Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy by Yue Wang, Shi-Kun Zhou, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu, Jun Wang

“…Here the authors describe the design of a tumor-specific expression strategy to drive secretion of CXCL9 and an anti-PD-L1 scFv (αPD-L1) in the tumor microenvironment, promoting T cell recruitment and anti-tumor immune response in preclinical cancer models.…”
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A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility by Haiyang Li, Haonan Wang, Maofeng Jing, Jinyi Zhu, Baodian Guo, Yang Wang, Yachun Lin, Han Chen, Liang Kong, Zhenchuan Ma, Yan Wang, Wenwu Ye, Suomeng Dong, Brett Tyler, Yuanchao Wang

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Single-cell RNA sequencing reveals the Müller subtypes and inner blood–retinal barrier regulatory network in early diabetic retinopathy by Yan Wang, Xiongyi Yang, Qiumo Li, Yuxi Zhang, Lin Chen, Libing Hong, Zhuohang Xie, Siyu Yang, Xiaoqing Deng, Mingzhe Cao, Guoguo Yi, Min Fu

“…In endothelial cells, we found possible mechanisms of self-protection and adhesion and recruitment to pericytes. In addition, we constructed a communication network between endothelial cells, pericytes, and Müller subsets and clarified the complex regulatory relationship between cells. …”
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The mediating role of perceived social support: alexithymia and parental burnout in parents of children with autism spectrum disorder by Yuanting Lin, Yan Wang, Chunhui Lin, Qingnan Ni, Ruolin Jia, Yanling Chang, YuanPing Qi

“…However, the relationship between alexithymia, an independent personality factor, with parental burnout is little to none.ObjectiveTo look into the connection between parental burnout and alexithymia among parents of autistic children.MethodThree hundred and one parents were approached for recruitment and data were collected from 203 parents through a cross-sectional survey assessing parental burnout, alexithymia status, and perceived social support. …”
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Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis by Quanbo Ji, Dengbin Qi, Xiaojie Xu, Yameng Xu, Stuart B. Goodman, Lei Kang, Qi Song, Zhongyi Fan, William J. Maloney, Yan Wang

“…CTS promoted miR-106a-5p expression through recruitment of a member of the paired box (PAX) family of transcription factors, PAX5, to the miR-106a-5p promoter. …”
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Treatment preference and quality of life impact: ravulizumab vs eculizumab for atypical hemolytic uremic syndrome by Teri J Mauch, Michael R Chladek, Spero Cataland, Shruti Chaturvedi, Bradley P Dixon, Katherine Garlo, Anuja Java, Jorge Leguizamo, Lucy Lloyd-Price, Tan P Pham, Tara Symonds, Ioannis Tomazos, Yan Wang

“…Patients were required to have a diagnosis of aHUS, to be currently receiving treatment with ravulizumab and to have received prior treatment with eculizumab. Participants were recruited via various sources: the Alexion OneSource™ patient support program, the Rare Patient Voice recruitment agency, the aHUS Foundation and directly via a clinician involved in the study. …”

The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway by Yi Zhang, Xiaomeng Liu, Yan Wang, Shihui Lai, Zhiqian Wang, Yudie Yang, Wenhui Liu, Hongquan Wang, Bo Tang

“…Results DDIT4-AS1 was identified as one of the downstream targets of ALKBH5, and recruitment of HuR onto m6A-modified sites is essential for DDIT4-AS1 stabilization. …”
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Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 virus-induced acute lung injury by Yuan Tan, Yuan Tan, Yan Wang, Luciana Souza-Moreira, Chi Wang, Aidan B. P. Murray, Mahmoud Salkhordeh, Maria Florian, Lauralyn McIntyre, Lauralyn McIntyre, Duncan J. Stewart, Duncan J. Stewart, Shirley H. J. Mei

“…Further investigation revealed that MSCs were susceptible to IAV infection, leading to increased cell death and potentially affecting their efficacy.Conclusion: These findings provided in vivo evidence that MSCs promote the selective recruitment of immune cells to the site of infection during IAV infection, with reductions in proinflammatory phenotypes. …”
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KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer by Chengming Liu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Xinfeng Wang, Lu Yang, Haiyan Xu, Zheng Cao, Xiaoli Feng, Qi Xue, Yan Wang, Nan Sun, Jie He

“…Further analyses revealed that the combined treatment significantly enhanced the recruitment of CD8+ TILs via the up‐regulation of CXCL10/CXCL11 levels. …”
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Regorafenib alone or in combination with high/low-dose radiotherapy plus toripalimab as third-line treatment in patients with metastatic colorectal cancer: protocol for a prospecti... by Shujuan Zhou, Shujuan Zhou, Shujuan Zhou, Shujuan Zhou, Chenchen Wang, Lijun Shen, Lijun Shen, Lijun Shen, Lijun Shen, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Hui Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ruiyan Wu, Ruiyan Wu, Ruiyan Wu, Ruiyan Wu, Yaqi Wang, Yaqi Wang, Yaqi Wang, Yaqi Wang, Yajie Chen, Yajie Chen, Yajie Chen, Yajie Chen, Yan Xuan, Yan Xuan, Yan Xuan, Yan Xuan, Fan Xia, Fan Xia, Fan Xia, Fan Xia, Zhen Zhang, Zhen Zhang, Zhen Zhang, Zhen Zhang, Juefeng Wan, Juefeng Wan, Juefeng Wan, Juefeng Wan

