The effect of isoliquiritigenin on the hERG potassium channel by Mujahid, M, Wang, T, Ellory, C, Wilkins, R, Ma, Y-L

Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols by Beattie, K, Bardenet, R, Louttit, J, Vandenberg, J, Hill, A, Gavaghan, D, De Boer, T, Mirams, G

“…Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. …”

Modelling effects of Sotalol on Action Potential morphology using a novel Markov model of the HERG channel by Brennan, T, Fink, M, Rodriguez, B, Tarassenko, LT

HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance by Bueno−Orovio, A, Orini, M, Hanson, B, Hayward, M, Taggart, P, Lambiase, P, Burrage, K, Rodriguez, B

A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B