Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model by Longlong Zhang, Yuefei Zhu, Xunbin Wei, Xing Chen, Yang Li, Ying Zhu, Jiaxuan Xia, Yiheng Huang, Yongzhuo Huang, Jianxin Wang, Zhiqing Pang

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Immunomodulatory nano-preparations for rheumatoid arthritis by Chenglong Li, Yangyun Han, Xianjin Luo, Can Qian, Yang Li, Huaiyu Su, Guangshen Du

“…Although there are medications on the market that lessen disease activity, there is no known cure for RA, and patients are at risk in varying degrees of systemic immunosuppression. By transporting (encapsulating or surface binding) RA-related self-antigens, nucleic acids, immunomodulators, or cytokines, tolerogenic nanoparticles—also known as immunomodulatory nano-preparations—have the potential to gently regulate local immune responses and ultimately induce antigen-specific immune tolerance. …”
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Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19. by Theresa Kirchner, Sophia Heinrich, Agnes Bonifacius, Bastian Engel, Louisa Ruhl, Isabell Pink, Nele Thomas, Joerg Martens, Marius M Hoeper, Rainer Blasczyk, Heiner Wedemeyer, Elmar Jaeckel, Yang Li, Christine S Falk, Britta Eiz-Vesper, Richard Taubert

“…Mortality due to COVID-19 is not increased in immunosuppressed individuals after liver transplantation (OLT) compared to individuals without immunosuppression. …”
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Positive regulators of T cell functions as predictors of prognosis and microenvironment characteristics of low-grade gliomas by Yang Li, Yang Li, Yabo Feng, Fushu Luo, Gang Peng, Yueran Li

“…The efficacy of immunotherapy in LGG is limited compared to other cancers. Immunosuppression in the tumor microenvironment (TME) of LGG is one of the main reasons for the low efficacy of immunotherapy. …”
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CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals by Yang Li, Yan Wu, Elena A Federzoni, Xiaodan Wang, Andre Dharmawan, Xiaoyi Hu, Hui Wang, Robert J Hawley, Sean Stevens, Megan Sykes, Yong-Guang Yang

“…CD47 cross-dressing also suggests a previously unidentified mechanism for tumor-induced immunosuppression. Our findings should help to further optimize the CD47 transgenic approach that may improve outcomes by minimizing the harmful effects of CD47 overexpression.…”
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Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC by Lingqin Li, Fan Li, Zhehao Xu, Liyang Li, Haiyi Hu, Yang Li, Shicheng Yu, Mingchao Wang, Lei Gao

“…SERPINE1 expression was also associated with the expression of several immunoregulators and immune cell infiltration and could play an immunosuppression role. Besides, SERPINE1 was found to be related with TMB, MSI, immunotherapy response and sensitivity to several drugs in cancers. …”
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Comprehensive Profiling Analysis of CD209 in Malignancies Reveals the Therapeutic Implication for Tumor Patients Infected With SARS-CoV-2 by Jinyuan Li, Jinyuan Li, Shuzhao Chen, Shuzhao Chen, Yang Li, Yang Li, Ziang Zhu, Ziang Zhu, Hanying Huang, Hanying Huang, Weida Wang, Weida Wang, Yao Yang, Yang Liang, Yang Liang, Lingling Shu, Lingling Shu, Lingling Shu

“…Patients with malignant tumors may be particularly vulnerable to SARS-CoV-2 infection and possibly more susceptible to severe complications due to immunosuppression. Recent studies have found that CD209 (DC-SIGN) might be a potential binding receptor for SARS-CoV-2 in addition to the well-known receptor ACE2. …”
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Novel T cell exhaustion gene signature to predict prognosis and immunotherapy response in thyroid carcinoma from integrated RNA-sequencing analysis by Yang Li, Zhen Wang, Fangting Lu, Yahu Miao, Qing Feng, Weixi Zhu, Qingqing Kang, Yijing Chen, Qiu Zhang

“…Bulk RNA sequencing analysis revealed a higher prevalence of M2 macrophages, indicative of an immunosuppressive tumor microenvironment (TME), in the high-ERGS group. …”
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A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma by Chao Zhang, Hongru Shen, Tielong Yang, Ting Li, Xinyue Liu, Jin Wang, Zhichao Liao, Junqiang Wei, Jia Lu, Haotian Liu, Lijie Xiang, Yichen Yang, Meng Yang, Duan Wang, Yang Li, Ruwei Xing, Sheng Teng, Jun Zhao, Yun Yang, Gang Zhao, Kexin Chen, Xiangchun Li, Jilong Yang

“…Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas…”
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Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury by Xiao-Yu Zhu, Ting-Ting Ma, Yang Li, Ming-Qi Zhang, Liang Zhao, Jia Liang, Lian-Qiu Min

“…Fingolimod (FTY-720) is a newly developed immunosuppressant isolated from Cordyceps sinensis that exhibits a wide range of biological activities, and has recently attracted much attention for the treatment of ischemic cerebrovascular diseases. …”
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PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5 by Jia Song, Yang Liu, Yue Yin, Hui Wang, Xin Zhang, Yang Li, Xuyang Zhao, Guangze Zhang, Xiangyan Meng, Yan Jin, Dan Lu, Yuxin Yin

“…Collectively, our data uncover the immunosuppressive role of PTIR1 in tumorigenesis and propose that ADAR1-PTIR1-UCHL5 signaling is a potential cancer immunotherapeutic target.…”
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Recent advances of nanotechnology-based tumor vessel-targeting strategies by Dongjie Zhu, Yang Li, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Ting Zhao, Cheng Lu, Yuanyan Liu