“…The primary endpoint is the objective response rate, and the secondary endpoints are disease control rate, duration of remission, median progress-free survival, median overall survival, and adverse events. Recruitment started in August 2023 and is ongoing.Clinical Trial Registrationhttps://clinicaltrials.gov/study/NCT05963490?…”
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Serum total bilirubin and one-year prognosis of patients with coronary artery disease and psoriasis by Lin Sun, Lin Zhao, Kunqi Yang, Zuozhi Li, Yan Wang, Tianjie Wang, Man Wang, Yan Zeng, Xianliang Zhou, Weixian Yang

“…Summary: To evaluate the potential predictive value of total bilirubin (TBIL) for one-year prognosis in patients with coronary artery disease (CAD) and psoriasis. 278 psoriasis patients who underwent coronary angiography and were diagnosed as CAD were recruited. Baseline TBIL was measured at admission. …”
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Psychometric properties and normative data of the childhood trauma questionnaire-short form in Chinese adolescents by Chang Peng, Junhan Cheng, Fajuan Rong, Yan Wang, Yizhen Yu

“…However, psychometric properties and normative data of the CTQ-SF for Chinese adolescents are still unknown.ObjectiveTo examine psychometric properties and normative data of Chinese version CTQ-SF in a nationally representative sample of Chinese adolescents, including internal consistency reliability, test–retest reliability, structural validity, and convergent validity.MethodA total of 20,951 adolescents aged 12 to 18 years were recruited from five provinces across China. Item analysis was used for 25 clinical items of the CTQ-SF. …”
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Diabetes and Oral Health (DiabOH): The Perspectives of Primary Healthcare Providers in the Management of Diabetes and Periodontitis in China and Comparison with Those in Australia by Andrew Yun, Yuan Luo, Hanny Calache, Yan Wang, Ivan Darby, Phyllis Lau

“…Community medical practitioners (CMPs), community health nurses (CNs), and dentists in Shanghai were recruited to participate in online quantitative surveys. …”
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Neutrophil-mediated clinical nanodrug for treatment of residual tumor after focused ultrasound ablation by Jian Shen, Junnian Hao, Yini Chen, Hairong Liu, Jianrong Wu, Bing Hu, Yan Wang, Yuanyi Zheng, Xiaojun Cai

“…After HIFU ablation, PLD@NEs were recruited to the tumor site by inflammation (most in 4 h) and released PLD with inflammatory stimuli, leading to targeted and localized postoperative chemotherapy. …”
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Human Gait Data Augmentation and Trajectory Prediction for Lower-Limb Rehabilitation Robot Control Using GANs and Attention Mechanism by Yan Wang, Zhikang Li, Xin Wang, Hongnian Yu, Wudai Liao, Damla Arifoglu

“…The real human gait data are collected with the five healthy subjects recruited from an optical motion capture platform. …”
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The effects of alteration in muscle activation on the iliotibial band during an exhaustive run by Shane Fei Chen, Yan Wang, Fangbo Bing, Ming Zhang

“…Methods Twenty-five healthy participants (15 males, 10 females) were recruited in the current study. All participants performed a 30-minute exhaustive run at a self-selected speed with laboratory-provided footwear. …”
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Risk factors and a nomogram for predicting cognitive frailty in Chinese patients with lung cancer receiving drug therapy: A single‐center cross‐sectional study by Jinping Li, Yan Wang, Minfeng Zhai, Mengyuan Qin, Dandi Zhao, Qian Xiang, Zaoyuan Shao, Panrong Wang, Yan Lin, Yiting Dong, Yan Liu

“…Results A total of 372 patients were recruited, with a cognitive frailty prevalence of 56.2%. …”
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Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies by Yi Piao, Ru Ma, Yaohao Weng, Chuan Fan, Xinzhao Xia, Wei Zhang, Ginger Qinghong Zeng, Yan Wang, Zhuo Lu, Jiangtian Cui, Xiaoxiao Wang, Li Gao, Bensheng Qiu, Xiaochu Zhang

“…In this study, 38 healthy adults were recruited to undergo a series of neurological and neuropsychological measurements regarding safety concerns before and after active (2 mA, 20/70 Hz, 30 min) or sham (0 mA, 0 Hz, 30 min) TI-tACS. …”
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Ultrasound-Guided Rhomboid Block versus Paravertebral Block in Postoperative Analgesia for Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Clinical Trial by Yan Wang, Xiaoping Gu, Simin Huang, Minke Shi, Xiaofeng He, Zhengliang Ma

“…A total of 120 eligible patients were recruited, including 40 in each group. Baseline and surgery characteristics between the groups were comparable (all p>0.05). …”
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Ultrasound-guided versus Shikani optical stylet-aided tracheal intubation: a prospective randomized study by Yuanyuan Ma, Yan Wang, Ping Shi, Xue Cao, Shengjin Ge

“…Methods Sixty patients aged 18–65 years old who presented for elective surgery under general anesthesia were recruited in this prospective randomized study. They were assigned into two equal groups, either an ultrasound-guided group (Group UG, n = 30) or an SOS-aided group (Group SOS, n = 30). …”
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