Targeting FGL2 in glioma immunosuppression and malignant progression by Xiaoyu Ma, Hongtao Zhu, Lidong Cheng, Xin Chen, Kai Shu, Suojun Zhang

“…This review discusses the immunosuppressive role of FGL2 in the GBM tumor microenvironment and its ability to promote malignant tumor progression while considering FGL2-targeted therapeutic strategies. …”
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Editorial: The role of TNF-TNFR2 signal in immunosuppressive cells and its therapeutic implications, volume II by Xin Chen, Magdalena Plebanski

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Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment by Qin Ding, Fengjie Lin, Zongwei Huang, Ying Li, Sunqin Cai, Xin Chen, Hui Liu, Sufang Qiu

“…According to the present study, non-coding RNA-related low levels of FCGBP are a prognostic indicator and are linked to an HNSC-related immunosuppressive state.…”
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HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression by Xin Chen, Xiaodong Wang, Feng Zhu, Chao Qian, Fanggui Xu, Xin Huang, Wenjie Zhang, Beicheng Sun

“…PDZK1 is an HBV infection-related gene, which plays oncogenic roles, possibly due to enhancing PI3K-Akt, fatty acid usage in tumor cells and TAMs, and Treg-induced immunosuppression.…”
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ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis by Yuan Lin, Ying Zhang, Zhouting Tuo, Liang Gao, Demao Ding, Liangkuan Bi, Dexin Yu, Zhengmei Lv, Jiani Wang, Xin Chen

“…Furthermore, in most tumor types, immunosuppression-related genes, especially TGFBR1 and PD-L1 (CD274), exhibited a specific correlation with the expression of ORC6. …”
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Antitumour mechanisms of traditional Chinese medicine elicited by regulating tumour-associated macrophages in solid tumour microenvironments by Jiamin Gao, Weishan Tan, Luyun Yuan, Haoyue Wang, Junkai Wen, Kexiang Sun, Xin Chen, Shuyun Wang, Wanli Deng

“…TCM has unique advantages in improving the solid tumour microenvironment, particularly in regulating TAMs to further inhibit tumour angiogenesis, reduce drug resistance, reverse immunosuppression, and enhance antitumour immunity. This review highlights the TAM-associated mechanisms within the solid tumour microenvironment, outlines the recent advancements in TCM targeting TAMs for antitumour effects, emphasises the superiority of combining TCM with standard treatments or new nano-drug delivery systems, and evaluates the safety and efficacy of TCM combined with conventional treatments via clinical trials to provide insights and strategies for future research and clinical treatment.…”
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Dynamic Monitoring of CD200 Mediated by Ascites-Derived Exosomes as a Predictor of Survival and Response to Front-Line Chemotherapeutics in Advanced High-Grade Serous Ovarian Cance... by Ying Ji, Shanshan Liu, Genju Wang, Xin Chen, Yujuan Li, Xiaogai Zhi, Hongxiu Jiang, Juan Tang, Yi Ding, Shuli Zhao, Hongmei Zhou, Aiwei Xiong

“…CD200, an immune checkpoint, has been engineered to affect immunosuppression in ovarian cancer. However, the potential of CD200 to serve as a predictor of ovarian cancers remains unexplored. …”
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The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review by Suhana Ahmad, Nor Azrini Azid, Jennifer C. Boer, JitKang Lim, Xin Chen, Magdalena Plebanski, Rohimah Mohamud, Rohimah Mohamud

“…However, recent studies reveal anti-intuitive effects of TNF in the activation and proliferative expansion of immunosuppressive Tregs, tolerogenic DCs and MDSCs. This immunosuppressive effect of TNF is mediated by TNFR2, which is preferentially expressed by immunosuppressive cells. …”
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USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer by Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song, Wenting Liao

“…IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer.…”
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A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients by Ling Pei, Run Li, Hong Zhou, Wenxin Du, Yajie Gu, Yingshuo Jiang, Yongqing Wang, Xin Chen, Jianguo Sun, Junrong Zhu

“…Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. …”
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Therapeutic potential of TNFR2 agonists: a mechanistic perspective by Yibo Chen, Mengmeng Jiang, Xin Chen, Xin Chen, Xin Chen, Xin Chen

“…TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs). …”
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Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy by Zhiqi Zhang, Xiaoxuan Xu, Jiawei Du, Xin Chen, Yonger Xue, Jianqiong Zhang, Xue Yang, Xiaoyuan Chen, Jinbing Xie, Shenghong Ju

