Physiological noise modelling for spinal functional magnetic resonance imaging studies. by Brooks, J, Beckmann, C, Miller, K, Wise, R, Porro, C, Tracey, I, Jenkinson, M

Brainstem functional magnetic resonance imaging: disentangling signal from physiological noise. by Harvey, A, Pattinson, K, Brooks, J, Mayhew, S, Jenkinson, M, Wise, R

“…PURPOSE: To estimate the importance of respiratory and cardiac effects on signal variability found in functional magnetic resonance imaging data recorded from the brainstem. …”

A functional magnetic resonance imaging study into lateralisation of nociceptive processing in the human brain by Youell, P, Wise, R, El-Badry, M, King, T, Dickinson, MR, Tracey, I, Jones, A

An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. by Rogers, R, Wise, R, Painter, D, Longe, SE, Tracey, I

“… BACKGROUND: Anatomic sites within the brain, which activate in response to noxious stimuli, can be identified with the use of functional magnetic resonance imaging. The aim of this study was to determine whether the analgesic effects of ketamine could be imaged. …”

Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. by Youell, P, Wise, R, Bentley, D, Dickinson, MR, King, T, Tracey, I, Jones, A

“…The resultant brain activity was measured using 3-T functional magnetic resonance imaging, by determining significant changes in blood oxygen level dependent (BOLD) signal and applying a general linear modelling approach. …”

A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. by Zambreanu, L, Wise, R, Brooks, J, Iannetti, G, Tracey, I

“…To fully characterise the supraspinal contributions to central sensitisation in humans, we used whole-brain functional magnetic resonance imaging at 3T, to record brain responses to punctate mechanical stimulation in an area of secondary hyperalgesia. …”

Opioids modulate the brain activity associated with breath holding: an functional magnetic resonance imaging study by Pattinson, K, Governo, R, Macintosh, B, Russell, E, Corfield, DR, Tracey, I, Wise, R

Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. by Wise, R, Pattinson, K, Bulte, D, Chiarelli, P, Mayhew, S, Balanos, G, O'Connor, D, Pragnell, T, Robbins, P, Tracey, I, Jezzard, P

A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. by Dunckley, P, Wise, R, Fairhurst, M, Hobden, P, Aziz, Q, Chang, L, Tracey, I

“…We used functional magnetic resonance imaging to image the neural correlates of visceral and somatic pain within the brainstem. …”

Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans. by Iannetti, G, Niazy, R, Wise, R, Jezzard, P, Brooks, J, Zambreanu, L, Vennart, W, Matthews, P, Tracey, I

“…Simultaneous recording of event-related electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) responses has the potential to provide information on how the human brain reacts to an external stimulus with unique spatial and temporal resolution. …”

Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol. by Mhuircheartaigh, R, Rosenorn-Lanng, D, Wise, R, Jbabdi, S, Rogers, R, Tracey, I

“…We investigated the effects of propofol, widely used for anesthesia and sedation, on spontaneous and evoked cerebral activity using functional magnetic resonance imaging (fMRI). A series of auditory and noxious stimuli was presented to eight healthy volunteers at three behavioral states: awake, "sedated" and "unresponsive." …”

Pharmacological fMRI: A new tool for drug development in humans by Tracey, I, Wise, R

“…The advent of pharmacological functional magnetic resonance imaging (phMRI) has enabled researchers to focus directly on human pharmacology and brain function. …”

Modeling of regional dynamic CO(2) reactivity in respiratory related brain areas using BOLD fMRI by Mitsis, G, Harvey, A, Dirckx, S, Mayhew, S, Rogers, R, Tracey, I, Wise, R, Pattinson, K, IEEE

“…We have used BOLD functional magnetic resonance imaging (fMRI) and externally induced CO2 challenges that stimulate respiration, to identify respiratory areas in-vivo in humans and to quantify the dynamic effects of CO2 on the BOLD fMRI signal (dynamic CO2 reactivity). …”

Using fMRI to quantify the time dependence of remifentanil analgesia in the human brain. by Wise, R, Williams, P, Tracey, I

“…To understand and exploit centrally acting drugs requires reliable measures of their time course of action in the human brain. Functional magnetic resonance imaging (fMRI) is able to measure noninvasively, drug-induced changes in task-related brain activity. …”

Evidence for a vascular contribution to diffusion FMRI at high b value. by Miller, K, Bulte, D, Devlin, H, Robson, M, Wise, R, Woolrich, M, Jezzard, P, Behrens, T

“…Recent work has suggested that diffusion-weighted functional magnetic resonance imaging (FMRI) with strong diffusion weighting (high b value) detects neuronal swelling that is directly related to neuronal firing. …”

Defining a left-lateralized response specific to intelligible speech using fMRI. by Narain, C, Scott, S, Wise, R, Rosen, S, Leff, A, Iversen, S, Matthews, P

“…This study attempted to reconcile these differences, using a more sensitive 3 T functional magnetic resonance imaging system, and a sparse sampling paradigm. …”

Identification of the regional variability of the brain hemodynamic response to spontaneous and step-induced CO 2 changes using function expansions by Prokopiou, P, Pattinson, K, Wise, R, Mitsis, G

“…Here, we examine in detail the regional characteristics of the hemodynamic response to spontaneous and larger, externally induced step CO 2 changes CO 2 (end-tidal forcing) by utilizing BOLD functional magnetic resonance imaging (fMRI) measurements from healthy humans. …”

Exacerbation of pain by anxiety is associated with activity in a hippocampal network. by Ploghaus, A, Narain, C, Beckmann, C, Clare, S, Bantick, S, Wise, R, Matthews, P, Rawlins, J, Tracey, I

“…Using event-related functional magnetic resonance imaging (FMRI), we compared activation responses to noxious thermal stimulation while perceived pain intensity was manipulated by changes in either physical intensity or induced anxiety. …”

The effects of respiratory CO2 fluctuations in the resting-state BOLD signal differ between eyes open and eyes closed. by Peng, T, Niazy, R, Payne, S, Wise, R

“…In this study we focus on the two commonly used resting-states in functional magnetic resonance imaging experiments, eyes open and eyes closed, and quantify the degree to which measured spontaneous fluctuations in the partial pressure of end-tidal CO2 (Petco2) relate to BOLD signal time series. …”

Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration. by Miskowiak, K, Inkster, B, Selvaraj, S, Wise, R, Goodwin, G, Harmer, C

“…Neuronal responses during the processing of happy and fearful faces were investigated using functional magnetic resonance imaging (fMRI); facial expression recognition performance was assessed after the fMRI scan. …”