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Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa
Published 2015“…The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal models and in patients with HCM.Hypothesis: Our hypothesis is that the high incidence of exercise-related death in HCM may be explained by an acute impairment of myocardial energetics. …”
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