Repressed chromatin drives leukaemogenesis in mutant IDH2 acute myeloid leukaemia via inhibition of granulocyte differentiation and cell cycle progression by Silveira, DRA, Chatzikyriakou, P, Yavorska, O, Mackie, S, Hulks, R, Siejka-Zielinska, P, Corby, A, Smith, A, Brown, B, Metzner, M, Milne, TA, Penard-Lacronique, V, Song, C, Hasan, M, Thakurta, A, Vyas, P, Kriaucionis, S, Quek, L

“…American Society of Hematology…”

A phase 2, open-label, multiarm, multicenter study to evaluate magrolimab combined with antileukemia therapies for first-line, relapsed/refractory, or maintenance treatment of acut... by Vyas, P, Daver, N, Chao, M, Xing, G, Renard, C, Ramsingh, G, Wei, AH, Sallman, DA

“…American Society of Hematology…”

Expression of the human alpha-globin cluster in the absence of the major regulatory element Mcs-R2 by Badat, M, Davies, JOJ, Van Beers, EJ, Harteveld, C, Downes, D, Higgs, DR

“…American Society of Hematology…”

Outcomes for patients with late-stage mutant-IDH2 (m IDH2) relapsed/refractory acute myeloid leukemia (R/R AML) treated with enasidenib vs other lower-intensity therapies in the ra... by DiNardo, CD, Montesinos, P, Schuh, AC, Papayannidis, C, Vyas, P, Wei, AH, Zeidan, AM, Bluemmert, I, Yu, X, Hasan, M, Martin-Regueira, P, de Botton, S

“…American Society of Hematology…”

Characterization of factors determining the kinetics of disease relapse after allogeneic Stem Cell Transplantation (allo-SCT) or chemotherapeutic consolidation for Acute Myeloid Le... by Craddock, C, Versluis, J, Labopin, M, Socie, G, Huyn, A, Deconinck, E, Volin, L, Milpied, N, Bourhis, JH, Rambaldi, A, Chevallier, P, Blaise, D, Markus, M, Vellenga, E, Vekemans, MC, Maertens, J, Passweg, JR, Schmid, C, Ossenkoppele, GJ, Vyas, P, Löwenberg, B, Mohty, M, Cornelissen, JJ, Nagler, A

“…American Society of Hematology…”

Outcomes of relapsed/refractory patients with IDH1/2 mutated AML treated with non-targeted therapy: results from the NCRI AML trials by Hills, R, Gale, R, Linch, D, Huntly, B, Papaemmanuil, E, Vyas, P, Burnett, A, Russell, N

“…American Society of Hematology…”

Trisomy 21 driven pro-inflammatory signalling in fetal bone marrow may play a role in perturbed B-lymphopoiesis and acute lymphoblastic leukemia of Down syndrome by O'Byrne, SI, Elliott, N, Buck, G, Rice, S, O'Connor, D, Oswald, J, Fuchs, H, Labbett, E-M, Fordham, NJ, Roy, A, Roberts, I

“…American Society of Hematology…”

Modelling the progression of a preleukemic stage to overt leukemia in children with down syndrome by Labuhn, M, Perkins, K, Papaemmanuil, E, Garnett, C, Matzk, S, Amstislavskiy, V, Metzner, M, Kennedy, A, Scheer, C, Yoshida, K, Schwarzer, A, Crispino, J, Taub, J, Weiss, M, Ito, E, Ogawa, S, Reinhardt, D, Yaspo, M, Campbell, P, Heckl, D, Klusmann, J, Vyas, P

“…American Society of Hematology…”

Vorinostat does not improve outcome in patients with acute myeloid leukemia and high risk myelodysplasia treated with azacitidine: Results of the UK Trials Acceleration Programme R... by Craddock, C, Houlton, A, Ferguson, P, Raghavan, M, Fox, S, Dudley, L, Quek, L, Cavenagh, J, Dennis, M, McMullin, M, Pillai, S, Kelly, R, Siddique, S, Wheatley, K, Vyas, P

“…American Society of Hematology…”

Health-related quality of life (HRQoL) during treatment with enasidenib (ENA) plus azacitidine (AZA) in patients with newly diagnosed mutant IDH2 (m IDH2) acute myeloid leukemia (A... by DiNardo, CD, Dohner, H, Zeidan, AM, Schuh, AC, Vyas, P, Stein, EM, Wei, AH, de Botton, S, Chen, C, Lord-Bessen, J, Martin-Regueira, P, Lersch, F, Gong, J, Guo, S, Shi, L, Montesinos, P

