Increased resting bronchial tone in normal subjects acclimatised to altitude. by Wilson, C, Bakewell, SE, Miller, MR, Hart, N, McMorrow, R, Barry, P, Collier, D, Watt, S, Pollard, A

“…Bronchial hyperresponsiveness (BHR) and full and partial flow-volume loops were measured before and after ascent to 5000 m altitude to determine if there are changes in resting bronchial tone and BHR that might explain the symptoms. …”

Weight loss at high altitude: pathophysiology and practical implications. by Hamad, N, Travis, S

“…Climbers at high altitude (>5000 m) lose weight. This impairs performance and safety, but the mechanisms are not entirely due to an imbalance between energy intake and expenditure. …”

Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide tr... by Basnyat, B, Holck, P, Pun, M, Halverson, S, Szawarski, P, Gertsch, J, Steif, M, Powell, S, Khanal, S, Joshi, A, Shankar, R, Karambay, J, Alexander, H, Stone, A, Morrissey, C, Thompson, B, Farrar, J

“…CONCLUSIONS: Spironolactone (50 mg BID) was ineffective in comparison to acetazolamide (250 mg BID) in the prevention of AMS in partially acclimatized western trekkers ascending to 5000 m in the Nepali Himalaya.…”

The rhenium isotope composition of Atlantic Ocean seawater by Dickson, AJ, Hsieh, Y-T, Bryan, A

“…Salinity-normalized Re concentrations in both locations range between ∼6.8–7.7 ppt between 50–5000 m depth, consistent with previously published concentration data from the North Atlantic and North Pacific Oceans. …”

Random movement of mesoscale eddies in the global ocean by Ni, Q, Zhai, X, Wang, G, Marshall, DP

“…The zonal-mean eddy energy diffusivity varies from over 1500 m2 s−1 at low latitudes to around 500 m2 s−1 at high latitudes, but significantly larger values are found in the eddy energy hotspots at all latitudes, in excess of 5000 m2 s−1. Results from this study have important implications for recently developed energetically consistent mesoscale eddy parameterization schemes which require solving the eddy energy budget.…”

Extreme submillimetre starburst galaxies by Rowan-Robinson, M, Wang, L, Farrah, D, Rigopoulou, D, Gruppioni, C, Vaccari, M, Marchetti, L, Clements, D

“…Both surveys demonstrate the existence of “extreme” starbursts, with star-formation rates (SFRs) > 5000 M⊙ yr−1. The maximum intrinsic star-formation rate appears to be ~30 000 M⊙ yr−1. …”

Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study. by Nickol, A, Leverment, J, Richards, P, Seal, P, Harris, G, Cleland, J, Dubowitz, G, Collier, D, Milledge, J, Stradling, JR, Morrell, M

“…Volunteers took 10 mg of temazepam and placebo in random order on two successive nights soon after arrival at 5000 m, following a 17-day trek from 410 m. Overnight SaO(2) and body movements, and next-day reaction time, maintenance of wakefulness and cognition were assessed. …”

Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans. by Basnyat, B, Hargrove, J, Holck, P, Srivastav, S, Alekh, K, Ghimire, L, Pandey, K, Griffiths, A, Shankar, R, Kaul, K, Paudyal, A, Stasiuk, D, Basnyat, R, Davis, C, Southard, A, Robinson, C, Shandley, T, Johnson, D, Zafren, K, Williams, S, Weiss, E, Farrar, J, Swenson, E

“…In this randomized, double-blind placebo controlled trial our objectives were to determine if acetazolamide is capable of preventing high altitude pulmonary edema (HAPE) in trekkers traveling between 4250 m (Pheriche)\4350 m (Dingboche) and 5000 m (Lobuje) in Nepal; to determine if acetazolamide decreases pulmonary artery systolic pressures (PASP) at high altitude; and to determine if there is an association with PASP and signs and symptoms of HAPE. …”

Age of crustal melting, emplacement and exhumation history of the Shivling leucogranite, Garhwal Himalaya by Searle, M, Noble, SR, Hurford, A, Rex, D

“…K-Ar muscovite ages are 22 ± 1.0 Ma and fission track ages of zircons from >5000 m on the North Ridge of Shivling are 14.2 ± 2.1 and 8.8 ± 1.2 Ma and apatites are 3.5 ± 0.79 and 2.61 ± 0.23 Ma. …”

Structurally stable Mg-doped P2-Na2/3Mn1-yMgyO2 sodium-ion battery cathodes with high rate performance: Insights from electrochemical, NMR and diffraction studies by Clément, R, Billaud, J, Armstrong, A, Singh, G, Rojo, T, Bruce, P, Grey, C

“…The 5% Mgdoped phase exhibits one of the best rate performances reported to date for sodium-ion cathodes with a P2 structure, with a reversible capacity of 106 mAhg-1 at the very high discharge rate of 5000 mAg-1. In addition, its structure is highly reversible and stable cycling is obtained between 1.5 and 4.0 V vs. …”

Identifying and quantifying natural CO2 sequestration processes over geological timescales: The Jackson Dome CO2 Deposit, USA by Zhou, Z, Ballentine, C, Schoell, M, Stevens, S

“…Located in central Mississippi, USA, and producing from >5000m, it is one of the deepest commercial CO 2 gas fields in the world. 10 gas samples from producing wells were determined for their noble gas, chemical and stable carbon isotope composition. 3He/ 4He ratios range between 4.27R a and 5.01R a (where R a is the atmospheric value of 1.4×10 -6), indicating a strong mantle signature. …”

Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection by Mukaka, M, Peerawaranun, P, Parker, DM, Kajeechiwa, L, Nosten, FH, Nguyen, T-N, Hien, TT, Tripura, R, Peto, TJ, Phommasone, K, Mayxay, M, Newton, PN, Imwong, M, Day, NPJ, Dondorp, AM, White, NJ, von Seidlein, L

“…The parasite density thresholds for rapid diagnostic test (RDT) detection was assumed to be > 50/µL (50,000/mL), for dried-blood-spot (DBS) based PCR > 5/µL (5000/mL), and for ultrasensitive PCR (uPCR) with a validated limit of detection at 0.0022/µL (22/mL). …”