NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis by Wei-yu Zhou, Pei Liu, Yi-fan Xia, Yi-jie Shi, Hong-yu Xu, Meng Ding, Qi-qi Yang, Shu-wen Qian, Yan Tang, Yan Lu, Qi-qun Tang, Yang Liu

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Selective Expression of a SNARE-Cleaving Protease in Peripheral Sensory Neurons Attenuates Pain-Related Gene Transcription and Neuropeptide Release by Wanzhi Wang, Miaomiao Kong, Yu Dou, Shanghai Xue, Yang Liu, Yinghao Zhang, Weiwei Chen, Yanqing Li, Xiaolong Dai, Jianghui Meng, Jiafu Wang

“…Moreover, the transcripts of pain-related genes (<i>TAC1, tachykinin precursor 1;</i> <i>CALCB, calcitonin gene-related peptide 2; HTR3A, 5-hydroxytryptamine receptor 3A;</i> <i>NPY2R, neuropeptide Y receptor Y2;</i> <i>GPR52, G protein-coupled receptor 52;</i> <i>SCN9A, sodium voltage-gated channel alpha subunit 9;</i> <i>TRPV1</i> and <i>TRPA1, transient receptor potential cation channel subfamily V member 1</i> and <i>subfamily A member 1)</i> in pro-inflammatory cytokines stimulated sensory neurons were downregulated by viral mediated expression of LCA. …”
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Challenges and Perspectives in the Study of Self-Incompatibility in Orchids by Xiaojing Zhang, Yin Jia, Yang Liu, Duanfen Chen, Yibo Luo, Shance Niu

“…In recent years, phenotypic and multiple omics studies have revealed that self-incompatibility in <i>Orchidaceae</i> is mainly concentrated in the subfamily <i>Epidendroideae</i>, and the self-incompatibility phenotypes are diverse, even in the same genus, and hormones (auxin and ethylene), and new male and female determinants might be involved in SI response. …”
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Genome-Wide Analysis of the bHLH Gene Family in <i>Loropetalum chinense</i> var. <i>rubrum</i>: Identification, Classification, Evolution, and Diversity of Expression Patterns unde... by Yang Liu, Ling Lin, Yang Liu, Qiong Mo, Damao Zhang, Weidong Li, Xingyao Xiong, Xiaoying Yu, Yanlin Li

“…Based on an evolutionary comparison with proteins from <i>Arabidopsis</i> and <i>Oryza sativa</i>, these bHLH proteins were categorized into 21 subfamilies. Most LcbHLHs in a particular subfamily had similar gene structures and conserved motifs. …”
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Chromosome-level genome assembly of the spotted alfalfa aphid Therioaphis trifolii by Tianyu Huang, Yang Liu, Kang He, Frédéric Francis, Bing Wang, Guirong Wang

“…Here, we present a chromosome-scale genome assembly of T. trifolii, the first genome assembly for the aphid subfamily Calaphidinae. Using PacBio long-read sequencing, Illumina sequencing, and Hi-C scaffolding techniques, a 541.26 Mb genome was generated, with 90.01% of the assembly anchored into eight scaffolds, and the contig and scaffold N50 are 2.54 Mb and 44.77 Mb, respectively. …”
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Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation by Jian-Wu Shi, Yi-Wen Zhou, Yu-Fei Chen, Mei Ye, Feng Qiao, Jia-Wei Tian, Meng-Ya Zhang, Hao-Cheng Lin, Gang-Cai Xie, Kin Lam Fok, Hui Jiang, Yang Liu, Hao Chen

“…This study aims to characterize the cell atlas of the epididymis derived from a 46,XY disorders of sex development (DSD) patient with a novel heterozygous mutation of the nuclear receptor subfamily 5 group A member 1 (NR5A1) gene. Next-generation sequencing found a heterozygous c.124C>G mutation in NR5A1 that resulted in a p.Q42E missense mutation in the conserved DNA-binding domain of NR5A1. …”
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Role of differentiated embryo-chondrocyte expressed gene 2 in immunity by Yujing Li, Yujing Li, Yinan Ma, Yinan Ma, Yang Liu, Na Tang, Na Tang, Wenzhu Zhang, Wenzhu Zhang, Jingru Huo, Jingru Huo, Di Zhang, Di Zhang

“…Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. …”
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Acquisition of T6SS Effector TseL Contributes to the Emerging of Novel Epidemic Strains of Pseudomonas aeruginosa by Anmin Ren, Minlu Jia, Jihong Liu, Tian Zhou, Liwen Wu, Tao Dong, Zhao Cai, Jiuxin Qu, Yang Liu, Liang Yang, Yingdan Zhang

“…We experimentally validated that this TseL homologue belongs to the Tle2, a subfamily of T6SS-lipase effectors; thereby, we name this effector TseL (TseLPA in this work). …”
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Genome-Wide Identification and Expression Profile Analysis of the Phospholipase C Gene Family in Wheat (<i>Triticum aestivum</i> L.) by Xianguo Wang, Yang Liu, Zheng Li, Xiang Gao, Jian Dong, Jiacheng Zhang, Longlong Zhang, Linda S. Thomashow, David M. Weller, Mingming Yang

“…Phylogenetic and sequence alignment analyses divided the wheat PLC genes into 2 subfamilies, <i>TaPI-PLC</i> (containing the typical X, Y, and C2 domains) and <i>TaNPC</i> (containing a phosphatase domain). …”
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Genome-Wide Analysis of the <i>Peptidase M24</i> Superfamily in <i>Triticum aestivum</i> Demonstrates That <i>TaM24-9</i> Is Involved in Abiotic Stress Response by Lu-Yu Yan, Jia-Gui Guo, Xin Zhang, Yang Liu, Xin-Xin Xiong, Yu-Xuan Han, Li-Li Zhang, Xiao-Hong Zhang, Dong-Hong Min

“…According to the protein sequences characteristics, these members can be roughly divided into three subfamilies: I, II, III. Most <i>TaM24</i> genes are complex with multiple exons, and the motifs are relatively conserved in each sub-group. …”
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Genome-Wide Analysis of <i>R2R3-MYB</i> Genes and Functional Characterization of <i>SmMYB75</i> in Eggplant Fruit Implications for Crop Improvement and Nutritional Enhancement by Suli Shi, Dalu Li, Shaohang Li, Na Zhao, Jielei Liao, Haiyan Ge, Yang Liu, Huoying Chen

“…In this study, 102 <i>SmR2R3-MYB</i> genes were identified from eggplant fruit and classified into 31 subfamilies. Analysis indicated that segmental duplication events played a pivotal role in the expansion of the <i>SmR2R3-MYB</i> gene family. …”
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