Mesoscopic dynamic model of epithelial cell division with cell-cell junction effects by Liu, Zong-Yuan, Li, Bo, Zhao, Zi-Long, Xu, Guang-Kui, Feng, Xi-Qiao, Gao, Huajian

Subjects: Get full text

PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells by Groh, Ann-Christin, Möller-Kerutt, Annika, Gilhaus, Kevin, Höffken, Verena, Nedvetsky, Pavel, Kleimann, Simon, Behrens, Malina, Ghosh, Sujasha, Hansen, Uwe, Krahn, Michael P., Ebnet, Klaus, Pavenstädt, Hermann, Ludwig, Alexander, Weide, Thomas

Subjects: Get full text

Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms by Yap, Karen, Xiao, Yixin, Friedman, Brad A., Je, H. Shawn, Makeyev, Eugene V.

“…In an important example of this scenario, cell polarity gene Cdc42, a combination of polypyrimidine tract-binding, protein-dependent, and constitutive splicing mechanisms ensures a halfway switch from the general (E7) to the neuron-specific (E6) alternative 30-terminal exon during neuronal differentiation. …”
Get full text
Get full text

Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast by Miao, Yansong, Han, Xuemei, Zheng, Liangzhen, Xie, Ying, Mu, Yuguang, Yates, John R., Drubin, David G.

“…Actin cables, composed of actin filament bundles nucleated by formins, mediate intracellular transport for cell polarity establishment and maintenance. We previously observed that metaphase cells preferentially promote actin cable assembly through cyclin-dependent kinase 1 (Cdk1) activity. …”
Get full text
Get full text

The mammalian crumbs complex defines a distinct polarity domain apical of epithelial tight junctions by Tan, Benedict, Siti Maryam J. M. Yatim, Peng, Suat, Gunaratne, Jayantha, Hunziker, Walter, Ludwig, Alexander

“…Taken together, our work defines the spatial and molecular organization of the apical-lateral border in mammalian epithelial cells, reveals an intriguing molecular and spatial conservation of invertebrate and vertebrate cell polarity protein domains, and identifies a VMZ-associated protein network implicated in HIPPO signaling and the control of the cortical actin cytoskeleton.…”
Get full text

Spatiotemporal oscillation in confined epithelial motion upon fluid-to-solid transition by Yu, Jing, Cai, Pingqiang, Zhang, Xiaoqian, Zhao, Tiankai, Liang, Linlin, Zhang, Sulin, Liu, Hong, Chen, Xiaodong

“…The oscillation pattern and cellular nanomechanics profile appear well correlated with stress fiber assembly and cell polarization. These experimental observations imply that the confinement size-dependent surface tension regulates actin fiber assembly, cellular force generation, and cell polarization. …”
Get full text

Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelialization by Hu, Benhui, Leow, Wan Ru, Amini, Shahrouz, Nai, Brenda, Zhang, Xiaoqian, Liu, Zhiyuan, Cai, Pingqiang, Li, Zhuyun, Wu, Yun-Long, Miserez, Ali, Lim, Chwee Teck, Chen, Xiaodong

“…Here, it is reported that the spatial organization of adjacent adherent paths within sparsely distributed extracellular matrix (ECM) has a significant impact on the orientational coupling between cell polarization and collective cell migration. This coupling effect determines the migration pattern for human keratinocytes to regain their cohesion, which impacts the occupancy of epithelial bridge and the migration velocity in wound repair. …”
Get full text
Get full text

X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis by Jain, Neeraj, Tan, Jun Hou, Feng, Shijin, George, Bhawana, Thanabalu, Thirumaran

“…In addition JurkatWASP-KD T cells expressing these two WASP mutants were found to be defective in T cell polarization when stimulated with SDF-1α. WASP exists in a closed conformation in the presence of WIP, however both the mutants (WASPRL46P and WASPRA47D) were found to be in an open conformation as determined in the bi-molecular complementation assay. …”
Get full text
Get full text