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1
Engineering nucleic acid constructs for lymphoma therapy
Published 2024“…Interestingly, unlike normal cancer cells, Natural killer/T cell lymphoma (NKTL) does not express phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of DNSS. …”
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Final Year Project (FYP) -
2
Novel therapeutic approach for cutaneous T-Cell lymphoma
Published 2016“…Cutaneous T-cell lymphoma (CTCL) is a skin-localizing, non-Hodgkin lymphoma arising from the malignant transformation of skin-homing CD4+ T-cells. …”
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Final Year Project (FYP) -
3
Modulators of rituximab-induced complement-dependent cytotoxicity in diffuse large B-cell lymphoma
Published 2021“…Rituximab, the chimeric monoclonal antibody targeting CD20, forms the cornerstone of therapy for diffuse large B-cell lymphoma (DLBCL). However, more than one-third of patients eventually become unresponsive or resistant to rituximab. …”
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Final Year Project (FYP) -
4
Modulation of immunogenicity and Epstein-Barr virus gene expression in lymphomas with small-molecule inhibitors
Published 2023“…Natural killer/T-cell lymphoma (NKTL) is an Epstein-Barr virus (EBV)-associated lymphoproliferative disorder characterized by poor clinical outcomes. …”
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Final Year Project (FYP) -
5
Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
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Final Year Project (FYP) -
6
Anticancer activities of novel hyper-charged antimicrobial peptides
Published 2018“…This study aims to screen a panel of hyper-charged (HC) AMPs with anti-proliferative activity and investigate the molecular mechanism in cutaneous T-cell lymphoma (CTCL), a non-Hodgkin lymphoma that is a leading cause of morbidity and mortality. …”
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Final Year Project (FYP) -
7
Elucidating mechanisms underlying cancer cell regulation of serine synthesis
Published 2024“…Natural killer/T-cell lymphoma (NKTL) is a highly aggressive form of Epstein-Barr virus (EBV) associated non-Hodgkin lymphoma (NHL) with dismal treatment outcomes observed in advanced stages. …”
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Final Year Project (FYP) -
8
130912
Published 2014“…130912 is a reflection of the artist’s intimate collection of thoughts and memories of her late husband who was diagnosed with Hodgkin’s Lymphoma on 13 September 2012. Through a series of ritualistic site specific performances dealing with a polar opposite – preservation and destruction – the artist stages scenes that allow her to explore her loss. …”
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Final Year Project (FYP) -
9
Activation and regulation of IL-1β family of cytokines by EV71 infection
Published 2014“…In this study, we first tested the ability of EV71 (BrCr and WD strain) in infecting differentiated monocyte lymphoma (U937) cells, epithelial lung cancer (A549) cells and liver cancer (HUH7) cells. …”
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Final Year Project (FYP) -
10
Using CRISPR/Cas9 approaches to interrogate and delineate viral gene expression programmes
Published 2023“…Natural Killer/T cell Lymphoma (NKTL) is a highly aggressive form of nasopharyngeal cancer highly correlated with Epstein-Barr Virus (EBV) infection with poor treatment outcomes. …”
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Final Year Project (FYP) -
11
Regulation of Epstein-Barr virus gene expression via CRISPR-mediated targeting of DNA methylation enzymes
Published 2024“…Globally, EBV drives a number of human cancers, including Natural Killer/T cell Lymphoma (NKTL). NKTL is an aggressive malignancy thought to express a limited number of EBV proteins, namely EBV nuclear antigen 1 (EBNA1) and latent membrane proteins (LMPs) 1 and 2. …”
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Final Year Project (FYP) -
12
Retrospective survey of cardiac tumours diagnosed in a tertiary centre in Singapore over a 12 year period.
Published 2009“…Malignant tumours involving the heart included 2 lymphomas, 1 renal cell carcinoma, 1 sarcoma, 1 hepatocellular carcinoma and 1 liposarcoma. …”
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Final Year Project (FYP)