S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma by Chengming Liu, Sufei Zheng, Zhiliang Lu, Zhanyu Wang, Sihui Wang, Xiaoli Feng, Yan Wang, Nan Sun, Jie He

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Single-cell RNA sequencing reveals that the immunosuppression landscape induced by chronic stress promotes colorectal cancer metastasis by Yingru Zhang, Ying Feng, Yiyang Zhao, Yuanyuan Feng, Mengyao Li, Wenkai Wang, Zhongya Ni, Huirong Zhu, Yan Wang

“…Using 10✕Genomics single-cell transcriptome sequencing technology, we profiled nearly 30,000 cells from tumour samples of 8 mice from the control and CUMS groups, revealed that immune cells in tumours under a chronic stress state trend toward a more immunosuppressive and exhaustive status, and described the crosstalk between the overall inflammatory environment and immunosuppressive landscape to provide mechanistic information or efficacious strategies for immune-oncology treatments in CRC with depressive disorders.…”
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MAGE‐C3 promotes cancer metastasis by inducing epithelial‐mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma by Qingnan Wu, Weimin Zhang, Yan Wang, Qingjie Min, Hongyue Zhang, Dezuo Dong, Qimin Zhan

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RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer by Yan Wang, Yiwen Mao, Caizhi Wang, Xuefeng Jiang, Qionglan Tang, Lingling Wang, Jialei Zhu, Mengqiu Zhao

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Establishment and application of a rapid diagnostic method for BVDV and IBRV using recombinase polymerase amplification-lateral flow device by Yan Wang, Jinyuan Shang, Zhijie Li, Ao Zhang, Yuening Cheng

“…They both can cause persistent infection and immunosuppression, resulting in significant economic losses in the livestock industry. …”
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T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes by Huadong Yin, Shunshun Han, Yuqi Chen, Yan Wang, Diyan Li, Qing Zhu

“…T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis. Previous study has proven that T-2 toxin caused hepatotoxicity in chicken, but the regulatory mechanism is unclear. …”
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The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective by Xueqing Hu, Xueqing Hu, Yingru Zhang, Yingru Zhang, Hao Yu, Yiyang Zhao, Yiyang Zhao, Xiaoting Sun, Xiaoting Sun, Qi Li, Qi Li, Yan Wang, Yan Wang

“…YAP1 may promote tumor progression through immunosuppression, particularly by suppressing the infiltration of CD8+ T lymphocytes, CD4+ Th1 cells, T follicular helper cells, NKT cells, and activated NK cells, as well as recruiting MDSCs and CAFs in pan-cancer. …”
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Differences in peripheral and central metabolites and gut microbiome of laying hens with different feather-pecking phenotypes by Chao Wang, Yaling Li, Haoliang Wang, Miao Li, Jinsheng Rong, Xindi Liao, Xindi Liao, Xindi Liao, Yinbao Wu, Yinbao Wu, Yinbao Wu, Yan Wang, Yan Wang, Yan Wang

“…Compared to neutrals (N), peckers (P) exhibited the stress-induced immunosuppression with the increased plasma levels of corticosterone and norepinephrine, and the decreased plasma levels of IgA, IL-1, IL-6 and tumor necrosis factor α (p < 0.05). …”
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First‐line immunotherapy or angiogenesis inhibitor combined with chemotherapy for advanced non‐small cell lung cancer with EGFR exon 20 insertions: Real‐world evidence from China... by Guangjian Yang, Yaning Yang, Runze Liu, Weihua Li, Haiyan Xu, Xuezhi Hao, Junling Li, Shuyang Zhang, Fei Xu, Siyu Lei, Yan Wang

“…Activation of PI3K/AKT signaling might mediate intrinsic immunosuppression in NSCLC with EGFR ex20ins.…”
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KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer by Chengming Liu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Xinfeng Wang, Lu Yang, Haiyan Xu, Zheng Cao, Xiaoli Feng, Qi Xue, Yan Wang, Nan Sun, Jie He

“…Conclusions Our study elucidated the molecular mechanism by which KRAS‐G12D mutation drives immunosuppression and enhances resistance of ICIs in NSCLC. …”
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Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface by Jun Liu, Yan Deng, An Wang, Bowen Liu, Xi Zhou, Tailang Yin, Yan Wang, Tao Tang, Yang Qiu, Jiao Chen, Jing Yang

“…Normal pregnancy is maintained due to the immunosuppressed state, but pyroptosis induced by MITA can trigger the body’s immune response and disrupt the immunosuppressed state of the maternal-fetal interface, leading to abortion. …”
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Increased Frequency of Myeloid-Derived Suppressor Cells in Myasthenia Gravis After Immunotherapy by Yan Wang, Chong Yan, Chong Yan, Caixia Su, Ying Wang, Sushan Luo, Sushan Luo, Jun Lu, Jun Lu, Chongbo Zhao, Chongbo Zhao, Gan Zhao, Jianying Xi, Jianying Xi

