Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration by Dong-Dong Wu, Yasmine Ahmed Salah, Ebenezeri Erasto Ngowi, Yan-Xia Zhang, Saadullah Khattak, Nazeer Hussain Khan, Yan Wang, Tao Li, Zi-Hua Guo, Yan-Mei Wang, Xin-Ying Ji

“…The main hurdle in delivering therapeutics to the brain has always been the blood-brain barrier which still represents an elusive area with lots of mysteries yet to be solved. …”
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Hot and cold tumors: Immunological features and the therapeutic strategies by Lianjie Wang, Hui Geng, Yujie Liu, Lei Liu, Yanhua Chen, Fanchen Wu, Zhiyi Liu, Shiliang Ling, Yan Wang, Lihong Zhou

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Neuregulin-1, a potential therapeutic target for cardiac repair by Yan Wang, Jianliang Wei, Peng Zhang, Xin Zhang, Yifei Wang, Wenjing Chen, Yanan Zhao, Yanan Zhao, Xiangning Cui

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Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities by Ruiqiang Qi, E. Lin, Juan Song, Yan Wang, Ling Lin

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TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia by Xinyu Tang, Ruirong Xu, Yan Wang, Kaiqing Chen, Siyuan Cui

“…In this study, we summarized the effects of TERC haploid cell reprogramming on telomere length and the correlation between this alteration and the pathogenesis of AA; by investigating the role of cell reprogramming in AA, we aimed to identify novel diagnostic indicators and therapeutic strategies for patients with AA.…”
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Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study by Yanghui Chen, Xin Xu, Linlin Wang, Ke Li, Yang Sun, Lei Xiao, Jiaqi Dai, Man Huang, Yan Wang, Dao Wen Wang

“…Methods: A Mendelian randomization (MR) analysis was conducted to identify therapeutic targets which are associated with AAs. Summary statistics for AAs were obtained from two datasets: the UK Biobank (2228 cases and 408,565 controls) and the FinnGen study (3658 cases and 244,907 controls). …”
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Cancer-Associated Fibroblast Risk Model for Prediction of Colorectal Carcinoma Prognosis and Therapeutic Responses by Yan Wang, Zhengbo Chen, Gang Zhao, Qiang Li

“…To predict the survival outcome and therapeutic responses of CRC patients, we identified genes connected with stromal CAF and generated a risk model. …”
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Identification of therapeutic targets for osteosarcoma by integrating single-cell RNA sequencing and network pharmacology by Yan Wang, Di Qin, Yiyao Gao, Yunxin Zhang, Yao Liu, Lihong Huang

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Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling by Qin Fang, Yang Bai, Shuiqing Hu, Jie Ding, Lei Liu, Meiyan Dai, Jie Qiu, Lujin Wu, Xiaoquan Rao, Yan Wang

“…Despite the approval of several drugs for PH treatment, their long-term therapeutic effect remains unsatisfactory, as they mainly focus on vasodilation rather than addressing vascular remodeling. …”
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Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy by Vanessa L. Hull, Yan Wang, Jennifer McDonough, Meina Zhu, Travis Burns, Najmah Al Ramel, Ali Dehghani, Fuzheng Guo, David Pleasure

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Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring by Jiayi Yin, Shiming Zhang, Chao Yang, Yan Wang, Bing Shi, Qian Zheng, Ni Zeng, Hanyao Huang

“…Hence, a thorough understanding of the underlying mechanisms is essential in the development of efficacious scar therapeutics. This review provides an overview of the current understanding of the mechanotransduction signaling pathways in scar formation and some strategies that offload mechanical forces in the wounded region for scar prevention and treatment.…”
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Revitalizing myocarditis treatment through gut microbiota modulation: unveiling a promising therapeutic avenue by Jingyue Wang, Jingyue Wang, Xianfeng Zhang, Xinyu Yang, Xinyu Yang, Hang Yu, Mengmeng Bu, Jie Fu, Zhengwei Zhang, Hui Xu, Jiachun Hu, Jinyue Lu, Haojian Zhang, Zhao Zhai, Wei Yang, Xiaodan Wu, Yan Wang, Qian Tong

“…However, the current therapeutic options for myocarditis are limited. In addition, little is known about the potential therapeutic targets of myocarditis. …”
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Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target by Qianru Leng, Jie Ding, Meiyan Dai, Lei Liu, Qing Fang, Dao Wen Wang, Lujin Wu, Yan Wang

“…Here, we will elaborate systematically the roles of platelet-derived miRNAs in cardiovascular disease and cancer in the hope of providing clinicians with new ideas for early diagnosis and therapeutic strategies.…”
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Therapeutic effects and mechanism of Atractylodis rhizoma in acute lung injury: Investigation based on an Integrated approach by Kun Shi, Yan Wang, Yangxin Xiao, Jiyuan Tu, Jiyuan Tu, Zhongshi Zhou, Zhongshi Zhou, Guosheng Cao, Guosheng Cao, Yanju Liu, Yanju Liu

“…We then characterized the chemical composition of EEAR by ultra-performance liquid chromatography and mass spectrometry (UPLC-MS) and screened the components and targets by network pharmacology to clarify the signaling pathways involved in the therapeutic effects of EEAR on ALI, and the results were validated by molecular docking simulation and Western blot (WB) analysis. …”
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Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy by Xinyu Tang, Zhenzhen Wang, Jingyi Wang, Siyuan Cui, Ruirong Xu, Yan Wang

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The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review by Peng Pi, Liqing Zeng, Zhipeng Zeng, Keqiang Zong, Keqiang Zong, Bing Han, Xizhe Bai, Yan Wang

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EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma by Qu-Jing Gai, Zhen Fu, Jiang He, Min Mao, Xiao-Xue Yao, Yan Qin, Xi Lan, Lin Zhang, Jing-Ya Miao, Yan-Xia Wang, Jiang Zhu, Fei-Cheng Yang, Hui-Min Lu, Ze-Xuan Yan, Fang-Lin Chen, Yu Shi, Yi-Fang Ping, You-Hong Cui, Xia Zhang, Xindong Liu, Xiao-Hong Yao, Sheng-Qing Lv, Xiu-Wu Bian, Yan Wang

“…Therefore, combination of inhibitors targeting PDGFRA and EHA2 represented a promising therapeutic strategy for GBM treatment.…”
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Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? by Meng Kou, Li Huang, Jinjuan Yang, Zhixin Chiang, Shaoxiang Chen, Jie Liu, Liyan Guo, Xiaoxian Zhang, Xiaoya Zhou, Xiang Xu, Xiaomei Yan, Yan Wang, Jinqiu Zhang, Aimin Xu, Hung-fat Tse, Qizhou Lian

“…There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. …”
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Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy by Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li, Yan Wang

“…The present study aims to explore the potential to enhance the therapeutic effect of exosome (EXO) from human CDCs to myocardial hypertrophy. …”
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Therapeutic Characterization of 131I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy for Glioblastoma by Fengqing Fu, Meng Zheng, Shandong Zhao, Yan Wang, Minzhou Huang, Hanqing Chen, Ziyi Huang, Kaijie Zhang, Liyan Miao, Xueguang Zhang

“…The PD analysis results indicated that 131I-hu4G4 had an excellent therapeutic effect and high safety with no apparent toxicity. …”
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