“…Tumor vessel-targeting therapy has become an important and promising direction in anti-tumor therapy, with the development of five anti-tumor therapeutic strategies, including vascular disruption, anti-angiogenesis, vascular blockade, vascular normalization and breaking immunosuppressive TME. However, the insufficient drug accumulation and severe side effects of vessel-targeting drugs limit their development in clinical application. …”
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Erythroderma combined with deeper dermal dermatophytosis due to Trichophyton rubrum in a patient with myasthenia gravis: first case report and literature review by Henan Si, Yang Li, Zhiyang Huang, Yan Cui, Shanshan Li

“…Conclusions This case report shows that immunosuppressed patients with long histories of superficial mycoses tend to have a higher risk of developing invasive dermatophytic infections or disseminated fungal infections. …”
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Identification of Endoplasmic Reticulum Stress-Related Subtypes, Infiltration Analysis of Tumor Microenvironment, and Construction of a Prognostic Model in Colorectal Cancer by Baike Liu, Xiaonan Yin, Guangfu Jiang, Yang Li, Zhiyuan Jiang, Liming Qiang, Na Chen, Yating Fan, Chaoyong Shen, Lei Dai, Yuan Yin, Bo Zhang

“…Furthermore, spatial transcriptomics data were utilized to explore ER stress-related gene patterns in CRC tissues, and it was shown that ER stress phenotype involves in the formation of the immunosuppressive TME. This study demonstrated that ER stress-related gene patterns play a role in influencing the TME and predicting prognosis. …”
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Simultaneous Quantification of Seven Antifungal Agents in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry by Wenjing Li, Yang Li, Junlong Cai, Yue Wang, Yanan Liu, Hankun Hu, Liang Liu

“…Systemic antifungal agents are essential for high-risk patients undergoing immunosuppressive therapy or cancer chemotherapy because of the rapid increase in opportunistic fungal infections. …”
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Multi-omics profiling and digital image analysis reveal the potential prognostic and immunotherapeutic properties of CD93 in stomach adenocarcinoma by Baokang Wu, Lei Fu, Xingqi Guo, Huixin Hu, Yang Li, Yu Shi, Yizhou Zhang, Shukun Han, Chao Lv, Yu Tian

“…Our results revealed that CD93 expression was positively associated with most immunosuppressive genes (including PD-1, PD-L1, CTLA-4, and LAG3), immunostimulatory genes, HLA, chemokine, and chemokine receptor proteins in STAD. …”
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Exploring personalized treatment for cardiac graft rejection based on a four-archetype analysis model and bioinformatics analysis by Hongjie Shi, Ming Yuan, Jie Cai, Jiajun Shi, Yang Li, Qiaofeng Qian, Zhe Dong, Gaofeng Pan, Shaoping Zhu, Wei Wang, Jianliang Zhou, Xianwu Zhou, Jinping Liu

“…Although improvements in immunosuppressive therapies have significantly reduced the frequency of cardiac graft rejection, the incidences of T cell-mediated rejection (TCMR) and antibody-mediated rejection remain almost unchanged. …”
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The serum free triiodothyronine to free thyroxine ratio as a potential prognostic biomarker of chronic kidney disease in patients with glomerular crescents: A retrospective study by Liwen Zhang, Liwen Zhang, Liwen Zhang, Liwen Zhang, Yuxiao Wu, Yuxin Nie, Yuxin Nie, Yuxin Nie, Yuxin Nie, Wenlv Lv, Wenlv Lv, Wenlv Lv, Wenlv Lv, Yang Li, Yang Li, Yang Li, Yang Li, Bowen Zhu, Bowen Zhu, Bowen Zhu, Bowen Zhu, Shi Jin, Shi Jin, Shi Jin, Shi Jin, Ziyan Shen, Ziyan Shen, Ziyan Shen, Ziyan Shen, Fang Li, Fang Li, Fang Li, Fang Li, Hong Liu, Hong Liu, Hong Liu, Hong Liu, Yi Fang, Yi Fang, Yi Fang, Yi Fang, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding

“…Kaplan-Meier and Cox regression analyses were performed to evaluate the prognostic value of the FT3/FT4 ratio.ResultsThe age, haemoglobin, eGFR, urinary albumin-to-creatinine ratio, cardiac troponin T, N-terminal brain natriuretic peptide precursor, FT3, FT4, percentage of total crescents in non-globally sclerotic glomeruli, prevalences of hypertension, moderate to severe renal tubulopathy and crescentic nephritis, and proportion of patients receiving glucocorticoids and immunosuppressants were significantly different between high and low FT3/FT4 ratio groups (P < 0.05). …”
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DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus by Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang

“…Chicken infectious anemia (CIA) is an immunosuppressive disease caused by chicken infectious anemia virus (CIAV) that poses a great threat to the poultry industry worldwide. …”
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Identification of fatty acids synthesis and metabolism-related gene signature and prediction of prognostic model in hepatocellular carcinoma by Ai Zhengdong, Xing Xiaoying, Fu Shuhui, Liang Rui, Tang Zehui, Song Guanbin, Yang Li, Tang Xi, Liu Wanqian

“…Compared with cluster2, Cluster1 subtype exhibited a worse prognosis, higher risk, higher immunosuppressive cells infiltrations, higher immune escape, higher cancer stemness and enhanced treatment-resistant. …”
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