New approaches in drug safety assessment based on information provided by doctors and patients in the register “PROFILE” by N. A. Dmitrieva, Yu. V. Lukina, N. P. Kutishenko, S. Yu. Martsevich

“…Of the 162 patients who answered the questions in the original questionnaire, there were 80 women and 82 men. 112 patients were observed by doctors regularly (at least 1 time per year), 16 people visited doctors 1 time in 1–2 years, 14 people were with a doctor more than 2 years ago, in 18 patients information on the regularity of observation by doctors is not indicated were. …”
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Assessment of adherence to medication and visits in healthcare facilities for cardiovascular patients who participated in international randomized controlled trials by N. O. Vasyukova, Yu. V. Lukina, O. I. Zvonareva, V. P. Voronina, S. N. Tolpygina, N. A. Dmitrieva, O. V. Lerman, A. V. Zagrebelny, I. V. Budaeva, E. S. Nekoshnova, N. P. Kutishenko, S. Yu. Martsevich

“…The TRUST (Influence of Participation in Randomized Controlled Trials on adheRence to Medicines’ Intake and regular viSits to the docTor) study included patients from the outpatient register PROFILE. …”
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The Study of Adherence to Drug Therapy at the Stage of Outpatient Follow-up in Patients with Acute Myocardial Infarction (Data from the PROFIL-IM Registry) by E. P. Kalaydzhyan, N. P. Kutishenko, Yu. V. Lukina, D. P. Sichinava, S. Yu. Martsevich, O. M. Drapkina

“…Patients' adherence to therapy was assessed using the original questionnaire "Scale of Adherence of the National Society of Evidence-based Pharmacotherapy" (NODF) and a direct standardized patient survey by a doctor about taking medications. Visits to the doctor were carried out every two months,  data from the first year of patient follow-up are presented.Results. …”
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TREATMENT ADHERENCE AND QUALITY OF LIFE OF PATIENTS WITH STABLE ISCHEMIC HEART DISEASE IN TREATMENT WITH NICORANDIL: INTERRELATION AND INTERACTION (ACCORDING TO THE RESULTS OF THE... by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, V. P. Voronina, O. V. Lerman, O. V. Gaisenok, T. A. Gomova, A. V. Ezhov, A. D. Kuimov, R. A. Libis, G. V. Matyushin, T. N. Mitroshina, G. I. Nechaeva, I. I. Reznik, V. V. Skibitsky, L. A. Sokolova, A. I. Chesnikova, N. V. Dobrynina, S. S. Yakushin

“…These patients also had lower QoL “Disease Perception” score and more confidence in the doctor (“Treatment Satisfaction” score) than non-adherent patients (p<0.05). …”
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The relationship and interinfluence of aspects of therapy safety and compliance in patients with cardiovascular diseases (by the data from outpatient registry “PROFILE”) by Yu. V. Lukina, N. A. Dmitrieva, N. P. Kutishenko, N. V. Kiseleva, S. Yu. Martsevich

“…Regular visits to the attending physician and informing the patient by the doctor, including about AE, significantly increased overall compliance (p<0,05). …”
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TRUST Study: Participation in Randomized Controlled Trials and Subsequent Adherence to Visiting Medical Institutions and Taking Medications in Patients with Cardiovascular Diseases... by N. O. Vasyukova, N. P. Kutishenko, Yu. V. Lukina, O. I. Zvonareva, S. Yu. Martsevich

“…Based on the data of the TRUST study (Influence of Participation in Randomized Controlled Trials on adheRence to Medicines' Intake and regUlar viSits to the docTor) to assess the quality of drug therapy and patients' awareness of achieving target blood counts and blood pressure (BP) among patients with coronary artery disease (CAD), diabetes mellitus (DM), hypertension.Material and methods. 102 patients are enrolled in the study group of the TRUST study who participated in one or more randomized clinical trials (RCT) in the period from 2011 to 2018. …”
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STUDY OF THE PARAMETERS OF TOLERABILITY AND ADHERENCE TO THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION ON THE BACKGROUND OF TREATMENT WIT... by S. Y. Martsevich, Yu. V. Lukina, N. P. Kutishenko, V. P. Voronina, N. A. Dmitrieva, A. V. Zakharova, O. V. Lerman, A. A. Garganeyeva, T. A. Gomova, S. A. Drozdetsky, A. I. Chesnikova

