KL guided domain adaptation by Nguyen, AT, Tran, T, Gal, Y, Torr, PHS, Baydin, AG

Wisdom of the crowds or ignorance of the masses? A data-driven guide to WSB by Semenova, V, Gorduza, D, Wildi, W, Dong, X, Zohren, S

“…This paper presents a data-driven guide to the forum that started the hype – WallStreetBets (WSB). …”

Lesion Size Index (LSI)–guided catheter ablation for atrial fibrillation: can tissue impedance drop help to identify desirable ablation settings and target indices? by Leo, M, Banerjee, A, Gala, AB, Pope, M, Pedersen, M, Rajappan, K, Ginks, M, Bashir, Y, Hunter, RJ, Betts, T

“…</strong> When using Lesion Size index (LSI) to guide catheter ablation, it is unclear what combination of power, contact force and time would be preferable to use and what LSI target value to aim for. …”

Considering gender when promoting small-scale irrigation technologies (IFPRI-REACH Project note) by Theis, S, Deribe, RB, Lefore, N, Meinzen-Dick, R, Ringler, C

“…Many actors promoting irrigation technologies in low- and middle-income countries want to ensure that men, women, and different social groups have equal opportunity to participate in and benefit from irrigation but are uncertain how to do so. This tool provides a guide and structured set of questions to assess gender dynamics in irrigation in a specific context. …”

From data to decisions: Water quality monitoring programs in sub-Saharan Africa (Aquaya Research brief) by Aquaya

“…Most countries maintain regulatory requirements for testing of drinking water supplies to guide treatment procedures and ensure safe water delivery to consumers. …”

Sustaining safely managed drinking water services in rural schools in Chandpur District, Bangladesh (REACH Discussion brief) by REACH

“…Understanding and responding to variable usage and failure events will help to monitor infrastructure, improve management systems, and guide future planning and investment.</p>…”

From data to decisions: Water quality monitoring programs in Kenya (Aquaya Research brief) by Aquaya

“…Most countries maintain regulatory requirements for testing of drinking water supplies to guide treatment procedures and ensure safe water delivery to consumers. …”

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease by Fowler, SL, Behr, TS, Turkes, E, Cauhy, PM, Foiani, MS, Schaler, A, Crowley, G, Bez, S, Ficulle, E, Tsefou, E, O'Brien, DP, Fischer, R, Geary, B, Gaur, P, Miller, C, D'Acunzo, P, Levy, E, Duff, KE, Ryskeldi-Falcon, B

“…We observed multiple filament interactions, including with molecules that tethered filaments to the EV limiting membrane, suggesting selective packaging. Our findings will guide studies into the molecular mechanisms of EV-mediated secretion of assembled tau and inform the targeting of EV-associated tau as potential therapeutic and biomarker strategies for AD.…”

Improving water and hand-washing services in rural health care facilities in Kitui County, Kenya by Katuva, J, Hope, R, McBurney, E, Gladstone, N, Nyaga, C, Njung'e, D

“…This study draws upon a diagnostic survey of WASH in health care facilities in Kitui County, Kenya, in 2019, and a pilot intervention providing professional delivery of water and soap services to 11 rural dispensaries in 2020. Three objectives guide the work. First, to estimate the annualised cost of providing safe water and soap in dispensaries. …”

Genomics and insurance in the United Kingdom: Increasing complexity and emerging challenges by Dixon, P, Horton, RH, Newman, WG, McDermott, JH, Lucassen, A

“…We discuss three core issues: (1) As genomic testing advances, and results are increasingly relevant to guide healthcare across an individual's lifetime, the distinction between diagnostic and predictive testing that the current UK insurance code relies on becomes more blurred and this has consequences what constitutes a genetic “result” (2) The emerging category of pharmacogenomic tests which are predictive only the in the context of a specific prescribing moment (3) The increasing availability and affordability of polygenic scores that are neither clearly diagnostic nor highly predictive, but which nonetheless might have incremental value for insurance underwriting beyond conventional factors. …”

ABC easy as 123: a blind counter for exemplar-free multi-class class-agnostic counting by Hobley, MA, Prisacariu, VA

“…ABC123 introduces a new paradigm where instead of requiring exemplars to guide the enumeration, examples are found after the counting stage to help a user understand the generated outputs. …”

REACH Story of Change: Progress to deliver safe drinking water services to 100 million rural people by 2030 by REACH

“…Four conditions are proposed to guide prioritising on-going country engagement: a) policy alignment, b) public finance, c) verifiable data, and d) professional services. …”

