mRNA-Based Therapeutics in Cancer Treatment by Han Sun, Yu Zhang, Ge Wang, Wen Yang, Yingjie Xu

“…Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. …”
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Ribosome biogenesis in disease: new players and therapeutic targets by Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li

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The therapeutic potential of natural products for treating pancreatic cancer by Xia He, Ning Wang, Yu Zhang, Xiaobo Huang, Yi Wang

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Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure by Yi Wang, Jing Yang, Yu Zhang, Jianhua Zhou

“…This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.…”
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Mitochondria-associated endoplasmic reticulum membranes (MAMs): Possible therapeutic targets in heart failure by Yu Zhang, Jiayu Yao, Mingming Zhang, Yushan Wang, Xingjuan Shi

“…Elucidating these issues may provide important insights into therapeutic intervention of heart failure.…”
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Tenascin-C as a potential biomarker and therapeutic target for esophageal squamous cell carcinoma by Yang Liu, Li-Yan Yang, Ding-Xiong Chen, Chen Chang, Qing Yuan, Yu Zhang, Yan Cai, Wen-Qiang Wei, Jia-Jie Hao, Ming-Rong Wang

“…Purpose: To establish a prognostic model of esophageal squamous cell carcinoma (ESCC) patients based on tenascin-C (TNC) expression level and clinicopathological characteristics, and to explore the therapeutic potential of TNC inhibition. Methods: The expression of TNC was detected using immunohistochemistry (IHC) in 326 ESCC specimens and 50 normal esophageal tissues. …”
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PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma by Fei Song, Cheng-Gui Wang, Jia-Zhen Mao, Tian-Lun Wang, Xiao-Liang Liang, Chen-Wei Hu, Yu Zhang, Lu Han, Zhong Chen

“…Our findings underscore the role of YWHAB in Sorafenib resistance, presenting valuable insights for personalized therapeutic strategy development in HCC.…”
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Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges by Yanchao Chen, Jing Yang, Qinchun Rao, Chen Wang, Xiaoyong Chen, Yu Zhang, Huayi Suo, Jiajia Song

“…Protein peptides derived from food offer advantages such as a wide range of sources, significant therapeutic benefits, and minimal adverse effects. However, they also face challenges in terms of commercialization. …”
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Newcastle disease virus expressing an angiogenic inhibitor exerts an enhanced therapeutic efficacy in colon cancer model. by Fanrui Meng, Yukai Cao, Han Su, Tianyan Liu, Limin Tian, Yu Zhang, Jiarui Yang, Wei Xiao, Deshan Li

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A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART) by Niloofar Heshmati Aghda, Yu Zhang, Jiawei Wang, Anqi Lu, Amit Raviraj Pillai, Mohammed Maniruzzaman

“…This method is based on an additive manufacturing technology that allows for the designing and production of personalized particulate based therapeutic formulations with a precise control over the shape, size, and potentially the geometry. …”
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A lactate-related LncRNA model for predicting prognosis, immune landscape and therapeutic response in breast cancer by Jia Li, Yinbin Zhang, Chaofan Li, Huizi Wu, Cong Feng, Weiwei Wang, Xuan Liu, Yu Zhang, Yifan Cai, Yiwei Jia, Hao Qiao, Fei Wu, Shuqun Zhang

“…Increasing evidence shows that lactate and long non-coding RNA (lncRNA) play a critical role in tumor occurrence, maintenance, therapeutic response, and immune microenvironment. We aimed to construct a lactate-related lncRNAs prognostic signature (LRLPS) for BC patients to predict prognosis, tumor microenvironment, and treatment responses. …”
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The research progress of anti-inflammatory and anti-fibrosis treatment of chronic pancreatitis by Bing-Qing Li, Xin-Yuan Liu, Tao Mao, Tao-Hua Zheng, Peng Zhang, Qi Zhang, Yu Zhang, Xiao-Yu Li

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An epithelial–mesenchymal transition-related mRNA signature associated with the prognosis, immune infiltration and therapeutic response of colon adenocarcinoma by Yu Zhang, Yu Zhang, Yan Li, Yan Li, Zan Zuo, Zan Zuo, Ting Li, Ting Li, Ying An, Ying An, Wenjing Zhang, Wenjing Zhang

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A humanized knockin mouse model of Duchenne muscular dystrophy and its correction by CRISPR-Cas9 therapeutic gene editing by Yu Zhang, Hui Li, Takahiko Nishiyama, John R. McAnally, Efrain Sanchez-Ortiz, Jian Huang, Pradeep P.A. Mammen, Rhonda Bassel-Duby, Eric N. Olson

“…This unique DMD mouse model with the human genomic sequence allows in vivo assessment of clinically relevant gene editing strategies as well as other therapeutic approaches and represents a significant step toward therapeutic translation of CRISPR-Cas9 gene editing for correction of DMD.…”
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MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis by Junqing Gan, Shan Liu, Yu Zhang, Liangzi He, Lu Bai, Ran Liao, Juan Zhao, Madi Guo, Wei Jiang, Jiade Li, Qi Li, Guannan Mu, Yangjiazi Wu, Xinling Wang, Xingli Zhang, Dan Zhou, Huimin Lv, Zhengfeng Wang, Yanqiao Zhang, Cheng Qian, MeiYan Feng, Hui Chen, Qingwei Meng, Xiaoyi Huang

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A novel sphingolipid metabolism-related long noncoding RNA signature predicts the prognosis, immune landscape and therapeutic response in pancreatic adenocarcinoma by Xiaolan He, Zhengyang Xu, Ruiping Ren, Peng Wan, Yu Zhang, Liangliang Wang, Ying Han

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A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications by Yongxin Zheng, Jinping Wang, Zhaoyi Ling, Jiamei Zhang, Yuan Zeng, Ke Wang, Yu Zhang, Lingbo Nong, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li, Yongbo Huang

“…The diagnostic model could identify septic patients at high risk of ALI, and provide potential therapeutic targets for sepsis-induced ALI.…”
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Multiply restimulated human cord blood-derived Tregs maintain stabilized phenotype and suppressive function and predict their therapeutic effects on autoimmune diabetes by Yuanjie Bi, Ran Kong, Yani Peng, Donghua Cai, Yu Zhang, Fan Yang, Xia Li, Wen Deng, Fang Liu, Binbin He, Chuqing Cao, Chao Deng, Xiaohan Tang, Li Fan, Haibo Yu, Zhiguang Zhou

“…The present study revealed the possibility of predicting the in vivo therapeutic effects via the in vitro inhibition assay. …”
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Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers by Yu Zhang, Xinliang Gu, Yang Li, Yuejiao Huang, Shaoqing Ju

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A novel glycolysis-related gene signature for predicting the prognosis of multiple myeloma by Bingxin Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Tianyu Zhang, Dong Zheng, Zixing Chen, Sisi Zheng, Yu Zhang, Xuanru Lin, Rujiao Dong, Jingjing Chen, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

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