In Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment by Yang Liu, Lin Cui, Xiao Wang, Weiling Miao, Yongxu Ju, Tiandong Chen, Huiting Xu, Ning Gu, Fang Yang

“…Abstract Universal chemotherapy in glioblastoma patients causes chemoresistance and further limits immune cells by creating an immunosuppressive tumor microenvironment that are difficult to solve by single‐drug therapeutic approaches. …”
Get full text

Immunomodulatory Effect of <i>Flammulina rossica</i> Fermentation Extract on Healthy and Immunosuppressed Mice by Yingdi Dai, Sijia Ma, Yanyan Zhu, Andrey A. Gontcharov, Yang Liu, Qi Wang

“…The findings indicated that FREP possessed immunoregulatory activity in healthy mice and could improve the immune functions in immunosuppressive mice. Therefore, FREP could be exploited as an immunomodulatory agent and potential immunotherapeutic medicine for patients with inadequate immune function.…”
Get full text

Stress-Induced Immunosuppression Affects Immune Response to Newcastle Disease Virus Vaccine via Circulating miRNAs by Yufei Tian, Yang Liu, Qiuyuan Wang, Jie Wen, Yiru Wu, Jianwei Han, Chaolai Man

Subjects: Get full text

Single‐Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T‐Cell Lymphoma by Yi‐Qi Li, Chun‐Ling Luo, Jia‐Xin Jiang, Shuai He, Yang Liu, Wen‐Xin Yan, Yi Xia, Qian Cui, Ying Huang, Jing Quan Lim, Dachuan Huang, Izzah Nabilah Hussein, Yan Gao, Guo‐Wang Lin, Yi‐Hong Ling, Dong Ma, Yue‐Tong Zhang, Jason Yongsheng Chan, Pan‐Pan Wei, Xiao‐Xiao Wang, Chee Leong Cheng, Jie Xiong, Wei‐Li Zhao, Choon Kiat Ong, Soon Thye Lim, Hui‐Qiang Huang, Rou‐Jun Peng, Jin‐Xin Bei

Subjects: Get full text

Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro by Xiaofeng Niu, Jiabao Yu, Qiuxia Huang, Jinjin Yu, Yajie Yang, Huixin Song, Yang Liu, Xin Xiao, Langjun Cui, Weifeng Li

Subjects: Get full text

Immune Evasion of <i>Mycoplasma gallisepticum</i>: An Overview by Yang Liu, Yongqiang Wang, Shijun J. Zheng

“…In addition, the pathogen can cause immunological damage to organs by inducing an inflammatory response, cell apoptosis, and oxidative stress, leading to immunosuppression in the host. This review comprehensively summarizes these evasion tactics employed by <i>M. gallisepticum</i>, providing valuable insights into better prevention and control of mycoplasma infection.…”
Get full text

Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression by Zhuang Chen, Qiming Wang, Jinbo Liu, Wenkang Wang, Weitang Yuan, Yang Liu, Zhenqiang Sun, Chengzeng Wang

“…In this review, we summarized the effects of EV-ncRNAs on the PMN in terms of immunosuppression, vascular permeability and angiogenesis, inflammation, metabolic reprogramming, and fibroblast alterations. …”
Get full text

Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis by Simin Li, Mingxin He, Yumeng Lei, Yang Liu, Xinquan Li, Xiaochen Xiang, Qingming Wu, Qiang Wang

“…This review systemically discusses the recent advances in the field of oral microecology and tumor, including the oncogenic role of oral microbial abnormalities and various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, and carcinogen secretion) to introduce future directions for effective tumor prevention.…”
Get full text

Targeted delivery of Fc-fused PD-L1 for effective management of acute and chronic colitis by Xudong Tang, Yangyang Shang, Hong Yang, Yalan Song, Shan Li, Yusi Qin, Jingyi Song, Kang Chen, Yang Liu, Dinglin Zhang, Lei Chen

“…However, systemic PD-L1 administration may cause unpredictable adverse effects due to immunosuppression. Here we show that reactive oxygen species (ROS)-responsive nanoparticles enhance the efficacy and safety of PD-L1 in a mouse colitis model. …”
Get full text

The pathogenesis of DLD-mediated cuproptosis induced spinal cord injury and its regulation on immune microenvironment by Chaochen Li, Chaochen Li, Chaochen Li, Chunshuai Wu, Chunshuai Wu, Chunshuai Wu, Chunyan Ji, Chunyan Ji, Chunyan Ji, Guanhua Xu, Jiajia Chen, Jinlong Zhang, Hongxiang Hong, Yang Liu, Zhiming Cui, Zhiming Cui, Zhiming Cui

“…Immune infiltration analysis indicated a significant decrease in T cell numbers in ASCI patients, while M2 macrophage numbers were significantly increased and positively correlated with DLD expression.DiscussionIn summary, our study demonstrated that DLD affects the ASCI immune microenvironment by promoting copper toxicity, leading to increased peripheral M2 macrophage polarization and systemic immunosuppression. Thus, DLD has potential as a promising biomarker for ASCI, providing a foundation for future clinical interventions.…”
Get full text

Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy by Xiaoyan Ge, Yanyun Hao, Hui Li, Huajun Zhao, Yang Liu, Yutong Liu, Xia Li, Hongfei Chen, Jing Zou, Shiying Zhang, Lingling Huang, Gang Shan, Zhiyue Zhang