“…MDSCs from untreated patients with MG showed an impaired suppression of IFN-γ production in T-cells and improved immunosuppressive function was identified after immunotherapy. …”
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Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression by Yan Wang, Bing Liu, Qingjie Min, Xin Yang, Shi Yan, Yuanyuan Ma, Shaolei Li, Jiawen Fan, Yaqi Wang, Bin Dong, Huajing Teng, Dongmei Lin, Qimin Zhan, Nan Wu

“…Additionally, our results show that macrophages are the most abundant cell type in LUAD, and identify different tumor-associated macrophage subpopulations that are unique to each histologic subtype, which might contribute to an immunosuppressive microenvironment. Our results provide a systematic landscape of molecular profiles that drive LUAD subtype progression, and demonstrate potentially novel therapeutic strategies and targets for invasive lung adenocarcinoma.…”
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Case report: Wallerian degeneration: The innate-immune response to adult-onset Still's disease peripheral nerve injury by Hao Cheng, He Lv, Yan Wang, Gui-Qiang Wang

“…We emphasize that intensive attention to neurological symptoms after general symptoms control, administration of adequate and appropriate prolonged immunosuppressive therapy, and long-term follow-up are essential for these patients.…”
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Molecular imaging of induced pluripotent stem cell immunogenicity with in vivo development in ischemic myocardium. by Zhiqiang Liu, Xinyu Wen, Haibin Wang, Jin Zhou, Mengge Zhao, Qiuxia Lin, Yan Wang, Junjie Li, Dexue Li, Zhiyan Du, Anning Yao, Feng Cao, Changyong Wang

“…Ascorbic acid (Vc) were used to induce iPSCs to differentiate into cardiomyocytes (CM). iPSCs and iPS-CMs were intramyocardially injected into immunocompetent or immunosuppressed allogenic murine with myocardial infarction. …”
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Chimeric antigen receptor natural killer cells: a promising antitumor immunotherapy by Yan Wang, Shengjie Jin, Qiqi Zhuang, Na Liu, Ruyi Chen, Sofia Abdulkadir Adam, Jie Jin, Jie Sun

“…Although the use of CAR NK cells is restrained by the limited proliferation and impaired efficiency within the immunosuppressive tumor microenvironment, further investigation in optimizing CAR structure and combination therapies will overcome these challenges. …”
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Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in hepatocellular carcinoma by Hongjun Xie, Muqi Shi, Yifei Liu, Changhong Cheng, Lining Song, Zihan Ding, Huanzhi Jin, Xiaohong Cui, Yan Wang, Dengfu Yao, Peng Wang, Min Yao, Haijian Zhang

“…Moreover, patients with high-risk scores had lower survival rates, higher infiltration of immunosuppressive cells (macrophages and Tregs), lower infiltration of cytotoxic immune cells (natural killer cells), poorer immune efficacy (both immunophenoscore and score of tumor immune dysfunction and exclusion), higher IC50, and enrichment of the induced Treg pathway, which confirmed that the mfrlncRNA signature contributed to survival prediction and risk stratification of patients with HCC.ConclusionsThe mfrlncRNA signature, which has great prognostic value, provides new clues for identifying “cold” and “hot” tumors and might have crucial implications for individualized therapy to improve the survival rate of patients with HCC.…”
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Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages by Tingting Chen, Jiayu Guo, Liqiang Ai, Yuquan Wang, Yan Wang, Bo Chen, Mingyue Liu, Shuping Zhuang, Kaidong Liu, Zhangxiang Zhao, Haihai Liang, Yunyan Gu

“…High-risk IPF patients exhibited an immunosuppressive microenvironment with higher oncogene expression than low-risk patients. …”
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Computational Recognition of a Regulatory T-cell-specific Signature With Potential Implications in Prognosis, Immunotherapy, and Therapeutic Resistance of Prostate Cancer by Mingyi Ju, Mingyi Ju, Jingyi Fan, Jingyi Fan, Yuanjiang Zou, Yuanjiang Zou, Mingjie Yu, Mingjie Yu, Longyang Jiang, Longyang Jiang, Qian Wei, Qian Wei, Jia Bi, Jia Bi, Baohui Hu, Baohui Hu, Qiutong Guan, Qiutong Guan, Xinyue Song, Xinyue Song, Mingyan Dong, Mingyan Dong, Lin Wang, Lin Wang, Lifeng Yu, Lifeng Yu, Yan Wang, Yan Wang, Hui Kang, Wei Xin, Wei Xin, Lin Zhao, Lin Zhao

“…Prostate cancer, recognized as a “cold” tumor, has an immunosuppressive microenvironment in which regulatory T cells (Tregs) usually play a major role. …”
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Identification of novel molecular subtypes and a signature to predict prognosis and therapeutic response based on cuproptosis-related genes in prostate cancer by Jili Zhang, Shaoqin Jiang, Shaoqin Jiang, Di Gu, Wenhui Zhang, Xianqi Shen, Min Qu, Chenghua Yang, Yan Wang, Xu Gao

“…Furthermore, 4D Label-Free LC-MS/MS and RNAseq were used to investigate the changes in CRGs at protein and RNA levels after the knockdown of the key model gene B4GALNT4.ResultsTwo cuproptosis-related molecular subtypes with significant differences in prognoses, clinical features, and the immune microenvironment were identified. Immunosuppressive microenvironments were associated with poor prognosis. …”
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