The role of endometrial B cells in normal endometrium and in benign female reproductive pathologies: a systematic review by Shen, M, O'Donnell, E, Leon, G, Zondervan, K, Granne, I, Et al.

“…SUMMARY ANSWER Endometrial B cells typically constitute less than 5% of total endometrial CD45+ lymphocytes, and no more than 2% of total cells in the normal endometrium, and while their relative abundance and phenotypes vary in benign gynaecological conditions current evidence is inconsistent. …”

No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis. by Luong, H, Nyholt, DR, Painter, J, Chapman, B, Kennedy, S, Treloar, SA, Zondervan, K, Montgomery, G

“…STUDY DESIGN, SIZE AND DURATION: This was a case-control study with a total of 11 206 subjects. The study was performed between February 2012 and July 2012. …”

Uterine fibroids and cardiovascular risk. by Uimari, O, Auvinen, J, Jokelainen, J, Puukka, K, Ruokonen, A, Järvelin, M, Piltonen, T, Keinänen-Kiukaanniemi, S, Zondervan, K, Järvelä, I, Ryynänen, M, Martikainen, H

“…<br/> MAIN RESULTS AND THE ROLE OF CHANCE: A total of 729 fibroid cases were identified, including 293 based on hospital discharge registries. …”

Association between endometriosis and the interleukin 1A (IL1A) locus. by Sapkota, Y, Low, S, Attia, J, Gordon, S, Henders, A, Holliday, E, MacGregor, S, Martin, N, McEvoy, M, Morris, A, Takahashi, A, Scott, R, Kubo, M, Zondervan, K, Montgomery, G, Nyholt, DR

“…We, and others, have conducted genome-wide association (GWA) studies for endometriosis, which identified a total of nine independent risk loci. Recently, two small Japanese studies reported eight SNPs (rs6542095, rs11677416, rs3783550, rs3783525, rs3783553, rs2856836, rs1304037 and rs17561) at the IL1A gene locus as suggestively associated with endometriosis risk. …”

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis by Uimari, O, Rahmioglu, N, Nyholt, D, Vincent, K, Missmer, S, Becker, C, Morris, A, Montgomery, G, Zondervan, K

“…MAP3K4 was also shown to be differentially expressed in eutopic endometrium between Stage A endometriosis cases and controls (P = 3.8 × 10−4), but not with Stage B disease (P = 0.26). A total of 14 pathways enriched with genetic endometriosis associations were identified (false discovery rate (FDR)-P &lt; 0.05). …”

Genome-wide genetic analyses highlight MAPK signalling in the pathogenesis of endometriosis by UImari, O, Rahmioglu, N, Nyholt, D, Vincent, K, Missmer, S, Becker, C, Morris, A, Montgomery, G, Zondervan, K

“…MAP3K4 was also shown to be differentially expressed in eutopic endometrium between Stage A endometriosis cases and controls (P = 3.8 × 10^−4), but not with Stage B disease (P = 0.26). A total of 14 pathways enriched with genetic endometriosis associations were identified (false discovery rate (FDR)-P &lt; 0.05). …”