Evaluation of an artificial pancreas in in silico patients with online-tuned internal model control by Cho, Namjoon, Bhattacharjee, Arpita, Easwaran, Arvind, Leow, Melvin Khee-Shing

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Design of an online-tuned model based compound controller for a fully automated artificial pancreas by Bhattacharjee, Arpita, Easwaran, Arvind, Leow, Melvin Khee-Shing, Cho, Nam-Joon

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Turnover kinetics of pancreatic macrophages in lean and obese diabetic mice by Ma, Ziyuan, Ruedl, Christiane

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GATA6 cooperates with EOMES/SMAD2/3 to deploy the gene regulatory network governing human definitive endoderm and pancreas formation by Chia, Crystal Y., Madrigal, Pedro, Denil, Simon L.I.J., Martinez, Iker, Garcia-Bernardo, Jose, El-Khairi, Ranna, Chhatriwala, Mariya, Shepherd, Maggie H., Hattersley, Andrew T., Vallier, Ludovic, Dunn, Norris Ray

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HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells by Joanita Jasmen, Ng, Natasha Hui Jin, Lim, Chang Siang, Lau, Hwee Hui, Krishnan, Vidhya Gomathi, Kadiwala, Juned, Kulkarni, Rohit N., Ræder, Helge, Vallier, Ludovic, Hoon, Shawn, Teo, Adrian Kee Keong

“…Our results suggest that in MODY1, liver and pancreas development is perturbed early on, contributing to altered hepatic proteins and β cell defects in patients.…”
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Knowledge gaps in rodent pancreas biology : taking human pluripotent stem cell-derived pancreatic beta cells into our own hands by Santosa, Munirah Mohamad, Low, Blaise Su Jun, Pek, Nicole Min Qian, Teo, Adrian Kee Keong

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In vivo visualization of β-cells by targeting of GPR44 by Eriksson, Olof, Johnström, Peter, Cselenyi, Zsolt, Jahan, Mahabuba, Selvaraju, Ram K., Jensen-Waern, Marianne, Takano, Akihiro, Winzell, Maria Sörhede, Halldin, Christer, Skrtic, Stanko, Korsgren, Olle

“…GPR44 expression has recently been described as highly β-cell selective in the human pancreas and constitutes a tentative surrogate imaging biomarker in diabetes. …”
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The molecular functions of hepatocyte nuclear factors - in and beyond the liver by Lau, Hwee Hui, Ng, Natasha Hui Jin, Loo, Larry Sai Weng, Joanita Jasmen, Teo, Adrian Kee Keong

“…The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas and kidney. The spatial and temporal manner of HNF expression regulates embryonic development and subsequently the development of multiple tissues during adulthood. …”
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Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue injury in severe acute pancreatitis by Merza, Mohammed, Rahman, Milladur, Zhang, Songen, Hwaiz, Rundk, Regner, Sara, Schmidtchen, Artur, Thorlacius, Henrik

“…TDPs reduced blood amylase levels, neutrophil infiltration, hemorrhage, necrosis, and edema formation in the inflamed pancreas. Treatment with TDPs markedly attenuated the taurocholate-induced increase in plasma levels of CXCL2 and interleukin-6. …”
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A roadmap for human liver differentiation from pluripotent stem cells by Ang, Lay Teng, Tan, Antson Kiat Yee, Autio, Matias I., Goh, Su Hua, Choo, Siew Hua, Lee, Kian Leong, Tan, Jianmin, Pan, Bangfen, Lee, Jane Jia Hui, Lum, Jen Jen, Lim, Christina Ying Yan, Yeo, Isabelle Kai Xin, Wong, Chloe Jin Yee, Liu, Min, Oh, Jueween Ling Li, Chia, Cheryl Pei Lynn, Loh, Chet Hong, Chen, Angela, Chen, Qingfeng, Weissman, Irving L., Loh, Kyle M., Lim, Bing

“…How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? …”
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The eye as a transplantation site to monitor pancreatic islet cell plasticity by Ilegems, Erwin, Berggren, Per-Olof

“…In this respect a number of imaging methodologies have been developed over the years for the study of islets in situ in the pancreas, a challenging task due to the relatively small size of the islets and their location, scattered throughout the organ. …”
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Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes by van Krieken, Pim P., Dicker, Andrea, Eriksson, Maria, Herrera, Pedro L., Ahlgren, Ulf, Berggren, Per-Olof, Ilegems, Erwin

“…Our results illustrate the importance of acquiring quantitative functional and morphological parameters to assess the functional status of the endocrine pancreas.…”
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Algorithms for the automated detection of diabetic retinopathy using digital fundus images : a review by Faust, Oliver, Acharya, U. Rajendra, Ng, Eddie Yin-Kwee, Ng, Kwan-Hoong, Suri, Jasjit S.

