Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration by Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.

“…Beyond APOE, we show that in living subjects, polygenic hazard scores were associated with amyloid deposition and neurodegeneration in susceptible brain regions. Polygenic hazard scores may also be useful for the identification of individuals at the highest risk for developing multi-aetiological dementia.…”
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Neurofilament light as a blood biomarker for neurodegeneration in down syndrome by Strydom, Andre, Heslegrave, Amanda, Startin, Carla M., Mok, Kin Y., Hardy, John, Groet, Jurgen, Nizetic, Dean, Zetterberg, Henrik

“…Conclusions NF-L is a biomarker for neurodegeneration in DS with potential for use in future clinical trials to prevent or delay dementia.…”
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MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey

“…The resulting neurodegeneration can be suppressed by overexpressing a glycolytic enzyme or treatment with deferoxamine, suggesting that compensatory glycolysis is neuroprotective. …”
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Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia by Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran

“…We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. …”
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Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling by Adav, Sunil Shankar, Sze, Siu Kwan

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Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition by Tan, Chin Hong, Tan, Jacinth J. X.

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The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis by Zhou, Zhi Dong, Saw, Wuan Ting, Ho, Patrick Ghim Hoe, Zhang, Zhi Wei, Zeng, Li, Chang, Ya Yin, Sun, Alfred Xu Yang, Ma, Dong Rui, Wang, Hong Yan, Zhou, Lei, Lim, Kah-Leong, Tan, Eng-King

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Brief report : isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration by Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan-Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna-Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean

“…DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ageing, neurodegeneration, dementia, cancer, and other important common diseases. …”
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Mitochondrial regulation of microglial immunometabolism in Alzheimer’s disease by Fairley, Lauren H., Wong, Jia Hui, Barron, Anna M.

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High diagnostic utility incorporating a targeted neurodegeneration gene panel with MRI brain diagnostic algorithms in patients with young-onset cognitive impairment with leukodystrophy by Chen, Zhiyong, Tan, Yi Jayne, Lian, Michelle Mulan, Tandiono, Moses, Foo, Jia Nee, Lim, Weng Khong, Kandiah, Nagaendran, Tan, Eng-King, Ng, Adeline S. L.

“…We performed sequencing using a custom-designed panel of 200 neurodegeneration-associated genes on 45 patients with young-onset cognitive impairment with leukodystrophy, and classified them based on van der Knaap et al.'…”
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Liver's influence on the brain through the action of bile acids by Yeo, Xin Yi, Tan, Li Yang, Chae, Woo Ri, Lee, Dong-Yup, Lee, Yong-An, Wuestefeld, Torsten, Jung, Sangyong

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Longitudinal analysis of retinal microvascular and choroidal imaging parameters in Parkinson's disease compared with controls by Kundu, Anita, Ma, Justin P., Robbins, Cason B., Pant, Praruj, Gunasan, Vithiya, Agrawal, Rupesh, Stinnett, Sandra, Scott, Burton L., Moore, Kathryn P. L., Fekrat, Sharon, Grewal, Dilraj S.

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Uncovering Neurodegenerative Protein Modifications via Proteomic Profiling by Gallart-Palau, Xavier, Serra, Aida, Sze, Siu Kwan

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Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases by Lo, Chih Hung, Zeng, Jialiu

“…Similar lysosomal abnormalities are also present in sporadic forms of neurodegeneration, although the underlying pathogenic mechanisms are unclear and remain to be investigated. …”
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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly by Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako

“…Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. …”
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Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition by Kan, Cheuk Ni, Xu, Xin, Schmetterer, Leopold, Venketasubramanian, Narayanaswamy, Chen, Christopher, Tan, Chin Hong

“…Lower composite MRI scores corresponding to greater comorbid neurodegeneration and CeVD burden were associated with hyperactivity (OR = 1.48) and apathy (OR = 1.90) subsyndromes. …”
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Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice by Zhou, Libin, Flores, Joseph, Noël, Anastasia, Beauchet, Olivier, Sjöström, P. Jesper, LeBlanc, Andrea C.

“…Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits, neurodegeneration and neuroinflammation. This study assessed if methylene blue (MB), a phenothiazine that inhibits caspases, alters Caspase-6-induced neurodegeneration and cognitive impairment in mice. …”
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Spinal cord organoids add an extra dimension to traditional motor neuron cultures by Winanto, Khong, Zi-Jian, Hor, Jin-Hui, Ng, Shi-Yan

“…Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. …”
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Brain site-specific proteome changes in aging-related dementia by Manavalan, Arulmani, Mishra, Manisha, Feng, Lin, Sze, Siu Kwan, Akatsu, Hiroyasu, Heese, Klaus

“…Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain site-specific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. …”
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MRI Markers of Mixed Pathology and Cognitive Impairment in Multiethnic Asians by Tan, Chin Hong, Hilal, Saima, Xu, Xin, Vrooman, Henri, Cheng, Ching-Yu, Wong, Tien Yin, Venketasubramanian, Narayanaswamy, Chen, Christopher

“…There is a need to elucidate the combined influence of neurodegeneration and cerebrovascular disease (CeVD) on cognitive impairment, especially in diverse populations. …”
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