Molecular characterization of avian immunosuppressive viral diseases by Omar, Abdul Rahman, Ideris, Aini, Bejo, Mohd Hair, Jamaluddin, A. A., S. H., Sharifah, Yusoff, Khatijah, Darus, A., Kono, Y.

Subjects: “…Immunosuppressive agents.…”
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Induction of immunosuppression by benzo (a) pyrene in broilers by Saulol Hamid, Nur Fazila, Mohamed Mustapha, Noordin

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Immunosuppressive effects of benzo (a) pyrene on Newcastle disease vaccination in broilers by Ahmad Zabidi, Norameza, Mohamed Mustapha, Noordin

“…Newcastle disease (ND) vaccination was used as a model in assessing the role of benzo(a)pyrene (BaP) in inducing immunosuppression. Forty day-old chicks were divided into a control and BaP group comprising of 20 birds each. …”
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Infection with very virulent infectious bursal disease virus causes infiltration of t cells into bursa of fabricius by Jamil, Aimi Zulfadli, Swee, Keong Yeap, Omar, Abdul Rahman, Mohammed Alitheen, Norjahan Banu

“…Infectious bursal disease (IBD) is an immunosuppression disease, causing high mortality rate in young chickens and instigated by Infectious Bursal Disease Virus (IBDV). …”
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Reversible posterior leukoencephalopathy syndrome in post streptococcal glomerulonephritis by Yubbu, Putri, Abd Hamid, Mohd Zaini, Jamaluddin, Johan Aref, Kee, Sze Ying, Mohd Fakharuddin, Mohd Feizel Alsiddiq, Othman, Norlijah, Ting, Tzer Hwu

“…This syndrome commonly associated with hypertension, ecclampsia, renal failure or the used of some immunosuppression medications especially cyclosporine and tacrolimus. …”
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Immunotoxicity of pyrene and phenanthrene in embryonated chicken eggs by Koh, Ee Zhan, Mohamed Mustapha, Noordin

“…Many PAHs are highly toxic, teratogenic, mutagenic, carcinogenic and immunosuppressive to animals and humans. However, toxicity data for pyrene (Py) and phenanthrene (Ph) are still limited especially for the concerns of the poultry industry. …”
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Computational approach in predicting infectious bursal disease virus (IBDV) epitopes by Awang Keri, Awang Ilham, Mat Isa, Nurulfiza, Omar, Abdul Rahman, Bejo, Mohd Hair

“…Infectious bursal disease (IBD) causes immunosuppression and mortality in chickens from 3- 6 weeks of age. …”
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Transcriptomic analysis on susceptibility of different inbred chicken lines towards very virulent infectious bursal disease virus infection by Mohd Isa, Noor Farhanah, Bejo, Mohd Hair, Mat Isa, Nurulfiza, Ideris, Aini, Nair, Venugopal, Omar, Abdul Rahman

“…The virus is a causative agent for Gumboro disease which can cause high mortality rate in young chickens by infecting and destroying actively dividing IgM-bearing B lymphocytes in the bursa of Fabricius leading to immunosuppression. Previous studies have identified differential expression of immune-mediated genes related to inflammatory response in chickens with different genetic susceptibility to IBDV infections. …”
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The effects of dietary supplementation of methanolic extracts of herbal medicine on haematological variable of red hybrid tilapia (Oreochromis sp.) by Manaf, Sharifah Raina, Mohd Daud, Hassan, Mohamed Mustapha, Noordin, Alimon, Abdul Razak, Hamdan, Ruhil Hayati, Mohamad, Nora Faten Afifah, Hamid, N. H., Muniandy, Kumari Geetha, A. R., Rashidah

“…The most common strategy to treat in aquaculture disease is the use of antibiotics, however, such utilization has been accounted to have antagonistic impacts like accumulation of drugs in tissues, development of drug resistance and immunosuppression. One of the most promising methods of controlling diseases in aquaculture is strengthening the defence mechanisms through therapeutic administration. …”
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Maintenance of virulence markers in the UPM 93273 IBDV isolate after 48 passages in SPF embryonated chicken eggs by Hashim, Thuzar Than @ Hafiza, Ideris, Aini, Omar, Abdul Rahman

“…Infectious bursal disease virus (IBDV) is highly contagious and immunosuppressive in chickens. Virus neutralizing epitopes reside in the VP2 hypervariable region (hv) which harbor the most characteristic markers of virulence. …”
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Immunoregulatory response following benzo-a-pyrene instillation in embryonated chicken eggs by Roslan, Amar, Mohamed Mustapha, Noordin

“…Although being reported as mutagenic, carcinogenic and immunosuppressive in chickens, its in ovo effect has not been documented. …”
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Bursal transcriptome of different inbred chicken lines following infection with very virulent infectious bursal disease virus by Mohd Isa, Noor Farhanah, Bejo, Mohd Hair, Mat Isa, Nurulfiza, Ideris, Aini, Nair, Venugopal, Omar, Abdul Rahman

“…Infectious bursal disease virus (IBDV) targeting IgM-bearing B cells in the bursa of fabricius cause an immunosuppressive effect in young chickens. Infection with IBDV evoked necessary immune response such as infiltration of T cell and macrophages into the bursa which may limit viral replication or promote bursal tissue damage through cytokine secretion. …”
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Infectivity of CD4+ T cells and CD8+ T cells against IBDV in chicken by Teoh, Siak Mun, Tan, S. W., Ideris, Aini, Omar, Abdul Rahman

“…Infectious bursal disease virus (IBDV) is a viral immunosuppressive disease found in chickens chickens, targeting mainly the Bursa of Fabricious, a major lymphoid organ in flocks. …”
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Characterisation on the role of non B lymphocytes during infectious bursal disease virus infection. by Omar, Abdul Rahman, Rasoli, Mehdi, Moeini, Hassan, Swee, Keong Yeap, Kaiser, Pete, Bejo, Mohd Hair, Ideris, Aini, Sheau, Wei Tan

“…Hence, the disease been considered to have the most impact due to its immunosuppressive effects in young birds. However, the effects of the virus on non B lymphocytes are poorly characterised. …”
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Deciphering the anti-tumour activity of human mesenchymal stem cells on haematopoietic tumour cell lines by Ramasamy, Rajesh

“…The recent development in mesenchymal stem cell research promises a new anti-cancer therapy via a possible mode of cell cycle arrest, apoptosis and immunosuppressive activity. The present study aims to investigate the inhibitory activity of UC-MSCs on tumour cells’ (HL-60, K562, Jurkat and BV173 cell lines) proliferation at in vitro by elucidating the signalling mechanisms and the relevant gene expression profiles. …”
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Challenges in controlling viral diseases of poultry by Omar, Abdul Rahman

“…In many situations, immunosuppressive agents primarily MDV, IBDV, and chicken anemia virus play an important role in increasing the susceptibility of chickens to opportunistic infections and/or suppressing effective vaccine induced responses.There is no doubt diagnostic tools, vaccines and vaccination equipment have improved over the years. …”
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