Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses by Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo Jr., Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi

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Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma by Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Qingsong Cai, Ruitao Lin, Fangfang Yan, Joseph McIntosh, Yijing Li, Yuxuan Che, Zhihong Chen, Jovanny Vargas, Maria Badillo, John Nelson Bigcal, Heng-Huan Lee, Wei Wang, Yixin Yao, Lei Nie, Christopher R. Flowers, Michael Wang

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Therapeutic strategies for intracerebral hemorrhage by Zhe Li, Zhe Li, Zhe Li, Suliman Khan, Suliman Khan, Suliman Khan, Yang Liu, Yang Liu, Yang Liu, Ruixue Wei, Ruixue Wei, Ruixue Wei, V. Wee Yong, Mengzhou Xue, Mengzhou Xue, Mengzhou Xue

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An insight into novel therapeutic potentials of taxifolin by Yang Liu, Xiaolu Shi, Ye Tian, Shaobo Zhai, Yuyan Liu, Zhengrong Xiong, Shunli Chu

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Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases by Longwei Zhao, Jianlou Niu, Huan Lin, Jing Zhao, Yang Liu, Zihui Song, Congshang Xiang, Xiaojie Wang, Yong Yang, Xiaokun Li, Moosa Mohammadi, Zhifeng Huang

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The Screening of Therapeutic Peptides for Anti-Inflammation through Phage Display Technology by Kangran Zhang, Yezhong Tang, Qin Chen, Yang Liu

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Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects by Jikai He, Haijun Li, Jiaqi Jia, Yang Liu, Ning Zhang, Rumeng Wang, Wenhao Qu, Yanqi Liu, Lizhou Jia

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FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer by Na Liu, Anran Wang, Mengen Xue, Xiaoren Zhu, Yang Liu, Minbin Chen

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Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target by Huan Zhao, Xueying Tian, Lingjuan He, Yan Li, Wenjuan Pu, Qiaozhen Liu, Juan Tang, Jiaying Wu, Xin Cheng, Yang Liu, Qingtong Zhou, Zhen Tan, Fan Bai, Fei Xu, Nicola Smart, Bin Zhou

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Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in ovarian cancer by Dan Yang, Yang He, Bo Wu, Yan Deng, Nan Wang, Menglin Li, Yang Liu

“…This study aims to identify hub genes and therapeutic drugs involved in OC. Methods Four gene expression profiles (GSE54388, GSE69428, GSE36668, and GSE40595) were downloaded from the Gene Expression Omnibus (GEO), and the differentially expressed genes (DEGs) in OC tissues and normal tissues with an adjusted P-value < 0.05 and a |log fold change (FC)| > 1.0 were first identified by GEO2R and FunRich software. …”
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Tenascin-C as a potential biomarker and therapeutic target for esophageal squamous cell carcinoma by Yang Liu, Li-Yan Yang, Ding-Xiong Chen, Chen Chang, Qing Yuan, Yu Zhang, Yan Cai, Wen-Qiang Wei, Jia-Jie Hao, Ming-Rong Wang

“…Purpose: To establish a prognostic model of esophageal squamous cell carcinoma (ESCC) patients based on tenascin-C (TNC) expression level and clinicopathological characteristics, and to explore the therapeutic potential of TNC inhibition. Methods: The expression of TNC was detected using immunohistochemistry (IHC) in 326 ESCC specimens and 50 normal esophageal tissues. …”
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Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment by Yang Liu, Yiming Dou, Xun Sun, Qiang Yang

“…It is expected that further understanding of the underlying mechanism between cellular senescence pathology and intervertebral disc degeneration will help to formulate reasonable senescence regulation strategies, so as to achieve ideal therapeutic effects. The translational potential of this article: Existing treatment strategies often fall short in addressing the challenge of repairing intervertebral disc Intervertebral disc degeneration（IVD） degeneration. …”
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Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer by Yang Liu, Yu Fang, Lili Bao, Feng Wu, Shilong Wang, Siyu Hao

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Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1 by Shanxi Wang, Yunkun Qu, Xuan Fang, Qing Ding, Hongqi Zhao, Xiaojun Yu, Tao Xu, Rui Lu, Shaoze Jing, Chaoxu Liu, Hua Wu, Yang Liu

“…These findings imply that DCN is a potential therapeutic candidate for ligamentum flavum hypertrophy.…”
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Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies by Yan Li, Chen Xu, Bing Wang, Fujiang Xu, Fahan Ma, Yuanyuan Qu, Dongxian Jiang, Kai Li, Jinwen Feng, Sha Tian, Xiaohui Wu, Yunzhi Wang, Yang Liu, Zhaoyu Qin, Yalan Liu, Jing Qin, Qi Song, Xiaolei Zhang, Akesu Sujie, Jie Huang, Tianshu Liu, Kuntang Shen, Jian-Yuan Zhao, Yingyong Hou, Chen Ding

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The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma by Fangfang Yan, Vivian Jiang, Alexa Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yu Xue, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Lei Nie, Yixin Yao, Heng-Huan Lee, Wei Wang, JohnNelson R. Bigcal, Maria Badillo, Jitendra Meena, Christopher Flowers, Jia Zhou, Zhongming Zhao, Lukas M. Simon, Michael Wang

“…Collectively, our study revealed that HSP90-MYC-CDK9 network is the primary driving force of therapeutic resistance.…”
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Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer by Hua Su, Chao Peng, Yang Liu

“…The global challenge posed by cancer, marked by rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. The PI3K/Akt signaling pathway, frequently amplified in various cancers, is central in regulating essential cellular processes. …”
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Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression by Huanhuan Li, Feng Yang, Anpei Hu, Xiaojing Wang, Erhu Fang, Yajun Chen, Dan Li, Huajie Song, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Kai Huang, Liduan Zheng, Qiangsong Tong

“…These results indicate circ‐CUX1/EWSR1/MAZ axis as a therapeutic target for aerobic glycolysis and NB progression.…”
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Deciphering the tumor microenvironment cell–infiltrating landscape reveals microenvironment subtypes and therapeutic potentials for nonsquamous NSCLC by Hao Chen, Tongchao Zhang, Yuan Zhang, Hao Wu, Zhen Fang, Yang Liu, Yang Chen, Zhe Wang, Shengtao Jia, Xingzhao Ji, Liang Shang, Fengying Du, Jin Liu, Ming Lu, Wei Chong

“…Recent studies highlighted the clinicopathologic importance of the tumor microenvironment (TME) in delineating molecular attributes and therapeutic potentials. However, the overall TME cell infiltration landscape in nonsquamous non–small cell lung cancer (NSCLC) has not been comprehensively characterized. …”
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Superoxide dismutase ameliorates oxidative stress and regulates liver transcriptomics to provide therapeutic benefits in hepatic inflammation by Longyan Chen, Yang Liu, Yonggang Zhang, Yanmin Zhang, Wei Wang, Hongyu Han, Chunyu Yang, Xueqian Dong

“…Conclusion Our research verified the oxidative stress remediation effects of superoxide dismutase and its therapeutic role against hepatic inflammation. This study can lay a foundation for investigating the mechanism by which superoxide dismutase alleviates hepatic disease.…”
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