“…Abstract Background Immunosuppressive tumor immune microenvironment (TIME) lowers immunotherapy effectiveness. …”
Get full text

CCR7-mediated T follicular helper cell differentiation is associated with the pathogenesis and immune microenvironment of spinal cord injury-induced immune deficiency syndrome by Chaochen Li, Chaochen Li, Chaochen Li, Chunshuai Wu, Chunshuai Wu, Chunshuai Wu, Guanhua Xu, Yang Liu, Jiajia Chen, Jinlong Zhang, Hongxiang Hong, Chunyan Ji, Chunyan Ji, Chunyan Ji, Zhiming Cui, Zhiming Cui, Zhiming Cui

“…Spinal cord injury-induced immune deficiency syndrome (SCI-IDS) is a disorder characterized by systemic immunosuppression secondary to SCI that dramatically increases the likelihood of infection and is difficult to treat. …”
Get full text

The Structural Characterization and Immunomodulatory Activity of Polysaccharides from <i>Pleurotus abieticola</i> Fruiting Bodies by Meichen Pan, Fange Kong, Lei Xing, Lan Yao, Yu Li, Yang Liu, Changtian Li, Lanzhou Li

“…After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days. …”
Get full text

Non-coding RNA in tumor-infiltrating regulatory T cells formation and associated immunotherapy by Yue Ma, Xin Xu, Huaitao Wang, Yang Liu, Haiyan Piao

“…Infiltrated regulatory T cells (Tregs) in the tumor microenvironment (TME) restrict protective immune surveillance, impede effective antitumor immune responses, and contribute to the formation of an immunosuppressive microenvironment. Selective depletion or functional attenuation of tumor-infiltrating Tregs, while eliciting effective T-cell responses, represents a potential approach for anti-tumor immunity. …”
Get full text

The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification by Xiaohuan Peng, Xiaohuan Peng, Xiaofeng Zhu, Xiaofeng Zhu, Tianning Di, Tianning Di, Futian Tang, Xiaojia Guo, Yang Liu, Jun Bai, Yanhong Li, Lijuan Li, Lijuan Li, Liansheng Zhang, Liansheng Zhang

“…Lower-risk MDS (LR-MDS) is mainly characterized by immune hyperfunction and increased apoptosis, and the immunosuppressive therapy shows a good response. Instead, higher-risk MDS (HR-MDS) is characterized by immune suppression and immune escape, and the immune activation therapy may improve the survival of HR-MDS. …”
Get full text

Hijacking Self‐Assembly to Establish Intracellular Functional Nanoparticles by Yang Liu, Yuchen Wang, Chao Wang, Tiejun Dong, Haiheng Xu, Yunfei Guo, Xiaozhi Zhao, Yiqiao Hu, Jinhui Wu

“…Unlike free drugs, the generated intercellular nanoparticles can specifically stress mitochondria, resulting in immune activation of macrophages in vitro and polarizing tumor‐associated macrophages (TAMs) from immunosuppressive to tumoricidal and increasing the recruitment of T cells deep within tumor. …”
Get full text

How are MCPIP1 and cytokines mutually regulated in cancer-related immunity? by Ruyi Xu, Yi Li, Yang Liu, Jianwei Qu, Wen Cao, Enfan Zhang, Jingsong He, Zhen Cai

“…Monocyte chemoattractant protein-1 induced protein 1 (MCPIP1), a potent immunosuppressive protein, was first described as a transcription factor in monocytes treated with monocyte chemoattractant protein-1 (MCP-1) and subsequently found to possess intrinsic RNase and deubiquitinase activities. …”
Get full text

PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5 by Jia Song, Yang Liu, Yue Yin, Hui Wang, Xin Zhang, Yang Li, Xuyang Zhao, Guangze Zhang, Xiangyan Meng, Yan Jin, Dan Lu, Yuxin Yin

“…Collectively, our data uncover the immunosuppressive role of PTIR1 in tumorigenesis and propose that ADAR1-PTIR1-UCHL5 signaling is a potential cancer immunotherapeutic target.…”
Get full text

Nanotechnology: A New Strategy for Lung Cancer Treatment Targeting Pro-Tumor Neutrophils by Jian Zhang, Shasha Jiang, Shilin Li, Jipeng Jiang, Jie Mei, Yandong Chen, Yongfu Ma, Yang Liu, Ying Liu

“…Neutrophils can be classified into various categories according to different criteria; frequent categories include N1 antitumor neutrophils and N2 immunosuppressive neutrophils. The antitumor effects of neutrophils are reported to be mediated through a combination of reactive oxygen species, tumor necrosis factor-related apoptosis-inducing ligand, and receptor for advanced glycation end-products–cathepsin G association, as well as the regulation of the activities of other immune cells. …”
Get full text

Advances in immunotherapy for triple-negative breast cancer by Yang Liu, Yueting Hu, Jinqi Xue, Jingying Li, Jiang Yi, Jiawen Bu, Zhenyong Zhang, Peng Qiu, Xi Gu

“…It also suppresses immunosuppressive molecules, activates or restores immune system function, enhances anti-tumor immune responses, and inhibits the growth f tumor cell. …”
Get full text