Dance Sport Movement Therapy in the Metaverse: a new frontier for alternative mental health therapies by Radanliev, P

“…The study employed a blend of qualitative evidence synthesis and meta-analyses of primary quantitative data, focusing on the therapeutic implications of dance in virtual, augmented, and mixed realities. …”

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease by Fowler, SL, Behr, TS, Turkes, E, Cauhy, PM, Foiani, MS, Schaler, A, Crowley, G, Bez, S, Ficulle, E, Tsefou, E, O'Brien, DP, Fischer, R, Geary, B, Gaur, P, Miller, C, D'Acunzo, P, Levy, E, Duff, KE, Ryskeldi-Falcon, B

“…Our findings will guide studies into the molecular mechanisms of EV-mediated secretion of assembled tau and inform the targeting of EV-associated tau as potential therapeutic and biomarker strategies for AD.…”

Structural premise of selective deubiquitinase USP30 inhibition by small-molecule benzosulfonamides by O'Brien, DP, Jones, HBL, Guenther, F, Murphy, EJ, England, KS, Anderson, M, Brennan, P, Davis, JB, Pinto-Fernandez, A, Turnbull, AP, Kessler, BM

“…Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. …”

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A by Brierley, CK, Yip, BH, Orlando, G, Goyal, H, Wen, S, Wen, J, Levine, MF, Jakobsdottir, GM, Rodriguez-Meira, A, Adamo, A, Bashton, M, Hamblin, A, Clark, SA, O'Sullivan, J, Murphy, L, Olijnik, AA, Cotton, A, Narina, S, Pruett-Miller, SM, Enshaei, A, Harrison, C, Drummond, M, Knapper, S, Tefferi, A, Antony-Debré, I, Thongjuea, S, Wedge, DC, Constantinescu, S, Papaemmanuil, E, Psaila, B, Crispino, JD, Mead, AJ

“…Whether chromothripsis might constitute an actionable molecular event amenable to therapeutic targeting remains an open question. We describe recurrent chromothripsis of chromosome 21 in a subset of patients in blast phase of a myeloproliferative neoplasm (BP-MPN), which alongside other structural variants leads to amplification of a region of chromosome 21 in ∼25% of patients (‘chr21amp’). …”

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease by Yang, X, Artibani, M, Jin, Y, Aggarwal, A, Zhang, Y, Munoz-Galvan, S, Mikhailova, E, Rai, L, Mukherjee, N, Krishna Kumar, R, Albukhari, A, Zhou, L, Ahmed, AA, Bayley, H

“…<p><strong>Background</strong> Bulk cancer and minimal residual disease (MRD) are characterised by different molecular drivers and therefore necessitate different therapeutic strategies. However, there are currently no 3D models that can faithfully recapitulate MRD ex vivo for therapy development.…”

Acute to long-term characteristics of impedance recordings during neurostimulation in humans by Cui, J, Mivalt, F, Sladky, V, Kim, J, Richner, TJ, Lundstrom, BN, Van Gompel, JJ, Wang, H-L, Miller, KJ, Gregg, N, Wu, LJ, Denison, T, Winter, B, Brinkmann, BH, Kremen, V, Worrell, GA

“…These insights may offer additional guidance for the delivery of therapeutic stimulation at various time points post-implantation for neuromodulation therapy.…”