Hydrogen Sulfide Inhibits Inflammatory Pain and Enhances the Analgesic Properties of Delta Opioid Receptors by Aina Porta, Laura Rodríguez, Xue Bai, Gerard Batallé, Gerard Roch, Enric Pouso-Vázquez, Gianfranco Balboni, Olga Pol

“…Several treatments potentiate the analgesic actions of δ-opioid receptor (DOR) agonists, but the role of H₂S in modulating their effects and expression during inflammatory pain remains untested. …”
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Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated by Xue Bai, Gerard Batallé, Gianfranco Balboni, Olga Pol

“…Recent studies have revealed that hydrogen sulfide (H₂S) increases the analgesic actions of the δ-opioid receptor (DOR) in inflammatory pain. …”
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Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice by Santiago Coral-Pérez, Ignacio Martínez-Martel, Maria Martínez-Serrat, Gerard Batallé, Xue Bai, Christie R. A. Leite-Panissi, Olga Pol

“…These data revealed the analgesic, antidepressant, and anxiolytic actions of HRW. …”
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Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain by Xue Bai, Gerard Batallé, Ignacio Martínez-Martel, Olga Pol

“…Data showed that the analgesic effects of JWH-133, systemically and locally administered, were improved by the DADS or GYY4137 pretreatment. …”
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The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide by Gerard Batallé, Xue Bai, Gianfranco Balboni, Olga Pol

“…Moreover, the increased expression of DOR triggered by H₂S might support the improved analgesic actions of UFP-512 co-administered with H₂S donors. …”
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The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain by Xue Bai, Gerard Batallé, Olga Pol

“…This study provides evidence of the anxiolytic and antidepressant properties of DADS and GYY4137 during neuropathic pain and reveals their analgesic actions, suggesting that these therapeutic properties may result from the inhibition of the inflammatory, apoptotic, and oxidative responses in the AMG and/or PAG. …”
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The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice by Gerard Batallé, Xue Bai, Olga Pol

“…The Nrf2 pathway is implicated in the analgesic actions of DADS and GYY4137 during joint degeneration. …”
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Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice by Maria Martínez-Serrat, Ignacio Martínez-Martel, Santiago Coral-Pérez, Xue Bai, Gerard Batallé, Olga Pol

“…The likely pathways implied in the HRW analgesic activity, as well as the interaction between heme oxygenase 1 (HO-1) enzyme and H₂ during neuropathic pain were also studied. …”
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The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated by Irene Suárez-Rojas, Montse Pérez-Fernández, Xue Bai, Ignacio Martínez-Martel, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Olga Pol

“…Then, using male mice with neuropathic pain provoked by chronic constriction of the sciatic nerve (CCI), we analyzed and compared the analgesic actions produced by three new heme oxygenase 1 (HO-1) inducers, 1m, 1b, and 1a, with those performed by dimethyl fumarate (DMF). …”
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Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway by Montse Pérez-Fernández, Irene Suárez-Rojas, Xue Bai, Ignacio Martínez-Martel, Valeria Ciaffaglione, Valeria Pittalà, Loredana Salerno, Olga Pol

“…Recent reports demonstrate that the induction of heme oxygenase-1 (HO-1) enzyme produces analgesic effects in animals with osteoarthritis pain and reverses the grip strength loss caused by sciatic nerve crush. …”
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The Recovery of Cognitive and Affective Deficiencies Linked with Chronic Osteoarthritis Pain and Implicated Pathways by Slow-Releasing Hydrogen Sulfide Treatment by Gerard Batallé, Xue Bai, Enric Pouso-Vázquez, Gerard Roch, Laura Rodríguez, Olga Pol

“…The anti-inflammatory, analgesic, and antidepressant effects of slow-releasing hydrogen sulfide (H₂S) donors during osteoarthritic pain have been shown, but their actions in the accompanying memory impairment and anxious-like behaviors have not yet been demonstrated. …”
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