Global disparities in SARS-CoV-2 genomic surveillance by Brito, AF, Semenova, E, Dudas, G, Hassler, GW, Kalinich, CC, Kraemer, MUG, Ho, J, Tegally, H, Githinji, G, Agoti, CN, Matkin, LE, Whittaker, C, Danish Covid-19 Genome Consortium, COVID-19 Impact Project, Network for Genomic Surveillance in South Africa (NGS-SA), GISAID core curation team, Howden, BP, Sintchenko, V, Zuckerman, NS, Mor, O, Blankenship, HM, de Oliveira, T, Lin, RTP, Siqueira, MM, Resende, PC, Vasconcelos, ATR, Spilki, FR, Aguiar, RS, Alexiev, I, Ivanov, IN, Philipova, I, Carrington, CVF, Sahadeo, NSD, Gurry, C, Maurer-Stroh, S, Naidoo, D, von Eije, KJ, Perkins, MD, van Kerkhove, M, Hill, SC, Sabino, EC, Pybus, OG, Dye, C, Bhatt, S, Flaxman, S, Suchard, MA, Grubaugh, ND, Baele, G, Faria, NR

“…Genomic sequencing provides critical information to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments and vaccines, and guide public health responses. To investigate the spatiotemporal heterogeneity in the global SARS-CoV-2 genomic surveillance, we estimated the impact of sequencing intensity and turnaround times (TAT) on variant detection in 167 countries. …”

Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration by Martinson, WD, McLennan, R, Teddy, JM, McKinney, MC, Davidson, LA, Baker, RE, Byrne, HM, Kulesa, PM, Maini, PK

“…ECM remodeling, haptotaxis, contact guidance, and cell-cell repulsion are sufficient for cells to establish streams in silico, however additional mechanisms, such as chemotaxis, are required to consistently guide cells along the correct target corridor. Further model investigations imply that contact guidance and differential cell-cell repulsion between leader and follower cells are key contributors to robust collective cell migration by preventing stream breakage. …”

Predicting “pain genes”: multi-modal data integration using probabilistic classifiers and interaction networks by Zhao, N, Bennett, DL, Baskozos, G, Barry, AM

“…These analyses can be further explored using the linked open-source database at https://livedataoxford.shinyapps.io/drg-directory/, which is accompanied by a freely accessible code template and user guide for wider adoption across disciplines. Together, the novel insights into pain pathogenesis can indicate promising directions for future experimental research.…”

Symptom-based case definitions for COVID-19: time and geographical variations for detection at hospital admission among 260,000 patients by ISARIC Clinical Characterisation Group, Baruch, J, Rojek, A, Kartsonaki, C, Vijayaraghavan, B, Gonçalves, B, Pritchard, M, Merson, L, Dunning, J, Sigfrid, L, Citarella, B, Murthy, S, Yeabah, T, Olliaro, P

“…Introduction: Case definitions are used to guide clinical practice, surveillance, and research protocols. …”

Large sSynoptic Survey Telescope Galaxies Science Roadmap by Robertson, BE, Banerji, M, Cooper, MC, Davies, R, Driver, SP, Ferguson, AMN, Ferguson, HC, Gawiser, E, Kaviraj, S, Knapen, JH, Lintott, C, Lotz, J, Newman, JA, Norman, DJ, Padilla, N, Schmidt, SJ, Smith, GP, Tyson, JA, Verma, A, Zehavi, I, Armus, L, Avestruz, C, Barrientos, LF, Bowler, RAA, Bremer, MN, Conselice, CJ, Davies, J, Demarco, R, Dickinson, ME, Galaz, G, Grazian, A, Holwerda, BW, Jarvis, MJ, Kasliwal, V, Lacerna, I, Loveday, J, Marshall, P, Merlin, E, Napolitano, NR, Puzia, TH, Robotham, A, Salim, S, Sereno, M, Snyder, GF, Stott, JP, Tissera, PB, Werner, N, Yoachim, P, Borne, KD, LSST Galaxies Science Collaboration

“…The Galaxies Science Roadmap will serve as a guiding document for researchers interested in conducting extragalactic science in anticipation of the forthcoming LSST era.…”

Dual-resolution correspondence networks by Li, X, Li, S, Han, K, Prisacariu, VA

“…The fine-resolution feature maps are used to obtain the final dense correspondences guided by the refined coarse 4D correlation tensor. …”

Structural premise of selective deubiquitinase USP30 inhibition by small-molecule benzosulfonamides by O'Brien, DP, Jones, HBL, Guenther, F, Murphy, EJ, England, KS, Anderson, M, Brennan, P, Davis, JB, Pinto-Fernandez, A, Turnbull, AP, Kessler, BM

“…These studies suggest that 39 binds to the thumb-palm cleft that guides the ubiquitin C-terminus into the active site, thereby preventing ubiquitin binding and isopeptide bond cleavage, and confirming its importance in the inhibitory process. …”

Digital health technologies and machine learning augment patient reported outcomes to remotely characterise rheumatoid arthritis by Creagh, AP, Hamy, V, Yuan, H, Mertes, G, Tomlinson, R, Chen, W-H, Williams, R, Llop, C, Yee, C, Duh, MS, Doherty, A, Garcia-Gancedo, L, Clifton, DA

“…Sensor-based measures of health status, mobility, dexterity, fatigue, and other RA specific symptoms were extracted from daily iPhone guided tests (GT), as well as actigraphy and heart rate sensor data, which was passively recorded from patients’ Apple smartwatch continuously over the study duration. …”