Bioinformatics investigations on multi-omics datasets of neurodegeneration by Lim, Jolyn Jia Jia

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Modulation of sphingolipids, cholesterol and saturated fatty acids interact with the neurodegeneration in the Drosophila blue cheese mutant. by Boo, George.

“…To elucidate the association between aberrant metabolism of lipids and age-related neurodegeneration, we study the Drosophila neurodegenerative blue cheese (bchs) mutant. bchs is associated with lysosomal trafficking and autophagosomal degradation of aggregated proteins. …”
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Effects on diet-induced autophagy in metazoa by Fun, Xiu Hui

“…This study aims to determine the effects of high fat and sugar diets on neurodegeneration and lipid composition in a genetic mutant model affecting autophagy in Drosophila. …”
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Effects of angular guidance in shaping neuronal polarity and neurites growth direction by Chong, Swee Tong

“…Neurodegeneration can result from the loss of neuronal polarity, the loss of neurite directionality or even the breakdown of neuronal networks. …”
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Genetic programs of neuronal degeneration in dendrite arborisation neurons. by Lee, Hui Min.

“…The identification of genes involved in dendrite pruning aided our understanding of the molecular mechanism of neurodegeneration as well as proving that RNAi can be an efficient way to identify novel genes involved in dendrite pruning.…”
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Reviewing the role of protein misfolding and aggregation in neurodegenerative diseases by Ren, Qunfang

“…It is now widely accepted that these aggregates are involved in pathogenesis of neurodegeneration. Each neurodegenerative disease is associated with a disease protein that folds wrongly and form large aggregates. …”
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Functional food and autophagy. by Sim, Zhi Wei.

“…Diet has also been intimately linked to diseases like neurodegeneration and cancers. In this study, we are interested to explore the potential of influencing the progression of human diseases by modulating of autophagy through functional. …”
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Genome-wide studies of neuronal degeneration in dendrite arborization neurons. by Toh, Jia Yi.

“…Neuronal pruning is a widely observed phenomenon important for the development and refinement of neural circuits to ensure precise and functional connections. Developmental neurodegeneration, a process common to both mammals and Drosophila melanogaster resembles neuronal degeneration in states of neuronal injury and neuronal disorder morphologically. …”
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Studying the role of protein deamidation in neurodegenerative disease in proteome-wide scale by Ang, Yi Lin

“…Therefore, to elucidate the association and impact of deamidated proteins in neurodegeneration, and to minimize nonenzymatic deamidation during sample preparation, this work focused on developing protocol for enriching membrane and insoluble proteins. …”
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Investigating the effect of stress on a mouse model for Parkinson’s disease by Yeo, Natalie

“…With chronic stress known to aggravate dopaminergic neurodegeneration and motor dysfunction in PD rodent models, we aimed to study the effects of stress on the LRRK2 (R1441G) mouse model of PD. …”
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Biochemical characterisation of Larkinella arboricola (LA) Toll/Interleukin-1 receptor (TIR) domain-containing protein stimulator of interferon genes (STING) (TIR-STING) domain by Koh, Daryl Qian Hao

“…Many STING signalling trafficking illnesses appear to have an influence on the central nervous system, resulting in neurodegeneration. As a result, STING trafficking adds a new dimension to immunological signalling, which may have far-reaching repercussions in human illness. …”
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White matter connectivity for detection of Alzheimer's disease by Huang, Dajing

“…Alzheimer’s disease (AD) is the most common type of dementia, characterized by progressive neurodegeneration and cognitive impairment. Patients typically experience progressive loss of cognitive abilities which eventually becomes serious enough to interfere with one’s daily life. …”
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