BK virus immunity in patients undergoing hematopoietic stem cell transplant. by Teo, Ai Ling.

“…Hematopoietic stem cell transplant (HSCT) is an important modality of treatment for hematological diseases and cancers. …”
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Designing calcium alginate for ex vivo expansion of hematopoietic stem cells. by Lim, Carine Zhi Jun.

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Core-shell microencapsulation of hematopoietic stem cells for the optimisation of lentiviral gene delivery using microfluidics by Sun, Qinglu

“…This project employed an aqueous two-phase system and double-emulsion method (water-in-water-in-oil) to synthesize microcapsules for encapsulation of hematopoietic stem cells (HSCs) and lentivirus (LVs) with a custom-made microfluidic platform, and the synthesis process was optimized. …”
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Effects of micro and nanotopography on hematopoietic cell fate decision by Lim, Kuan Chien.

“…The lack of an appropriate in vitro model is currently one of the major bottlenecks in studying hematopoietic stem cell behaviors. In vivo, hematopoietic cells reside in the bone marrow niche where a wealth of microenvironmental information comprising biochemical and biophysical topographical cues at the micro and nanoscale level provide extrinsic biosignals to initiate major intracellular signaling pathways which are implicated in directing the hematopoietic cell fate decision. …”
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Material characterization of ca-alginate hydrogel by Nabilah Mashhur Ali

“…Recently in our lab, we have shown that it is able to support proliferation of encapsulated hematopoietic stem cells in-vitro. To better understand and control the impact of biophysical cues provided by alginate hydrogels, we performed mechanical and structural characterization of Ca-alginate hydrogels in varying chemical compositions. …”
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Effect of recombinant Wnt protein on the Ex vivo expansion of umbilical cord blood hematopoietic cells. by Lim, Shy Ni.

“…Wnt gene pathway has shown to play an important role in the maintenance and development of hematopoietic stem cells (HSCs) compartment. The low number of HSCs in each umbilical cord blood (UCB) unit has limited its use in transplantation for adult patients. …”
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Engineering a vascularized bone tissue construct via transgenic angiogenic induction by Chen, Siang Yee

“…Stromal cell-derived factor 1á (SDF-1á) serves as chemoattractant that direct the migration of stem cells such as hematopoietic stem cells and mesenchymal stem cells (MSCs) to the injury site, where the level of SDF-1á is increased. …”
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Bone marrow on-a-chip for one step recruitment and expansion of leukemic stem cells by Oo, Nwe Nwe Linn

“…The interactions between the bone marrow (BM) niche and hematopoietic stem cells (HSC) are known to be important for the recruitment, expansion and maintenance of the HSCs. …”
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Exploring the utility of multivariate analysis for cell culture process development by Neo, Kai Xian

“…The therapeutic use of hematopoietic stem cells (HSCs) in clinical applications is hindered by insufficient number of donor cells. …”
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Transgenic viral vector mediated delivery of stromal cell-derived factor 1α and suprresion of type I collagen by RNA interference for enhanced tissue regeneration by Fang, Yu

“…By investigating blood and implant cell samples with fluorescence-activated cell sorting (FACS) for CXCR (SDF-1α receptor) positive cells, the hematopoietic stem cells and mesenchymal stem cells were observed to migrate against the gradient to the LS transplantation site. …”
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