Probing the interior environment of carbon nano-test-tubes by Watt, AAR, Sambrook, MR, Burlakov, SV, Porfyrakis, K, Briggs, GAD

“…High resolution transmission electron microscopy (HRTEM), optical absorption and electron spin resonance (ESR) are used to determine the rotational behavior of the encapsulated molecules and determine the polar nature of the nanotube interior.…”

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease by Fowler, SL, Behr, TS, Turkes, E, Cauhy, PM, Foiani, MS, Schaler, A, Crowley, G, Bez, S, Ficulle, E, Tsefou, E, O'Brien, DP, Fischer, R, Geary, B, Gaur, P, Miller, C, D'Acunzo, P, Levy, E, Duff, KE, Ryskeldi-Falcon, B

“…Here, we combined quantitative mass spectrometry, cryo-electron tomography and single-particle cryo-electron microscopy to study brain EVs from AD patients. …”

Myosin-5 varies its steps along the irregular F-actin track by Fineberg, A, Takagi, Y, Thirumurugan, K, Andrecka, J, Billington, N, Young, G, Cole, D, Burgess, SA, Curd, AP, Hammer, JA, Sellers, JR, Kukura, P, Knight, PJ

“…We show that cumulative angular disorder in F-actin accounts for the observed proportion of each stride length, akin to crossing a river on variably-spaced stepping stones. Electron microscopy revealed the structure of the stepping molecule. …”

Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC by Dietz, L, Ellison, CJ, Riechmann, C, Cassidy, CK, Felfoldi, FD, Pinto-Fernández, A, Kessler, BM, Elliott, PR

“…Importantly, we show SMAC supresses both mechanisms. Cryo-electron microscopy (cryo-EM) structures of BIRC6 alone and in complex with SMAC reveal BIRC6 exists as an anti-parallel dimer with a substrate-binding module juxtaposed to the catalytic domain at each end, and we identify multiple highly conserved unannotated domains important for architecture and function. …”