Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis by Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-San, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok

“…Taken together, our findings unravel mechanistic insights into MDSC-mediated immunosuppression and offer a therapeutic kinase-target for cancer immunotherapy.…”
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An adjuvant micelle-based multifunctional nanosystem for tumor immunotherapy by remodeling three types of immunosuppressive cells by Meng, Siyu, Du, Huiping, Li, Xiang, Zheng, Xinmin, Zhao, Pan, Yuan, Zhang, Huang, Shaohui, Zhao, Yanli, Dai, Liangliang

“…Immunotherapy is restricted by a complex tumor immunosuppressive microenvironment (TIM) and low drug delivery efficiency. …”
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The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38) by Kang, Cong Bao, Tai, Jeff, Chia, Joel, Yoon, Ho Sup

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PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma by Liu, Xiaoyu, Liu, Man, Wu, Haoran, Tang, Wenshu, Yang, Weiqin, Chan, Thomas T. H., Zhang, Lingyun, Chen, Shufen, Xiong, Zhewen, Liang, Jianxin, Si-Tou, Willis Wai-Yiu, Shu, Ting, Li, Jingqing, Cao, Jianquan, Zhong, Chengpeng, Sun, Hanyong, Kwong, Tsz Tung, Leung, Howard H. W., Wong, John, Lai, Paul Bo-San, To, Ka-Fai, Xiang, Tingxiu, Sung, Joseph Jao Yiu, Chan, Stephen Lam, Zhou, Jingying, Cheng, Alfred Sze-Lok

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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver by Gan, Wei Liang, Ren, Xi, Ng, Vanessa Hui En, Ng, Larry, Song, Yangyang, Tano, Vincent, Han, Jian, An, Omer, Xie, Jinghe, Ng, Bryan Y. L., Tay, Daryl Jin Tai, Tang, Sze Jing, Shen, Haoqing, Khare, Shruti, Chong, Kelvin Han Chung, Young, Dan Yock, Wu, Bin, DasGupta, Ramanuj, Chen, Leilei

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Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study by Tang, Raymond S. Y., Sattayalertyanyong, Onuma, Kuo, Yu-Ting, Park, Kenneth H., Anastassiades, Constantinos, Ligresti, Dario, Hayashi, Nobuhiko, Hasan, Aws, Kim, Tae-Hyeon, Pausawasdi, Nonthalee, Wang, Hsiu-Po, Lo, Simon K., Ho, Khek-Yu, Barresi, Luca, Traina, Mario, Yasuda, Ichiro, Savides, Thomas J., Koo, Chieh-Sian, Chan, Ting Ting, Lam, Thomas Y. T., Sung, Joseph Jao Yiu

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Targeted immunotherapy for hair regrowth and regeneration by Toh, En Qi, Wang, Etienne C. E.

“…While the main strategy for treating inflammatory conditions is local or systemic immunosuppression, immunotherapy aims to stimulate parts or all of the immune system to bring about a therapeutic response. …”
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Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies? by Verma, Navin K., Kelleher, Dermot

“…Specific blockade of these interactions has validated LFA-1 as a therapeutic target in many chronic inflammatory diseases, however LFA-1 antagonists have not been clinically successful due to the development of a general immunosuppression, causing fatal side effects. Growing evidence has now established that LFA-1 mediates an array of intracellular signaling pathways by triggering a number of downstream molecules. …”
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Isolated gallbladder tuberculosis mimicking acute cholecystitis : a case report by Chan, Kai Siang, Shelat, Vishal G., Tan, Cher Heng, Tang, Yee Lin, Junnarkar, Sameer P.

“…Gallbladder tuberculosis is a rare entity but should be suspected in patients from endemic regions with risk factors such as underlying immunosuppression or history of tuberculosis. Case Summary: We present a case of gallbladder tuberculosis presenting as acute cholecystitis. …”
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Isolated anterior mediastinal tuberculosis in an immunocompetent patient by Maguire, S., Chotirmall, Sanjay Haresh, Parihar, V., Cormican, L., Ryan, C., O’Keane, C, Redmond, K., Smyth, C.