“…Diabetes is a chronic end organ disease that occurs when the pancreas does not secrete enough insulin or the body is unable to process it properly. …”
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Pancreatic Islet Blood Flow Dynamics in Primates by Diez, Juan Antonio, e Drigo, Rafael Arrojo, Zheng, Xiaofeng, Stelmashenko, Olga Victoria, Chua, Minni, Rodriguez-Diaz, Rayner, Fukuda, Masahiro, Köhler, Martin, Leibiger, Ingo, Tun, Sai Bo Bo, Ali, Yusuf, Augustine, George James, Barathi, Veluchamy A., Berggren, Per-Olof

“…Engrafted islets were vascularized and innervated and maintained the cytoarchitecture of in situ islets in the pancreas. Blood flow velocity in the engrafted islets was not affected by increasing blood glucose levels and/or the GLP-1R agonist liraglutide. …”
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Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells by Trott, Jamie, Tan, Ee Kim, Ong, Sheena, Titmarsh, Drew M., Denil, Simon L.I.J., Giam, Maybelline, Wong, Cheng Kit, Wang, Jiaxu, Shboul, Mohammad, Eio, Michelle, Cooper-White, Justin, Cool, Simon M., Rancati, Giulia, Stanton, Lawrence W., Reversade, Bruno, Dunn, Norris Ray

“…We have developed culture conditions that support long-term self-renewal of human multipotent pancreatic progenitors, which are developmentally more proximal to the specialized cells of the adult pancreas. These cultured pancreatic progenitor (cPP) cells express key pancreatic transcription factors, including PDX1 and SOX9, and exhibit transcriptomes closely related to their in vivo counterparts. …”
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Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation by Acharya, U. Rajendra, Ghista, Dhanjoo N., Nergui, Myagmarbayar, Chattopadhyay, Subhagata, Ng, Eddie Yin-Kwee, Sree, Subbhuraam Vinitha, Tong, Jasper W. K., Tan, Jen Hong, Meng, Loh Kah, Suri, Jasjit S.

“…The glucose balance is maintained by a hormone called insulin that is secreted by the beta cells of pancreas. Hypotheses at the backdrop of DM occurrence are either (i) enough insulin is not produced and secreted resulting in increased level of glucose in blood, or (ii) insulin is insensitive to glucose, or (iii) insulin is non-targeted etc. …”
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Gut-muscle crosstalk. a perspective on influence of microbes on muscle function by Chew, Weixuan, Lim, Yen Peng, Lim, Wee Shiong, Chambers, Edward S., Frost, Gary, Wong, Sunny Hei, Ali, Yusuf

“…Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the function of important metabolic organs, from the adipose tissues to the endocrine pancreas to the skeletal muscle. Muscle, as the biggest utilizer of ingested glucose and an important reservoir of body proteins, is intricately linked with homeostasis, and with important anabolic and catabolic functions, respectively. …”
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Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice by Firth, George, Georgiadou, Eleni, Griffiths, Alexander, Amrahli, Maral, Kim, Jana, Yu, Zilin, Hu, Ming, Stewart, Theodora J., Leclerc, Isabelle, Okamoto, Haruka, Gomez, Daniel, Blower, Philip J., Rutter, Guy A.

“…Here, we aimed to determine how one or two copies of the mutant R138X allele in the mouse SLC30A8 gene impacts the homeostasis of zinc at a whole-body (using non-invasive 62Zn PET imaging to assess the acute dynamics of zinc handling) and tissue/cell level [using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to map the long-term distribution of zinc and manganese in the pancreas].…”
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Occam's razor or Hickam's dictum-COVID-19 is not a textbook aetiology of acute pancreatitis: a modified Naranjo score appraisal by Teng, Thomas Zheng Jie, Chua, Branden Qi Yu, Lim, Puay Khim, Chan, Kai Siang, Shelat, Vishal G.

“…Only 5 (6.6%) patients underwent endoscopic ultrasound and/or magnetic resonance cholangiopancreatogram to rule out occult microlithiasis, pancreatic malignancy and pancreas divisum. None of the patients had other recently diagnosed viral infections apart from COVID-19 infection, or underwent genetic testing to rule out hereditary AP. …”
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