpha-L-fucosidase by derivatives of deoxyfuconojirimycin and deoxymannojirimycin. by Winchester, B, Barker, C, Baines, S, Jacob, G, Namgoong, S, Fleet, G

“…Deoxyfuconojirimycin (1,5-dideoxy-1,5-imino-L-fucitol) is a potent, specific and competitive inhibitor (Ki 1 x 10(-8) M) of human liver alpha-L-fucosidase (EC 3.2.1.51). Six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha-L-fucosidase and other human liver glycosidases. …”

TETRAZOLES OF MANNO-PYRANOSES AND RHAMNO-PYRANOSES - INHIBITION OF GLYCOSIDASES BY TETRAZOLES AND OTHER MANNOSE MIMICS by Brandstetter, T, Davis, B, Hyett, D, Smith, C, Hackett, L, Winchester, B, Fleet, G

“…These and other materials are assessed as inhibitors of human liver glycosidases and delineate some structural features required for α- and β-mannosidase and α-fucosidase inhibition. © 1995.…”

SYNTHESIS OF, AND LACK OF INHIBITION OF A RHAMNOSIDASE BY, BOTH ENANTIOMERS OF DEOXYRHAMNOJIRIMYCIN AND RHAMNONOLACTAM - BETA-MANNOSIDASE INHIBITION BY DELTA-LACTAMS by Fairbanks, A, Carpenter, N, Fleet, G, Ramsden, N, Debello, I, Winchester, B, Aldaher, S, Nagahashi, G

“…The effects as inhibitors of the enantiomeric deoxyrhamnojirimycins and rhamnonolactams on human liver glycosidases are compared with deoxymannojirimycin and mannonolactam. …”

INHIBITION OF ALPHA-MANNOSIDASES BY 7 CARBON SUGARS - SYNTHESIS OF SOME 7 CARBON ANALOGS OF MANNOFURANOSE by Myerscough, P, Fairbanks, A, Jones, A, Bruce, I, Choi, S, Fleet, G, Aldaher, S, Dibello, I, Winchester, B

“…The effects on human liver glycosidases of some seven carbon analogues of mannopyranose and mannofuranose are compared with those of deoxymannojirimycin and DIM. …”

SYNTHESIS OF CYCLOPENTANE SPIROHYDANTOINS BY ALDOL CYCLIZATIONS - AN APPROACH TO HIGHLY SUBSTITUTED ALPHA-CYCLOPENTANE AMINO-ACIDS by Fairbanks, A, Elliott, R, Smith, C, Hui, A, Way, G, Storer, R, Taylor, H, Watkin, D, Winchester, B, Fleet, G

“…The effects of some of the compounds on human liver-glycosidases are described. © 1993.…”

SYNTHESIS FROM D-MANNOSE OF 1,4-DIDEOXY-1,4-IMINO-L-RIBITOL AND OF THE ALPHA-MANNOSIDASE INHIBITOR 1,4-DIDEOXY-1,4-IMINO-D-TALITOL by Fleet, G, Son, J, Green, D, Dibello, I, Winchester, B

“…The syntheses of 1,4-dideoxy-l,4-imino-L-ribitol and of 1,4-dideoxy-l,4-imino-D-talitol from D-mannose are described. 1,4-Dideoxy-l,4-imino-D-talitol is a specific and competitive inhibitor of human liver α-mannosidase in vitro and also blocks the lysosomal catabolism of asparigine-linked glycans of glycoproteins in vivo. © 1988.…”

Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone. by Fleet, G, Ramsden, N, Nash, R, Fellows, L, Jacob, G, Molyneux, R, di Bello, I, Winchester, B

“…The inhibitory activities of the diastereomers against the amyloglucosidase-catalysed hydrolysis of p-nitrophenyl alpha-D-glucopyranoside were investigated, and the effects of 6-epicastanospermine and of 1,6-diepicastanospermine on 14 human liver glycosidases are reported.…”

Change in specificity of glycosidase inhibition by N-alkylation of amino sugars. by al Daher, S, Fleet, G, Namgoong, S, Winchester, B

“…The synthetic amino sugar 1,4-dideoxy-1,4-imino-L-allitol (DIA) is a moderately good inhibitor of human liver alpha-D-mannosidases and a weak inhibitor of alpha-L-fucosidase, N-acetyl-beta-D-hexosaminidase and beta-D-mannosidase. …”

The structural basis of the inhibition of human alpha-mannosidases by azafuranose analogues of mannose. by Winchester, B, al Daher, S, Carpenter, N, Cenci di Bello, I, Choi, S, Fairbanks, A, Fleet, G

“…Eight pyrrolidine, five pyrrolizidine and one indolizidine analogue(s) of the known alpha-mannosidase inhibitor, the azafuranose, 1,4-dideoxy-1,4-imino-D-mannitol (DIM), have been tested for inhibition of the multiple forms of alpha-mannosidase in human liver in vitro. Substitution of the ring nitrogen markedly decreased or abolished inhibition, but loss of the C-6 hydroxy group, as in 6-deoxy-DIM and 6-deoxy-6-fluoro-DIM, enhanced inhibition, particularly of the lysosomal alpha-mannosidase. …”