“…Cases similar to this have been documented in immunosuppressed patients however in our case no evidence of immunosuppression was found. …”
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Recent progresses in phototherapy-synergized cancer immunotherapy by Li, Jingchao, Pu, Kanyi, Ng, Chee Wee

“…Future advancements targeting different cancer checkpoints that could offer better immunosuppression coupled with other phototherapeutic strategies remains to be explored in accomplishing complete elimination of cancer.…”
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Current status of stem cell-derived therapies for Parkinson’s disease : from cell assessment and imaging modalities to clinical trials by Jang, Se Eun, Qiu, Lifeng, Chan, Ling Ling, Tan, Eng-King, Zeng, Li

“…Modifying factors include (1) source of the stem cells, (2) quality of the stem cells, (3) age of the patient, (4) stage of disease progression at the time of cell therapy, (5) surgical technique/practices, and (6) the use of immunosuppression. We await the outcomes of joint efforts in clinical trials around the world such as NYSTEM and CiRA to further guide us in the selection of the most suitable parameters for cell-based neurotransplantation in PD.…”
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Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift by Park, Jung Eun, Dutta, Bamaprasad, Tse, Shun Wilford, Gupta, Nikhil, Tan, Chee Fan, Low, Jee Keem, Yeoh, Kheng Wei, Kon, Oi Lian, Tam, James P., Sze, Siu Kwan

“…Developing tumors rapidly outgrow their oxygen supply and are subject to hypoxia, which stimulates hypersecretion of tumor-derived exosomes that promote angiogenesis, metastasis, and immunosuppression, but the molecular mediators of these pathological effects remain poorly defined. …”
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Heterostructural nanoadjuvant CuSe/CoSe₂ for potentiating ferroptosis and photoimmunotherapy through intratumoral blocked lactate efflux by Yang, Chunzheng, Wang, Man, Chang, Mengyu, Yuan, Meng, Zhang, Wenying, Tan, Jia, Ding, Binbin, Ma, Ping'an, Lin, Jun

“…The desirable curative effect in clinical immunotherapy has been challenging due to the immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism in solid tumors. …”
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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications by Wu, Xianbo, Li, Yuqing, Wen, Mei, Xie, Yongting, Zeng, Ke, Liu, You-Nian, Chen, Wansong, Zhao, Yanli

“…Immunotherapy harnesses the inherent immune system in the body to generate systemic antitumor immunity, offering a promising modality for defending against cancer. However, tumor immunosuppression and evasion seriously restrict the immune response rates in clinical settings. …”
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LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway by Ong, Seow Theng, Low, Jian Hui, Kottaiswamy, Amuthavalli, Kizhakeyil, Atish, Kumar, Sunil, Panda, Aditya K., Freeley, Michael, Smith, Sinead M., Boehm, Bernhard O., Kelleher, Dermot, Verma, Navin Kumar, Mobashar Hussain Urf Turabe Fazil, Chalasani, Madhavi Latha Somaraju, Praseetha P

“…Although clinical use of LFA-1 antagonists is limited by toxicity related to immunosuppression, these findings support the concept that Notch inhibitors could be attractive for prevention or treatment of Th1-related immunologic disorders and have implications at the level of local inflammatory responses.…”
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Impact of tacrolimus versus cyclosporine on one-year renal transplant outcomes : a single-centre retrospective cohort study by Ong, Pei Wen, Kee, Terence, Ho, Quan Yao

“…Background: Calcineurin inhibitors are the cornerstone of maintenance immunosuppression after kidney transplant. While studies on predominantly Caucasian populations recommend tacrolimus over cyclosporine, the effects on Singapore’s local population remain unclear. …”
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Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair by Shen, Weiliang, Chen, Jialin, Yin, Zi, Chen, Xiao, Liu, Huan Huan, Heng, Boon Chin, Chen, Weishan, Ouyang, Hong-Wei

“…TSPCs, which exhibited universal stem cell characteristics (i.e., clonogenicity, high proliferative capacity, and multidifferentiation potential), nonimmunogenicity, and immunosuppression, proliferated well on our scaffold in vitro. …”
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Microenvironmental hypoxia induces dynamic changes in lung cancer synthesis and secretion of extracellular vesicles by Tse, Shun Wilford, Tan, Chee Fan, Park, Jung Eun, Gnanasekaran, JebaMercy, Gupta, Nikhil, Low, Jee Keem, Yeoh, Kheng Wei, Chng, Wee Joo, Tay, Chor Yong, McCarthy, Neil E., Lim, Sai Kiang, Sze, Siu Kwan

“…Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that hypoxic tumours synthesize hypoxia-sensitive proteins for packing into EVs to modulate their microenvironment for cancer progression. …”
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Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic r... by Park, Jung Eun, Tse, Shun Wilford, Xue, Guo, Assisi, Christina, Maqueda, Aida Serra, Ramon, Gallart Palau Xavier, Low, Jee Keem, Kon, Oi Lian, Tay, Chor Yong, Tam, James P., Sze, Siu Kwan

“…Hypoxia is an environmental cue that is associated with multiple tumorigenic processes such as immunosuppression, angiogenesis, cancer invasion, metastasis, drug resistance, and poor clinical outcomes. …”
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