“…Regular patient visits to the doctor and the rapid achievement of an antihypertensive effect with good tolerability of a fixed combination of ramipril and amlodipine contributed to the increase in adherence of patients to treatment. …”
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Adherence to Statins Therapy of High and Very High Cardiovascular Risk Patients in Real Clinical Practice: Diagnostics and Possible Ways to Solve the Problem (According to the PRIO... by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, N. A. Dmitrieva, S. V. Blagodatskikh, O. V. Lerman, T. A. Gomova, S. I. Drozdetsky, V. V. Skibitskiy, E. A. Kudryashov, N. F. Puchinyan

“…To study adherence to treatment with generic statins prescribed to patients with high and very high cardiovascular risk in routine clinical practice, as well as the possible impact of educational training of doctors on compliance with clinical guidelines and changes in patient adherence to treatment. …”
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Evaluating Adherence to Medical Therapy in Patients with Chronic Heart Failure: Design and First Results of the COMPLIANCE Study by S. Yu. Martsevich, E. T. Guseynova, N. P. Kutishenko, Yu. V. Lukina, S. N. Tolpygina, V. P. Voronina, S. V. Blagodatskih

“…To study the adherence of doctors to the guidelines for the treatment of chronic heart failure (СHF) and the adherence of patients with СHF to the therapy prescribed by doctors.Material and methods. …”
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Challenges of Statin Therapy in Clinical Practice (According to Outpatient Register «PROFILE» Data) by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, A. V. Zagrebelnyy, S. N. Tolpygina, V. P. Voronina, N. A. Dmitrieva, O. V. Lerman, E. S. Nekoshnova, I. V. Budaeva, S. V. Blagodatskikh, B. B. Aslanova

“…The main problems of statin treatment in real clinical practice remain the non-assignment of these drugs to patients who have indications for such therapy and the failure to achieve the target levels of lipidogram indicators, which may probably be due to the clinical inertia of doctors regarding titration of statin doses, and in some cases caused by the choice of drugs that are not the most effective in reducing LDL cholesterol. …”
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Adherence to Treatment with New Oral Anticoagulants in Atrial Fibrillation Patients in Real Clinical Practice (Results of the ANTEY Study) by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, S. N. Tolpygina, V. P. Voronina, N. A. Dmitrieva, O. V. Lerman, N. A. Komkova

“…During V1 based on the results of the NSEPh adherence scale 155 (77.5%) patients were completely adherent (strictly followed doctors’ recommendations), 5 patients were partially adherent (violated doctors’ recommendations), 7 patients were partially non-adherent (stopped taking NOACs), and 33 patients were completely non-adherent (did not start taking NOACs). …”
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Main factors of adherence to new oral anticoagulants and its dynamics in outpatients with nonvalvular atrial fibrillation: results of the ANTEY study by Yu. V. Lukina, N. P. Kutishenko, S. N. Tolpygina, V. P. Voronina, N. A. Dmitrieva, O. V. Lerman, N. A. Komkova, A. V. Zagrebelny, S. Yu. Martsevich, O. M. Drapkina

“…In V0, all patients were prescribed one of the NOACs. At V1 doctors could recommend warfarin or another NOAC to patients, who have refused taking prescribed NOAC. …”
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ASSESSMENT OF ADHERENCE TO TREATMENT AND FACTORS AFFECTING IT IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE DURING THERAPY WITH NICORANDIL by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, A. V. Akimova, V. P. Voronina, O. V. Lerman, O. V. Gaisenok, T. A. Gomova, A. V. Ezhov, A. D. Kuimov, R. A. Libis, G. V. Matyushin, T. N. Mitroshina, G. I. Nechaeva, I. I. Reznik, V. V. Skibitsky, L. A. Sokolova, A. I. Chesnikova, N. V. Dobrynina, S. S. Yakushin

“…Patients of the group 1 compared to the patients of group 3 did not visit the doctors more often or attended them only when necessary, violated the medical prescriptions for taking medications (p<0.05). …”
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CLINICAL PRACTICE OF BETA-BLOCKERS USAGE IN PATIENTS WITH CARDIOVASCULAR AND CHRONIC RESPIRATORY DISEASES. DATA OF OUTPATIENT REGISTRIES PROFILE AND RECVASA by S. Yu. Martsevich, N. A. Zakharova, N. P. Kutishenko, A. V. Zagrebelnyy, Yu. V. Lukina, M. M. Loukianov, A. N. Vorobyev, A. N. Kozminsky

“…In patients with CVD and BA, doctors in both registries try not to prescribe β-AB. …”
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