Microglial colonisation of the developing brain is facilitated by clonal expansion of highly proliferative progenitors and follows an allometric scaling by Barry-Carroll, L, Greulich, P, Marshall, AR, Riecken, K, Fehse, B, Askew, KE, Li, K, Garaschuk, O, Menassa, DA, Gomez-Nicola, D

“…Moreover, the developmental increase in microglia follows the proportional growth of the brain in an allometric manner with the density of microglia eventually stabilising when the mosaic distribution has been established. Overall, our findings offer insight into how the competition for space acts as a driving force for microglial colonisation by clonal expansion during development.…”