“…American Society of Hematology…”

A novel model of human hemopoiesis based on single cell functional and transcriptional analysis of lympho-myeloid progenitors by Stoilova, B, Karamitros, D, Aboukhalil, Z, Hamey, F, Reinisch, A, Samitsch, M, Quek, L, Otto, G, Repapi, E, Doondeea, J, Usukhbayar, B, Calvo, J, Taylor, S, Goardon, N, Six, E, Pflumio, F, Porcher, C, Majeti, R, Gottgens, B, Vyas, P

“…American Society of Hematology…”

Role of PD-1/PD-L1 in acute and chronic graft versus host disease by Blazar, B, O'Connor, R, Milone, M, Dustin, M, Riley, J, Vincent, B, Serody, J, Flynn, R, Paz, K, Du, J, Panoskaltsis-Mortari, A, Jeffrey, M, Ahmed, R, Turka, L, Freeman, G, Sharpe, A, Saha, A

“…American Society of Hematology…”

Is sepsis a risk factor for bleeding in adults with hematologic malignancies? by Estcourt, L, Hudson, C, Stanworth, S

“…American Society of Hematology…”

Niche heterogeneity impacts evolution of myeloproliferative neoplasms driven by the same oncogenic pathway by Korn, C, Rak, J, Garcia-Garcia, A, Fielding, C, Khorshed, R, Gonzalez-Anton, S, Li, J, Norfo, R, Baxter, E, McKerrell, T, Roberts, T, Eldaly, H, Godfrey, A, Castillo-Venzor, A, Kusumbe, A, Mead, A, Green, A, Kent, D, Lo Celso, C, Mendez-Ferrer, S

“…American Society of Hematology…”

Azacitidine with or without eltrombopag for first-line treatment of intermediate- or high-risk MDS with thrombocytopenia by Dickinson, M, Cherif, H, Fenaux, P, Mittelman, M, Verma, A, Portella, M, Burgess, P, Ramos, P, Choi, J, Platzbecker, U, Support Study Investigators

“…American Society of Hematology…”

Longitudinal mutational analysis in hydroxycarbamide-resistant/intolerant essential thrombocythemia treated on the majic-ET study by O'Sullivan, J, Hamblin, A, Panchal, A, Yap, C, Fox, S, Alimam, S, Dreau, H, Howard, K, Ware, P, Baker, S, Cross, N, McMullin, M, Harrison, C, Mead, A

“…American Society of Hematology…”

Single Cell Analysis of Acquired Pomalidomide-Resistance in Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations and Gene Expression Heterogeneity by Gooding, S, Bjorklund, C, Amatangelo, M, Ren, Y, Marella, M, Couto, S, Park, C, Lata, S, Nibhani, R, Towfic, F, Oppermann, U, Ramasamy, K, Pierceall, W, Vyas, P, Thakurta, A

“…American Society of Hematology…”

Correlation between treatment outcomes, baseline characteristics and molecular responses in the Majic study which compared Ruxolitinib to best available therapy in essential thromb... by Harrison, C, Mead, A, Fox, S, Panchal, A, Yap, C, Houlton, A, Aliman, S, Ewing, J, Wood, M, Chen, F, Coppell, J, Panoskaltsis, N, Knapper, S, Ali, S, Hamblin, A, Scherber, R, Geyer, H, Scotch, A, Dueck, A, Cross, N, Mesa, R, McMullin, M

“…American Society of Hematology…”

A single-cell approach to unraveling abnormal megakaryocyte differentiation and function in myelofibrosis by Psaila, B, Heuston, E, Milojkovic, D, Lichtenberg, J, Anderson, S, Hoffman, R, Roberts, I, Mead, A, Bodine, D, Barkas, N, Progra, N

“…American Society of Hematology…”

Protein kinase C-theta interacts with mTORC2 and vimentin to limit regulatory T-cell function by McDonald-Hyman, C, Thangavelu, G, Muller, J, Zhang, G, Kumari, S, Saha, A, Koehn, B, Mitchell, J, Fife, B, Serody, J, Osborn, M, Hippen, K, Kelekar, A, Munn, D, Altman, A, Neubert, T, Dustin, M, Blazar, B

“…American Society of Hematology…”