A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop by Zuoxiang Xiao, Gongping Shi, Sichuan Xi, Amit Kumar Singh, Jami Willette-Brown, Xin Li, Feng Zhu, Ling Su, Xiaolin Wu, David S. Schrump, Yinling Hu

“…Here, we observed high expression of TNFR1 in many human lung squamous cell carcinoma (SCCs) samples and in spontaneous lung SCCs derived from kinase-dead Ikkα knock-in (KA/KA) mice. Knocking out Tnfrf1a in KA/KA mice blocked lung SCC formation. …”
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YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway by Xin Li, Xin Li, Tian-Kui Ma, Min Wang, Xiao-Dan Zhang, Tian-Yan Liu, Yue Liu, Zhao-Hui Huang, Yong-Hong Zhu, Shuang Zhang, Li Yin, Yan-Yan Xu, Hong Ding, Cong Liu, Hang Shi, Qiu-Ling Fan, Qiu-Ling Fan

“…The aim of this work was to dissect a novel regulatory mechanism of Yin and Yang 1 (YY1) on lncRNA-ARAP1-AS2/ARAP1 to regulate EGFR/PKM2/HIF-1α pathway and glycolysis in DKD.Materials and methods: We used adeno-associated virus (AAV)-ARAP1 shRNA to knocked down ARAP1 in diabetic mice and overexpressed or knocked down YY1, ARAP1-AS2 and ARAP1 expression in human glomerular mesangial cells. …”
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The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice by Kazufumi Matsushita, Xin Li, Yuki Nakamura, Danyue Dong, Kaori Mukai, Mindy Tsai, Stephen B. Montgomery, Stephen J. Galli

“…Quantitative trait locus analysis and RNA sequencing of BM-derived cultured MCs (BMCMCs) from CC027 mice suggested Sp140 as a candidate gene for MC activation. siRNA-mediated knock-down of Sp140 in BMCMCs decreased IgE-dependent histamine release and cytokine production. …”
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Genetic Engineering of <i>Klebsiella pneumoniae</i> ATCC 25955 for Bioconjugate Vaccine Applications by Yan Liu, Shulei Li, Yan Guo, Xin Li, Li Zhu, Hengliang Wang, Jun Wu, Chao Pan

“…Furthermore, two genes (<i>wbbY</i> and <i>wbbZ</i>) located in the O-antigen biosynthesis gene cluster were knocked out to change the O1 serotype of the engineered strain into the O2 serotype. …”
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High Production of Nattokinase via Fed-Batch Fermentation of the γ-PGA-Deficient Strain of <i>Bacillus licheniformis</i> by Xin Li, Jing Yang, Jun Liu, Xiaohui Zhang, Wei Wu, Dazhong Yan, Lihong Miao, Dongbo Cai, Xin Ma, Shouwen Chen

“…The impact of γ-PGA synthesis on NK production remains unclear. In this study, we knocked out the <i>pgsC</i> gene, a component of the γ-PGA synthetase cluster (<i>pgsBCA</i>), and constructed a novel recombinant strain, <i>Bacillus licheniformis</i> BL11. …”
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RETRACTED: AnnexinA5 Might Suppress the Phenotype of Human Gastric Cancer Cells via ERK Pathway by Xiaojie Wang, Yarui Dai, Yina Zhao, Meichuan Li, Jialu Zhang, Yunzhe Ci, Huan Wang, Xin Li

“…To further detect the mechanism of annexinA5 action, the signal pathway was examined with Western Blot method. When ANXA5 gene was knocked down, cell proliferation and metastasis were promoted, while cell apoptosis was suppressed. …”
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Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study by Lei Chen, Tong Yu, Yiman Zhai, Hongguang Nie, Xin Li, Yan Ding

“…Experimental data by knocking down STAT3 proved that Lut could reduce the phosphorylation of JAK/STAT and enhance the level of SOCS3, which abrogated the inhibition of ENaC expression induced by LPS accordingly. …”
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Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (<i>TrkA</i>) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization by InSug O-Sullivan, Ranjan Kc, Gurjit Singh, Vaskar Das, Kaige Ma, Xin Li, Fackson Mwale, Gina Votta-Velis, Benjamin Bruce, Arivarasu Natarajan Anbazhagan, Andre J. van Wijnen, Hee-Jeong Im

“…OA-associated joint pain was markedly improved without cartilage protection in sensory-neuron-specific conditional <i>TrkA</i> knock-out (cKO) mice. Alleviated hyperalgesia was associated with suppression of the NGF/TrkA pathway and reduced angiogenesis in fibroblast-like synovial cells. …”
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Proteomic Studies on the Mechanism of Myostatin Regulating Cattle Skeletal Muscle Development by Hui Sheng, Yiwen Guo, Linlin Zhang, Junxing Zhang, Manning Miao, Haoyun Tan, Debao Hu, Xin Li, Xiangbin Ding, Guangpeng Li, Hong Guo

“…At the same time, Co-Immunoprecipitation (CO-IP) assay showed that MSTN gene interacted with extracellular matrix related protein type I collagen α 1 (COL1A1), and knocking down the expression of COL1A1 could inhibit the activity of adhesion, PI3K-AKT and ribosome pathway, thus inhibit BSMSCs proliferation. …”
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Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs by Amal Abdelmawla, Amal Abdelmawla, Chen Yang, Xin Li, Mang Li, Chang Long Li, Yi Bo Liu, Xu Jiang He, Xu Jiang He, Zhi Jiang Zeng, Zhi Jiang Zeng

“…No circRNAs were enriched into these key pathways. Knocking down two key genes (KMO and TPH1) resulted in altered body color, suggesting that feeding NQ’s an RNAi-based diet significantly downregulated the expression of TPH1 and KMO in 4-day-old larvae, which confirmed the function of key DEGs in the regulation of honeybee body color.Conclusion: These findings reveal that the larval diets from A. mellifera could change the body color of A. cerana, perhaps by altering the expression of non-coding RNAs and related key genes. …”
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A combination of genomics and transcriptomics provides insights into the distribution and differential mRNA expression of type VI secretion system in clinical Klebsiella pneumoniae by Wanzhen Li, Xiaolan Huang, Dan Li, Xiaofen Liu, Xiaoying Jiang, Xingchen Bian, Xin Li, Jing Zhang

“…Afterward, we utilized the predominant sequence type 11 (ST11) K. pneumoniae HS11286 to investigate the effect of knocking out T6SS marker genes hcp or vgrG. Transcriptome analysis identified a total of 1,298 co-upregulated and 1,752 co-downregulated differentially expressed genes in both mutants. …”
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