DEVELOPMENT AND CHARACTERISATION OF A NOVEL KNOCK-IN MODEL OF PRKAG2 CARDIOMYOPATHY by Yavari, A, Pinter, K, Ashrafian, H, Redwood, C, Watkins, H

The effect of combustion knock on the instantaneous heat flux in spark ignition engines by Stone, C, Mutzke, J, Williams, J, Scott, B

Utrophin luciferase knock-in mouse model for in vivo assessment of drug efficacy in preclinical trials for utrophin upregulation by Fairclough, R, Davies, K

AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells by Tolmachova, T, Tolmachov, O, Barnard, A, Groppe, M, During, M, MacLaren, R, Seabra, M

Glomerular protein sieving and implications for renal failure in Fanconi syndrome. by Norden, A, Lapsley, M, Lee, P, Pusey, C, Scheinman, S, Tam, F, Thakker, R, Unwin, R, Wrong, O

“…We have studied the proteinuria of Fanconi syndrome, a "knock-out" of renal tubular protein reabsorption, to estimate GSCs and detect potential contributors to development of renal failure. …”

Immune effector mechanisms in malaria. by Marsh, K, Kinyanjui, S

“…Tackling the methodological issues of defining protection and immune response, together with studies that combine functional assays with new approaches such as allelic exchange and gene knock out offer opportunities for better defining key targets and mechanisms.…”

Old Spanish resultatives as low depictives by Acedo-Matellan, V, Real-Puigdollers, C, Ausensi, J, Fontana, J-M

“…John shot him dead): Old Sp. lo abatió a tierra muerto, lit. ‘they knocked him down dead’. The alleged existence of adjectival resultative constructions in Old Romance varieties is puzzling, since they are absent in earlier varieties (Latin) or Modern Romance varieties. …”

Threats to journalists from the consumer Internet of Things by Shere, ARK, Nurse, JRC, Martin, A

“…These issues may have knock-on effects on societal stability and democratic processes if press freedom is eroded. …”

Isolated low temperature heat release in spark ignition engines by White, S, Bajwa, A, Leach, F

“…Low temperature heat release (LTHR) has been of interest to researchers for its potential to mitigate knock in spark ignition (SI) engines and control auto-ignition in advanced compression ignition (ACI) engines. …”

Cycle-to-cycle variation analysis of two-colour PLIF temperature measurements calibrated with laser induced grating spectroscopy in a firing GDI engine by Willman, C, Stone, R, Davy, M, Williams, B, Ewart, P, Shen, L, Hung, D, Liu, M, Camm, J

“…In-cylinder temperatures and their cyclic variations strongly influence many aspects of internal combustion engine operation, from chemical reaction rates determining the production of NOx and particulate matter to the tendency for auto-ignition leading to knock in spark ignition engines. Spatially resolved measurements of temperature can provide insights into such processes and enable validation of Computational Fluid Dynamics simulations used to model engine performance and guide engine design. …”

Hyaluronan derived from the limbus is a key Regulator of Corneal Lymphangiogenesis by Sun, M, Puri, S, Mutoji, KN, Coulson-Thomas, YM, Hascall, V, Jackson, DG, Gesteira, TF, Coulson-Thomas, VJ

“…<br><br> Methods: <br>Wild-type (wt) and hyaluronan synthase (HAS) knockout mice - specifically combined Has1-/- and Has3 -/- null mice (HAS1-/-;HAS3-/-) and conditional Has2 knock-out mice (HAS2D/DCorEpi), were used. The mice were subjected to injury, alkali burn or suture placement, to investigate the role of HA on corneal lymphangiogenesis. …”

Evaluation of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man by Reilly, S, Liu, X, Carnicer, R, Rajakumar, T, Sayeed, R, Krasopoulos, G, Verheule, S, Fulga, T, Schotten, U, Casadei, B

“…We also used a goat model of pacing-induced atrial fibrillation (24 with atrial fibrillation vs 20 controls in normal sinus rythm) and nNos-knock-out mice (n=28 compared with 27 wild-type littermates). …”