“…Abstract Immunotherapy with immune checkpoint blockade (ICB) for glioblastoma (GBM) is promising but its clinical efficacy is seriously challenged by the blood-tumor barrier (BTB) and immunosuppressive tumor microenvironment. Here, anti-programmed death-ligand 1 antibodies (aPD-L1) are loaded into a redox-responsive micelle and the ICB efficacy is further amplified by paclitaxel (PTX)-induced immunogenic cell death (ICD) via a co-encapsulation approach for the reinvigoration of local anti-GBM immune responses. …”
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Molecular profiling identifies distinct subtypes across TP53 mutant tumors by Xin Chen, Tianqi Liu, Jianqi Wu, Chen Zhu, Gefei Guan, Cunyi Zou, Qing Guo, Xiaolin Ren, Chen Li, Peng Cheng, Wen Cheng, Anhua Wu

“…Among the 5 subtypes, COCA3 was identified as the subtype with worst prognosis, causing an immunosuppressive microenvironment and immunotherapeutic resistance. …”
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TNFR2 expression predicts the responses to immune checkpoint inhibitor treatments by Ping Liao, Mengmeng Jiang, Md Sahidul Islam, Yiru Wang, Xin Chen, Xin Chen, Xin Chen, Xin Chen

“…TNFR2 is highly expressed by the maximally immunosuppressive subset of CD4+Foxp3+ regulatory T cells (Tregs), especially those present in tumor microenvironment (TME). …”
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Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma by Tahereh Setayesh, Ying Hu, Farzam Vaziri, Xin Chen, Jinping Lai, Dongguang Wei, Yu-Jui Yvonne Wan

“…This study examines inhibiting galectin 1 (Gal1) as a treatment option for hepatocellular carcinoma (HCC). Gal1 has immunosuppressive and cancer-promoting roles. Our data showed that Gal1 was highly expressed in human and mouse HCC. …”
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Exosome-Modified Liposomes Targeted Delivery of Thalidomide to Regulate Treg Cells for Antitumor Immunotherapy by Yang Yang, Qingfu Wang, Huimin Zou, Chon-Kit Chou, Xin Chen

“…Our group found that thalidomide can suppress the regulatory T cells (Tregs), a minor subset of CD4⁺ T cells (~10%) with unique immunosuppressive activity that have been shown to accumulate in the tumor microenvironment (TME) and represent a major mechanism of tumor immune evasion. …”
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Treatment of refractory lupus nephritis using leflunomide: A prospective study by Shuo Zhang, Shuo Zhang, Yiran Chen, Xin Chen, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Li Wang, Mengtao Li

“…A daily dose of 20–40 mg of leflunomide was given to the patients orally. Meanwhile, immunosuppressives were withdrawn, and corticosteroids were gradually tapered. …”
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Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest by Tao Yan, He Yang, Caixia Xu, Junsi Liu, Yun Meng, Qing Jiang, Jinxing Li, Guiqiong Kang, Liangjian Zhou, Shuai Xiao, Yanpeng Xue, Jiayi Xu, Xin Chen, Fengyuan Che

“…In glioma, abnormal HA biosynthesis is intimately involved in glioma malignant biological properties and the formation of immunosuppressive microenvironment; however, the role of abnormal HA catabolism in glioma remains unclear. …”
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Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia by Wenwen Guo, Xin Liu, Mingyang Wang, Jia Liu, Yigeng Cao, Yawei Zheng, Weihua Zhai, Xin Chen, Rongli Zhang, Qiaoling Ma, Donglin Yang, Jialin Wei, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Erlie Jiang

“…ABSTRACTObjectives To determine the impact of pretransplant measurable residual disease (pre-MRD) and the efficacy of maintenance therapy in t(8;21) acute myeloid leukemia (AML) patients after allogeneic hematopoietic cell transplantation (allo-HCT).Methods We retrospectively analyzed 100 t(8;21) AML patients who underwent allo-HCT between 2013 and 2022. 40 patients received pre-emptive therapy including immunosuppressant adjustment, azacitidine, and donor lymphocyte infusion (DLI) combined with chemotherapy. 23 patients received prophylactic therapy, including azacitidine or chidamide.Results Patients with a positive pre-MRD (pre-MRDpos) had a higher 3-year cumulative incidence of relapse (CIR) (25.90% [95% CI, 13.87%–39.70%] vs 5.00% [95% CI, 0.88%–15.01%]; P = 0.008). …”
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Prognosis and Immunological Characteristics of PGK1 in Lung Adenocarcinoma: A Systematic Analysis by Yuechao Yang, Huanhuan Cui, Deheng Li, Yang Gao, Lei Chen, Changshuai Zhou, Mingtao Feng, Wenjing Tu, Sen Li, Xin Chen, Bin Hao, Liangdong Li, Yiqun Cao

“…More importantly, PGK1 was highly expressed in immunosuppressive cells, including M2 macrophages, Tregs, and exhausted T cells, among others. …”
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